YKR007W / MEH1

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR007W / MEH1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.39|P-value:6.62E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.41|P-value:8.77E-16 ID:SGTC_56|Compound:0957-0365|FD-Score:12.40|P-value:7.02E-32 ID:SGTC_58|Compound:0957-0393|FD-Score:6.91|P-value:3.06E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:4.81|P-value:2.69E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.59|P-value:3.43E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.07|P-value:5.85E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.65|P-value:4.56E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.10|P-value:7.05E-7 ID:SGTC_228|Compound:caffeine|FD-Score:4.86|P-value:2.13E-6 ID:SGTC_251|Compound:melphalan|FD-Score:4.02|P-value:7.07E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.22|P-value:3.33E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.74|P-value:3.67E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.76|P-value:2.56E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.50|P-value:6.64E-13 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.75|P-value:1.97E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.68|P-value:4.82E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:3.54|P-value:4.06E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.60|P-value:6.90E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:3.90|P-value:1.12E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.35|P-value:7.63E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.62|P-value:3.13E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.52|P-value:4.29E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:9.49|P-value:1.41E-19 ID:SGTC_976|Compound:1348-1067|FD-Score:3.35|P-value:7.79E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.29|P-value:9.16E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.80|P-value:1.65E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.32|P-value:8.35E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.48|P-value:5.00E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.72|P-value:2.19E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.83|P-value:1.43E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.51|P-value:4.43E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.07|P-value:5.89E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.82|P-value:1.84E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:17.40|P-value:7.52E-61 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.68|P-value:1.81E-13 ID:SGTC_1917|Compound:st066507|FD-Score:4.67|P-value:5.05E-6 ID:SGTC_2026|Compound:5148700|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_2177|Compound:5811945|FD-Score:11.50|P-value:8.38E-28 ID:SGTC_2186|Compound:6124449|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_2264|Compound:7948757|FD-Score:5.22|P-value:3.87E-7 ID:SGTC_2276|Compound:7947513|FD-Score:-4.62|P-value:6.14E-6 ID:SGTC_2284|Compound:7945075|FD-Score:5.33|P-value:2.32E-7 ID:SGTC_2289|Compound:7946404|FD-Score:-4.38|P-value:1.70E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.57|P-value:3.71E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.71|P-value:2.22E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.76|P-value:1.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.46|P-value:5.33E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.98|P-value:7.91E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.00|P-value:1.55E-21 ID:SGTC_2715|Compound:st079500|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.18|P-value:3.92E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.22|P-value:3.28E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.76|P-value:1.91E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.77|P-value:2.45E-8 ID:SGTC_2831|Compound:7999036|FD-Score:-3.76|P-value:1.85E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.51|P-value:4.57E-4 ID:SGTC_2881|Compound:9058953|FD-Score:4.15|P-value:4.36E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.59|P-value:7.12E-6 ID:SGTC_2902|Compound:5787006|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.66|P-value:2.13E-13 ID:SGTC_3011|Compound:9081274|FD-Score:3.44|P-value:5.73E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.60|P-value:3.25E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-5.06|P-value:8.39E-7 ID:SGTC_3121|Compound:9125696|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.84|P-value:2.36E-6 ID:SGTC_3150|Compound:9097574|FD-Score:3.35|P-value:7.58E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.84|P-value:1.41E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.50|P-value:1.04E-5 ID:SGTC_3266|Compound:9136860|FD-Score:5.97|P-value:8.22E-9 ID:SGTC_3280|Compound:9140961|FD-Score:3.35|P-value:7.73E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.39|P-value:6.62E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.41|P-value:8.77E-16 ID:SGTC_56|Compound:0957-0365|FD-Score:12.40|P-value:7.02E-32 ID:SGTC_58|Compound:0957-0393|FD-Score:6.91|P-value:3.06E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:4.81|P-value:2.69E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:3.59|P-value:3.43E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.07|P-value:5.85E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.65|P-value:4.56E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.10|P-value:7.05E-7 ID:SGTC_228|Compound:caffeine|FD-Score:4.86|P-value:2.13E-6 ID:SGTC_251|Compound:melphalan|FD-Score:4.02|P-value:7.07E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:4.22|P-value:3.33E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.74|P-value:3.67E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.76|P-value:2.56E-8 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.50|P-value:6.64E-13 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.75|P-value:1.97E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.68|P-value:4.82E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:3.54|P-value:4.06E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.60|P-value:6.90E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:3.90|P-value:1.12E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.35|P-value:7.63E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.62|P-value:3.13E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.52|P-value:4.29E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:9.49|P-value:1.41E-19 ID:SGTC_976|Compound:1348-1067|FD-Score:3.35|P-value:7.79E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.29|P-value:9.16E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.80|P-value:1.65E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.32|P-value:8.35E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.48|P-value:5.00E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.87|P-value:1.28E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.57|P-value:3.73E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.72|P-value:2.19E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.83|P-value:1.43E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.51|P-value:4.43E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.07|P-value:5.89E-5 ID:SGTC_1781|Compound:st038725|FD-Score:5.82|P-value:1.84E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:17.40|P-value:7.52E-61 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.68|P-value:1.81E-13 ID:SGTC_1917|Compound:st066507|FD-Score:4.67|P-value:5.05E-6 ID:SGTC_2026|Compound:5148700|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.37|P-value:7.08E-4 ID:SGTC_2177|Compound:5811945|FD-Score:11.50|P-value:8.38E-28 ID:SGTC_2186|Compound:6124449|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_2264|Compound:7948757|FD-Score:5.22|P-value:3.87E-7 ID:SGTC_2276|Compound:7947513|FD-Score:-4.62|P-value:6.14E-6 ID:SGTC_2284|Compound:7945075|FD-Score:5.33|P-value:2.32E-7 ID:SGTC_2289|Compound:7946404|FD-Score:-4.38|P-value:1.70E-5 ID:SGTC_2360|Compound:9040895|FD-Score:3.57|P-value:3.71E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.71|P-value:2.22E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.76|P-value:1.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:2.68E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.46|P-value:5.33E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.98|P-value:7.91E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.00|P-value:1.55E-21 ID:SGTC_2715|Compound:st079500|FD-Score:3.32|P-value:8.51E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.18|P-value:3.92E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.22|P-value:3.28E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.76|P-value:1.91E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.77|P-value:2.45E-8 ID:SGTC_2831|Compound:7999036|FD-Score:-3.76|P-value:1.85E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.51|P-value:4.57E-4 ID:SGTC_2881|Compound:9058953|FD-Score:4.15|P-value:4.36E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.59|P-value:7.12E-6 ID:SGTC_2902|Compound:5787006|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.66|P-value:2.13E-13 ID:SGTC_3011|Compound:9081274|FD-Score:3.44|P-value:5.73E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.60|P-value:3.25E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-5.06|P-value:8.39E-7 ID:SGTC_3121|Compound:9125696|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.84|P-value:2.36E-6 ID:SGTC_3150|Compound:9097574|FD-Score:3.35|P-value:7.58E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.84|P-value:1.41E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.50|P-value:1.04E-5 ID:SGTC_3266|Compound:9136860|FD-Score:5.97|P-value:8.22E-9 ID:SGTC_3280|Compound:9140961|FD-Score:3.35|P-value:7.73E-4

Top fitness defect scores for YKR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 17.40 4.0 nM 7.52E-61 10 9.80E-68
2 SGTC_56 0957-0365 12.40 83.2 µM 7.02E-32 Golgi 3 2.19E-35
3 SGTC_2177 5811945 11.50 192.0 µM 8.38E-28 1 7.79E-31
4 SGTC_2679 rapamycin 10.00 1.0 nM 1.55E-21 26 7.71E-24
5 SGTC_893 0958-0369 9.49 48.9 µM 1.41E-19 1 1.18E-21
6 SGTC_46 0329-0187a 8.41 2.2 µM 8.77E-16 13 2.02E-17
7 SGTC_1877 wortmannin 7.68 25.0 µM 1.81E-13 24 7.72E-15
8 SGTC_2912 7964298 7.66 10.9 µM 2.13E-13 cell wall 29 9.23E-15
9 SGTC_451 chloral hydrate 7.50 100.0 µM 6.64E-13 8 3.29E-14
10 SGTC_58 0957-0393 6.91 9.0 µM 3.06E-11 cell wall 167 2.35E-12
11 SGTC_2651 1327-0036 5.98 5.0 µM 7.91E-9 74 1.15E-9
12 SGTC_3266 9136860 5.97 49.5 µM 8.22E-9 cell wall 17 1.20E-9
13 SGTC_1781 st038725 5.82 66.3 µM 1.84E-8 NEO1 59 2.94E-9
14 SGTC_2772 vinpocetine 5.77 57.1 µM 2.45E-8 5 4.05E-9
15 SGTC_449 xestospongin c 5.76 11.2 µM 2.56E-8 NEO1-PIK1 21 4.25E-9
16 SGTC_138 0850-0259 5.65 40.9 µM 4.56E-8 cell wall 118 8.09E-9
17 SGTC_2284 7945075 5.33 39.2 µM 2.32E-7 mitochondrial processes 7 4.95E-8
18 SGTC_2264 7948757 5.22 110.8 µM 3.87E-7 4 8.75E-8
19 SGTC_221 trifluoperazine 5.10 10.3 µM 7.05E-7 NEO1-PIK1 154 1.70E-7
20 SGTC_228 caffeine 4.86 993.1 µM 2.13E-6 6 5.84E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.528 8.34E-240 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.461 1.67E-175 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.461 1.02E-175 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.340 1.11E-91 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.311 2.61E-76 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.296 5.52E-69 YPL180W TCO89 hom Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
0.296 9.42E-69 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.292 5.06E-67 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.281 5.64E-62 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.278 1.73E-60 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.265 4.41E-55 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.243 3.00E-46 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.237 5.53E-44 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.221 4.36E-38 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.213 1.59E-35 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress