YKR016W / FCJ1

Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR016W / FCJ1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.82|P-value:5.71E-12 ID:SGTC_114|Compound:0364-0001|FD-Score:3.80|P-value:6.08E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:9.04|P-value:5.13E-20 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.23|P-value:1.41E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.30|P-value:9.99E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.28|P-value:1.19E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.37|P-value:3.05E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.01|P-value:2.53E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.27|P-value:4.70E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.38|P-value:4.75E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.71|P-value:8.72E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.70|P-value:9.01E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.13|P-value:9.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.12|P-value:7.90E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.80|P-value:6.04E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.65|P-value:1.37E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:6.82|P-value:3.34E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:4.29|P-value:7.18E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.74|P-value:7.72E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.35|P-value:5.61E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.74|P-value:7.89E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.91|P-value:3.79E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.21|P-value:1.07E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.73|P-value:3.78E-9 ID:SGTC_1661|Compound:st013063|FD-Score:3.15|P-value:6.93E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.39|P-value:2.71E-8 ID:SGTC_1831|Compound:st055328|FD-Score:3.87|P-value:4.60E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.29|P-value:5.71E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.31|P-value:5.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.15|P-value:9.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.39|P-value:4.71E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.20|P-value:7.96E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.69|P-value:9.44E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-4.03|P-value:3.34E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.65|P-value:1.50E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.17|P-value:8.67E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.60|P-value:2.55E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.95|P-value:2.90E-7 ID:SGTC_3255|Compound:9139072|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.12|P-value:7.76E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.62|P-value:1.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.82|P-value:5.71E-12 ID:SGTC_114|Compound:0364-0001|FD-Score:3.80|P-value:6.08E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:9.04|P-value:5.13E-20 ID:SGTC_177|Compound:1327-0068|FD-Score:-4.23|P-value:1.41E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.30|P-value:9.99E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.28|P-value:1.19E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.37|P-value:3.05E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.01|P-value:2.53E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.27|P-value:4.70E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.38|P-value:4.75E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.21|P-value:1.05E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.71|P-value:8.72E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.70|P-value:9.01E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.13|P-value:9.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.12|P-value:7.90E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.80|P-value:6.04E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.65|P-value:1.37E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:6.82|P-value:3.34E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:4.29|P-value:7.18E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:3.74|P-value:7.72E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.19|P-value:6.13E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.35|P-value:5.61E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.74|P-value:7.89E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.91|P-value:3.79E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.21|P-value:1.07E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.73|P-value:3.78E-9 ID:SGTC_1661|Compound:st013063|FD-Score:3.15|P-value:6.93E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.39|P-value:2.71E-8 ID:SGTC_1831|Compound:st055328|FD-Score:3.87|P-value:4.60E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.29|P-value:5.71E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.31|P-value:5.41E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.15|P-value:9.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.14|P-value:1.45E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.39|P-value:4.71E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.20|P-value:7.96E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.69|P-value:9.44E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-4.03|P-value:3.34E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.65|P-value:1.50E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.17|P-value:8.67E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.60|P-value:2.55E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.95|P-value:2.90E-7 ID:SGTC_3255|Compound:9139072|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.22|P-value:5.59E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.12|P-value:7.76E-4

Top fitness defect scores for YKR016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_115 0527-0192 9.04 112.0 µM 5.13E-20 7 7.86E-20
2 SGTC_236 1509-0011 7.28 5.3 µM 1.19E-13 262 1.66E-13
3 SGTC_778 3456-2434 6.82 196.0 µM 3.34E-12 mitochondrial response to ROS 19 4.57E-12
4 SGTC_1635 st007035 5.73 42.4 µM 3.78E-9 139 4.92E-9
5 SGTC_1809 st050081 5.39 57.6 µM 2.71E-8 6 3.48E-8
6 SGTC_275 trichlorophene 5.37 5.7 µM 3.05E-8 mitochondrial stress 144 3.90E-8
7 SGTC_3170 9103054 4.95 49.5 µM 2.90E-7 60S ribosome export 3 3.64E-7
8 SGTC_743 1275-0778 4.65 158.0 µM 1.37E-6 excess fatty acid 22 1.70E-6
9 SGTC_2589 lobaric acid 4.39 100.0 µM 4.71E-6 19 5.76E-6
10 SGTC_365 0121-0052 4.38 13.6 µM 4.75E-6 mitochondrial response to ROS 44 5.81E-6
11 SGTC_1171 0368-0077 4.35 21.4 µM 5.61E-6 16 6.85E-6
12 SGTC_788 1182-0090 4.29 188.0 µM 7.18E-6 endomembrane recycling 70 8.74E-6
13 SGTC_530 4358-1714 4.21 28.0 µM 1.05E-5 40 1.28E-5
14 SGTC_1338 1486-1223 4.21 76.0 µM 1.07E-5 14 1.30E-5
15 SGTC_2541 muurolladie-3-one 4.14 83.1 µM 1.45E-5 excess fatty acid 23 1.75E-5
16 SGTC_335 4077-0256 4.01 27.6 µM 2.53E-5 16 3.04E-5
17 SGTC_1250 0485-0349 3.91 40.2 µM 3.79E-5 37 4.54E-5
18 SGTC_1831 st055328 3.87 12.0 µM 4.60E-5 heme biosynthesis & mitochondrial translocase 28 5.50E-5
19 SGTC_733 4069-0007 3.80 56.1 µM 6.04E-5 ERAD & cell cycle 92 7.20E-5
20 SGTC_114 0364-0001 3.80 490.3 µM 6.08E-5 58 7.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.276 1.13E-59 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.275 3.04E-59 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.267 6.49E-56 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.265 3.63E-55 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.261 4.16E-53 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.259 1.78E-52 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.258 2.41E-52 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.253 4.95E-50 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.248 3.21E-48 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.246 1.83E-47 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.236 1.23E-43 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.236 1.45E-43 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.235 2.21E-43 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.233 1.29E-42 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.232 3.40E-42 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex