YKR018C

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR018C / YKR018C

Click on Significant Values for Screen Details

Top fitness defect scores for YKR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2418 pentamidine 17.80 31.7 µM 1.12E-75 mitochondrial processes 1 5.97E-71
2 SGTC_1368 1852-0141 6.51 284.0 µM 8.95E-12 ERG2 6 3.78E-11
3 SGTC_1011 4112-3381 5.93 17.4 µM 4.60E-10 12 1.52E-9
4 SGTC_1293 1000-1278 4.31 195.0 µM 4.28E-6 5 8.05E-6
5 SGTC_2682 pyrogallin 4.20 40.0 µM 7.39E-6 copper-dependent oxidative stress 22 1.34E-5
6 SGTC_2021 4019055 4.15 173.0 µM 9.45E-6 endomembrane recycling 112 1.69E-5
7 SGTC_2337 9009472 3.95 200.0 µM 2.27E-5 33 3.86E-5
8 SGTC_1527 coumarin 3.93 137.0 µM 2.51E-5 26 4.24E-5
9 SGTC_1026 k007-1105 3.92 30.6 µM 2.65E-5 ERAD & cell cycle 96 4.46E-5
10 SGTC_1718 roemerine 3.82 11.9 µM 4.07E-5 redox potentiating 60 6.69E-5
11 SGTC_3284 9108171 3.80 64.9 µM 4.37E-5 28 7.15E-5
12 SGTC_2718 lomofungin 3.57 53.0 µM 1.16E-4 mitochondrial processes 19 1.79E-4
13 SGTC_2321 7390090 3.55 138.8 µM 1.24E-4 40 1.91E-4
14 SGTC_2017 5132927 3.52 60.6 µM 1.44E-4 42 2.19E-4
15 SGTC_763 3453-1109 3.50 128.0 µM 1.50E-4 34 2.28E-4
16 SGTC_2842 9000675 3.46 19.5 µM 1.77E-4 40 2.66E-4
17 SGTC_2678 equilin 3.46 100.0 µM 1.78E-4 35 2.67E-4
18 SGTC_2414 st077232 3.44 92.9 µM 1.96E-4 38 2.92E-4
19 SGTC_402 epigallocatechin gallate 3.37 10.0 µM 2.54E-4 60 3.74E-4
20 SGTC_2792 7535235 3.29 81.8 µM 3.48E-4 fatty acid desaturase (OLE1) 58 5.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 7.10E-32 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.189 2.69E-28 YMR175W SIP18 hom Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress
0.188 4.01E-28 YLR005W SSL1 het Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
0.187 9.59E-28 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.179 1.88E-25 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.142 1.35E-16 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.116 1.42E-11 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.116 1.71E-11 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.113 4.54E-11 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.113 5.77E-11 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.112 8.55E-11 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.108 4.25E-10 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.107 4.23E-10 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.105 9.04E-10 YLR219W MSC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress
0.103 2.23E-9 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74