YKR008W / RSC4

Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR008W / RSC4

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.30|P-value:3.67E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:5.45|P-value:1.76E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:6.13|P-value:5.17E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:-4.78|P-value:4.48E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.44|P-value:7.13E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.57|P-value:9.42E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:3.45|P-value:6.26E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.43|P-value:1.93E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:4.01|P-value:8.70E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:5.79|P-value:3.11E-8 ID:SGTC_342|Compound:k048-0088|FD-Score:3.77|P-value:2.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.40|P-value:8.11E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.58|P-value:9.09E-8 ID:SGTC_547|Compound:1120-0019|FD-Score:5.04|P-value:1.20E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:4.00|P-value:8.95E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.82|P-value:2.63E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:3.81|P-value:1.82E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.62|P-value:3.46E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:8.22|P-value:8.30E-15 ID:SGTC_1044|Compound:1222-0021|FD-Score:11.00|P-value:6.42E-25 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.35|P-value:2.82E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.41|P-value:7.90E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.27|P-value:3.29E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.30|P-value:9.92E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.41|P-value:7.75E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.45|P-value:7.00E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.57|P-value:4.70E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.52|P-value:4.86E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.73|P-value:2.38E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.31|P-value:2.76E-5 ID:SGTC_1783|Compound:st039459|FD-Score:4.41|P-value:1.89E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.21|P-value:4.05E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-3.48|P-value:6.30E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.63|P-value:6.96E-8 ID:SGTC_1921|Compound:5740136|FD-Score:5.60|P-value:8.49E-8 ID:SGTC_1923|Compound:st058458|FD-Score:7.52|P-value:1.12E-12 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.25|P-value:3.52E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-6.05|P-value:9.57E-9 ID:SGTC_2066|Compound:5222451|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_2225|Compound:6654152|FD-Score:8.92|P-value:4.16E-17 ID:SGTC_2248|Compound:tofa|FD-Score:3.33|P-value:8.94E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.23|P-value:3.45E-18 ID:SGTC_2336|Compound:9001819|FD-Score:4.11|P-value:5.94E-5 ID:SGTC_2344|Compound:7990960|FD-Score:6.51|P-value:5.79E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.40|P-value:1.91E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.74|P-value:2.61E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.55|P-value:4.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.54|P-value:1.08E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.13|P-value:6.24E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-4.84|P-value:3.57E-6 ID:SGTC_2812|Compound:7970281|FD-Score:3.33|P-value:9.14E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.85|P-value:1.77E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.03|P-value:1.27E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.43|P-value:6.56E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.28|P-value:3.17E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.49|P-value:6.11E-4 ID:SGTC_2930|Compound:9013230|FD-Score:7.57|P-value:7.70E-13 ID:SGTC_2993|Compound:9054257|FD-Score:3.72|P-value:2.48E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.93|P-value:1.16E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.08|P-value:6.78E-9 ID:SGTC_3191|Compound:9110352|FD-Score:-4.26|P-value:3.88E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.21|P-value:4.06E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.86|P-value:2.77E-6 ID:SGTC_3340|Compound:9146634|FD-Score:-3.46|P-value:6.70E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:5.30|P-value:3.67E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:5.45|P-value:1.76E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:6.13|P-value:5.17E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:-4.78|P-value:4.48E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.44|P-value:7.13E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.57|P-value:9.42E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:3.45|P-value:6.26E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:5.43|P-value:1.93E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:4.01|P-value:8.70E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:5.79|P-value:3.11E-8 ID:SGTC_342|Compound:k048-0088|FD-Score:3.77|P-value:2.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.40|P-value:8.11E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.58|P-value:9.09E-8 ID:SGTC_547|Compound:1120-0019|FD-Score:5.04|P-value:1.20E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:4.00|P-value:8.95E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.82|P-value:2.63E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:3.81|P-value:1.82E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.62|P-value:3.46E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.58|P-value:3.96E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:8.22|P-value:8.30E-15 ID:SGTC_1044|Compound:1222-0021|FD-Score:11.00|P-value:6.42E-25 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.35|P-value:2.82E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.41|P-value:7.90E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.27|P-value:3.29E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.30|P-value:9.92E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.31|P-value:9.55E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.41|P-value:7.75E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.45|P-value:7.00E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.57|P-value:4.70E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.52|P-value:4.86E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.73|P-value:2.38E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.31|P-value:2.76E-5 ID:SGTC_1783|Compound:st039459|FD-Score:4.41|P-value:1.89E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.21|P-value:4.05E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-3.48|P-value:6.30E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.63|P-value:6.96E-8 ID:SGTC_1921|Compound:5740136|FD-Score:5.60|P-value:8.49E-8 ID:SGTC_1923|Compound:st058458|FD-Score:7.52|P-value:1.12E-12 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.25|P-value:3.52E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-6.05|P-value:9.57E-9 ID:SGTC_2066|Compound:5222451|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_2225|Compound:6654152|FD-Score:8.92|P-value:4.16E-17 ID:SGTC_2248|Compound:tofa|FD-Score:3.33|P-value:8.94E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.23|P-value:3.45E-18 ID:SGTC_2336|Compound:9001819|FD-Score:4.11|P-value:5.94E-5 ID:SGTC_2344|Compound:7990960|FD-Score:6.51|P-value:5.79E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.40|P-value:1.91E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.74|P-value:2.61E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.55|P-value:4.98E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.54|P-value:1.08E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.13|P-value:6.24E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-4.84|P-value:3.57E-6 ID:SGTC_2812|Compound:7970281|FD-Score:3.33|P-value:9.14E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.85|P-value:1.77E-4 ID:SGTC_2856|Compound:9022925|FD-Score:5.03|P-value:1.27E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.43|P-value:6.56E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.28|P-value:3.17E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.49|P-value:6.11E-4 ID:SGTC_2930|Compound:9013230|FD-Score:7.57|P-value:7.70E-13 ID:SGTC_2993|Compound:9054257|FD-Score:3.72|P-value:2.48E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.93|P-value:1.16E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.08|P-value:6.78E-9 ID:SGTC_3191|Compound:9110352|FD-Score:-4.26|P-value:3.88E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.21|P-value:4.06E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.86|P-value:2.77E-6 ID:SGTC_3340|Compound:9146634|FD-Score:-3.46|P-value:6.70E-4

Top fitness defect scores for YKR008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1044 1222-0021 11.00 1.8 µM 6.42E-25 heme biosynthesis & mitochondrial translocase 4 2.51E-28 1.19
2 SGTC_2322 7413319 9.23 38.2 µM 3.45E-18 ERAD & cell cycle 7 1.34E-20 1.81
3 SGTC_2225 6654152 8.92 15.4 µM 4.16E-17 11 2.35E-19 0.42
4 SGTC_1036 k216-0215 8.22 33.5 µM 8.30E-15 mitochondrial response to ROS 1 1.02E-16 3.00
5 SGTC_2930 9013230 7.57 14.9 µM 7.70E-13 heme biosynthesis & mitochondrial translocase 8 1.84E-14 0.59
6 SGTC_1923 st058458 7.52 19.1 µM 1.12E-12 1 2.83E-14 0.92
7 SGTC_2344 7990960 6.51 77.0 µM 5.79E-10 16 3.64E-11 0.21
8 SGTC_69 0096-0274 6.13 206.7 µM 5.17E-9 mitochondrial processes 22 4.47E-10 0.30
9 SGTC_3081 9117243 6.08 49.5 µM 6.78E-9 fatty acid desaturase (OLE1) 12 6.10E-10 0.22
10 SGTC_902 1120-0002 5.82 2.1 µM 2.63E-8 azole & statin 8 2.87E-9 0.26
11 SGTC_331 k048-0133 5.79 24.5 µM 3.11E-8 RSC & ERG11 2 3.49E-9 0.75
12 SGTC_1920 st075728 5.63 45.7 µM 6.96E-8 1 8.76E-9 0.93
13 SGTC_1921 5740136 5.60 50.0 µM 8.49E-8 TRP & mitochondrial translation 6 1.10E-8 0.12
14 SGTC_525 k781-2675 5.58 26.7 µM 9.09E-8 redox potentiating 26 1.19E-8 0.00
15 SGTC_91 0417-1751 5.57 58.4 µM 9.42E-8 Golgi 5 1.24E-8 0.50
16 SGTC_16 erodoxin 5.45 22.8 µM 1.76E-7 unfolded protein response 14 2.54E-8 0.18
17 SGTC_262 fenpropimorph 5.43 62.5 µM 1.93E-7 ergosterol depletion effects on membrane 9 2.82E-8 0.53
18 SGTC_1098 clofazimine 5.35 15.1 µM 2.82E-7 heme biosynthesis & mitochondrial translocase 12 4.35E-8 0.05
19 SGTC_1 0258-0098 5.30 57.4 µM 3.67E-7 heme biosynthesis & mitochondrial translocase 11 5.86E-8 0.20
20 SGTC_547 1120-0019 5.04 610.0 nM 1.20E-6 azole & statin 5 2.27E-7 1.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.302 1.19E-71 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.270 3.92E-57 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.235 1.98E-43 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.221 2.81E-38 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.212 1.48E-35 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.206 2.99E-33 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.205 4.06E-33 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.204 7.78E-33 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.192 4.38E-29 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.189 1.83E-28 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.182 2.81E-26 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.180 7.35E-26 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.175 1.64E-24 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.172 1.14E-23 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.170 4.76E-23 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)