HIPHOP chemogenomics database

YKR016W / FCJ1

Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane

Zygosity: Homozygous strain

fixedexpanded
Profile for YKR016W / FCJ1

Click on Significant Values for Screen Details

Top fitness defect scores for YKR016W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_115	0527-0192	9.04	112.0 µM	5.13E-20		7	7.86E-20
2	SGTC_236	1509-0011	7.28	5.3 µM	1.19E-13		262	1.66E-13
3	SGTC_778	3456-2434	6.82	196.0 µM	3.34E-12	mitochondrial response to ROS	19	4.57E-12
4	SGTC_1635	st007035	5.73	42.4 µM	3.78E-9		139	4.92E-9
5	SGTC_1809	st050081	5.39	57.6 µM	2.71E-8		6	3.48E-8
6	SGTC_275	trichlorophene	5.37	5.7 µM	3.05E-8	mitochondrial stress	144	3.90E-8
7	SGTC_3170	9103054	4.95	49.5 µM	2.90E-7	60S ribosome export	3	3.64E-7
8	SGTC_743	1275-0778	4.65	158.0 µM	1.37E-6	excess fatty acid	22	1.70E-6
9	SGTC_2589	lobaric acid	4.39	100.0 µM	4.71E-6		19	5.76E-6
10	SGTC_365	0121-0052	4.38	13.6 µM	4.75E-6	mitochondrial response to ROS	44	5.81E-6
11	SGTC_1171	0368-0077	4.35	21.4 µM	5.61E-6		16	6.85E-6
12	SGTC_788	1182-0090	4.29	188.0 µM	7.18E-6	endomembrane recycling	70	8.74E-6
13	SGTC_530	4358-1714	4.21	28.0 µM	1.05E-5		40	1.28E-5
14	SGTC_1338	1486-1223	4.21	76.0 µM	1.07E-5		14	1.30E-5
15	SGTC_2541	muurolladie-3-one	4.14	83.1 µM	1.45E-5	excess fatty acid	23	1.75E-5
16	SGTC_335	4077-0256	4.01	27.6 µM	2.53E-5		16	3.04E-5
17	SGTC_1250	0485-0349	3.91	40.2 µM	3.79E-5		37	4.54E-5
18	SGTC_1831	st055328	3.87	12.0 µM	4.60E-5	heme biosynthesis & mitochondrial translocase	28	5.50E-5
19	SGTC_733	4069-0007	3.80	56.1 µM	6.04E-5	ERAD & cell cycle	92	7.20E-5
20	SGTC_114	0364-0001	3.80	490.3 µM	6.08E-5		58	7.25E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.276	1.13E-59	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.275	3.04E-59	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.267	6.49E-56	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.265	3.63E-55	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.261	4.16E-53	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.259	1.78E-52	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.258	2.41E-52	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.253	4.95E-50	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.248	3.21E-48	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.246	1.83E-47	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.236	1.23E-43	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.236	1.45E-43	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.235	2.21E-43	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.233	1.29E-42	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.232	3.40E-42	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex