YKR013W / PRY2

Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR013W / PRY2

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:-4.09|P-value:1.27E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.83|P-value:3.24E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.14|P-value:1.15E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.86|P-value:2.90E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:7.23|P-value:5.63E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:3.73|P-value:4.54E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.46|P-value:3.57E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.55|P-value:7.83E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.58|P-value:7.27E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:9.15E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.79|P-value:9.92E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.14|P-value:1.12E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.46|P-value:9.86E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.27|P-value:7.04E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.26|P-value:7.30E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-6.73|P-value:8.87E-10 ID:SGTC_1855|Compound:st056195|FD-Score:3.66|P-value:5.54E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.29|P-value:6.20E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.25|P-value:7.74E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.21|P-value:8.91E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.85|P-value:7.80E-6 ID:SGTC_2294|Compound:7971431|FD-Score:4.35|P-value:5.44E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.64|P-value:6.01E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.71|P-value:4.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.60|P-value:6.72E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.59|P-value:6.63E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.70|P-value:4.65E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.76|P-value:4.07E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.92|P-value:2.40E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.52|P-value:2.88E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.90|P-value:2.41E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-4.09|P-value:1.27E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.83|P-value:3.24E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:4.14|P-value:1.15E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.98|P-value:1.97E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.86|P-value:2.90E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:7.23|P-value:5.63E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:3.73|P-value:4.54E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.46|P-value:3.57E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.55|P-value:7.83E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.58|P-value:7.27E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:9.15E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.79|P-value:9.92E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.14|P-value:1.12E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.46|P-value:9.86E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.27|P-value:7.04E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.26|P-value:7.30E-5 ID:SGTC_1849|Compound:st056239|FD-Score:-6.73|P-value:8.87E-10 ID:SGTC_1855|Compound:st056195|FD-Score:3.66|P-value:5.54E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.29|P-value:6.20E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.25|P-value:7.74E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.21|P-value:8.91E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.85|P-value:7.80E-6 ID:SGTC_2294|Compound:7971431|FD-Score:4.35|P-value:5.44E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.64|P-value:6.01E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.71|P-value:4.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.60|P-value:6.72E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.59|P-value:6.63E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.70|P-value:4.65E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.76|P-value:4.07E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.92|P-value:2.40E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.52|P-value:2.88E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.90|P-value:2.41E-4

Top fitness defect scores for YKR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_789 1309-1135 7.23 70.6 µM 5.63E-11 ERG2 4 2.33E-13
2 SGTC_1950 st077106 4.85 7.2 µM 7.80E-6 RNA processing & uracil transport 13 6.19E-7
3 SGTC_1187 1391-0724 4.79 117.0 µM 9.92E-6 amide catabolism 8 8.36E-7
4 SGTC_3307 9126885 4.52 69.3 µM 2.88E-5 22 3.16E-6
5 SGTC_821 1114-0266 4.46 29.2 µM 3.57E-5 12 4.11E-6
6 SGTC_2294 7971431 4.35 200.0 µM 5.44E-5 8 6.95E-6
7 SGTC_1573 oleylamine 4.27 1.1 µM 7.04E-5 21 9.59E-6
8 SGTC_1763 st044482 4.26 94.5 µM 7.30E-5 copper-dependent oxidative stress 18 1.00E-5
9 SGTC_1928 4'-methoxychalcone 4.25 40.3 µM 7.74E-5 6 1.08E-5
10 SGTC_1930 st074634 4.21 34.3 µM 8.91E-5 RNA pol III & RNase P/MRP 30 1.29E-5
11 SGTC_1205 4161-2785 4.14 76.0 µM 1.12E-4 24 1.70E-5
12 SGTC_285 1486-1325 4.14 46.0 µM 1.15E-4 17 1.77E-5
13 SGTC_764 1951-2361 3.98 146.0 µM 1.97E-4 35 3.46E-5
14 SGTC_3035 9091303 3.92 49.5 µM 2.40E-4 7 4.41E-5
15 SGTC_777 1315-0167 3.86 517.0 µM 2.90E-4 Golgi 27 5.58E-5
16 SGTC_162 k030-0015 3.83 37.8 µM 3.24E-4 iron homeostasis 23 6.39E-5
17 SGTC_2990 9074105 3.76 71.4 µM 4.07E-4 6 8.48E-5
18 SGTC_814 3342-0569 3.73 96.0 µM 4.54E-4 24 9.73E-5
19 SGTC_2379 9035213 3.71 200.0 µM 4.75E-4 30 1.03E-4
20 SGTC_1855 st056195 3.66 39.6 µM 5.54E-4 60S ribosome export 25 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.80E-16 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.136 2.60E-15 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.095 3.02E-8 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.094 4.54E-8 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.092 8.69E-8 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.087 4.11E-7 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.087 4.69E-7 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 5.74E-7 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.080 3.08E-6 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.079 4.19E-6 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.076 1.14E-5 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.075 1.31E-5 YCR101C_p YCR101C_p hom Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
0.075 1.49E-5 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.074 1.67E-5 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.072 2.94E-5 YKL033W TTI1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies