YKR019C / IRS4

EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR019C / IRS4

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:7.28|P-value:4.74E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:17.30|P-value:2.15E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:8.80|P-value:3.24E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:7.27|P-value:4.81E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:10.00|P-value:2.70E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:13.30|P-value:8.10E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:31.90|P-value:8.91E-48 ID:SGTC_232|Compound:clozapine|FD-Score:23.60|P-value:3.65E-27 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.32|P-value:7.95E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:7.95|P-value:1.53E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:7.96|P-value:1.51E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-8.35|P-value:7.37E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:8.23|P-value:9.34E-5 ID:SGTC_459|Compound:nigericin|FD-Score:9.40|P-value:9.92E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.88|P-value:3.61E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:7.29|P-value:4.71E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:8.35|P-value:7.50E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:-7.17|P-value:5.53E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:13.40|P-value:5.45E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:9.50|P-value:8.06E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:7.01|P-value:7.34E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:11.20|P-value:1.64E-7 ID:SGTC_798|Compound:1287-0182|FD-Score:9.35|P-value:1.09E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:7.81|P-value:1.95E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:7.52|P-value:3.21E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:7.22|P-value:5.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-6.82|P-value:9.64E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.62|P-value:4.53E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.55|P-value:3.03E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:7.77|P-value:2.09E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:9.38|P-value:1.02E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:22.90|P-value:1.11E-25 ID:SGTC_1078|Compound:idebenone|FD-Score:8.03|P-value:1.33E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:8.07|P-value:1.25E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-7.30|P-value:4.47E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:7.55|P-value:3.04E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:8.40|P-value:6.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.96|P-value:7.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-7.08|P-value:6.43E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:11.60|P-value:7.33E-8 ID:SGTC_1478|Compound:0453-0656|FD-Score:7.72|P-value:2.27E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:8.62|P-value:4.52E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:7.35|P-value:4.21E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:9.28|P-value:1.26E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.53|P-value:3.16E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:8.51|P-value:5.56E-5 ID:SGTC_1655|Compound:st012546|FD-Score:8.08|P-value:1.23E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.20|P-value:2.02E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-7.15|P-value:5.76E-4 ID:SGTC_1751|Compound:st044839|FD-Score:8.33|P-value:7.77E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-6.94|P-value:7.96E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-9.15|P-value:1.60E-5 ID:SGTC_1917|Compound:st066507|FD-Score:9.29|P-value:1.23E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-7.31|P-value:4.40E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-7.26|P-value:4.83E-4 ID:SGTC_1953|Compound:st076800|FD-Score:9.95|P-value:3.15E-6 ID:SGTC_1972|Compound:st070201|FD-Score:8.10|P-value:1.19E-4 ID:SGTC_1975|Compound:st070967|FD-Score:11.30|P-value:1.30E-7 ID:SGTC_1991|Compound:st073000|FD-Score:7.45|P-value:3.60E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-8.12|P-value:1.10E-4 ID:SGTC_2013|Compound:4024628|FD-Score:13.10|P-value:1.31E-9 ID:SGTC_2030|Compound:5175110|FD-Score:7.26|P-value:4.94E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-6.86|P-value:9.00E-4 ID:SGTC_2041|Compound:5107442|FD-Score:10.70|P-value:6.56E-7 ID:SGTC_2254|Compound:7938975|FD-Score:11.60|P-value:6.79E-8 ID:SGTC_2255|Compound:7941087|FD-Score:13.60|P-value:3.28E-10 ID:SGTC_2268|Compound:7933382|FD-Score:8.12|P-value:1.14E-4 ID:SGTC_2271|Compound:7849410|FD-Score:7.83|P-value:1.89E-4 ID:SGTC_2277|Compound:7947813|FD-Score:10.70|P-value:6.29E-7 ID:SGTC_2278|Compound:7948257|FD-Score:7.26|P-value:4.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:13.90|P-value:1.38E-10 ID:SGTC_2332|Compound:7982454|FD-Score:9.41|P-value:9.67E-6 ID:SGTC_2340|Compound:7987427|FD-Score:6.93|P-value:8.34E-4 ID:SGTC_2366|Compound:9070441|FD-Score:9.21|P-value:1.45E-5 ID:SGTC_2399|Compound:5884133|FD-Score:7.22|P-value:5.25E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.21|P-value:5.32E-4 ID:SGTC_2444|Compound:5485484|FD-Score:7.91|P-value:1.66E-4 ID:SGTC_2460|Compound:5552655|FD-Score:10.60|P-value:7.17E-7 ID:SGTC_2472|Compound:5377652|FD-Score:8.88|P-value:2.76E-5 ID:SGTC_2488|Compound:5268135|FD-Score:10.30|P-value:1.39E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:9.15|P-value:1.63E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.48|P-value:3.40E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:9.20|P-value:1.48E-5 ID:SGTC_2695|Compound:st077686|FD-Score:7.73|P-value:2.24E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.70|P-value:6.10E-8 ID:SGTC_2838|Compound:9002687|FD-Score:-7.85|P-value:1.79E-4 ID:SGTC_2873|Compound:9040596|FD-Score:8.71|P-value:3.80E-5 ID:SGTC_2942|Compound:9052777|FD-Score:8.17|P-value:1.05E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-7.51|P-value:3.21E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.78|P-value:2.07E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-7.48|P-value:3.36E-4 ID:SGTC_3098|Compound:9119039|FD-Score:8.89|P-value:2.74E-5 ID:SGTC_3128|Compound:9127691|FD-Score:7.33|P-value:4.35E-4 ID:SGTC_3166|Compound:9102297|FD-Score:8.21|P-value:9.69E-5 ID:SGTC_3189|Compound:9110682|FD-Score:7.53|P-value:3.16E-4 ID:SGTC_3292|Compound:9120825|FD-Score:8.73|P-value:3.68E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:7.28|P-value:4.74E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:17.30|P-value:2.15E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:8.80|P-value:3.24E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:7.27|P-value:4.81E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:10.00|P-value:2.70E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:13.30|P-value:8.10E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:31.90|P-value:8.91E-48 ID:SGTC_232|Compound:clozapine|FD-Score:23.60|P-value:3.65E-27 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.32|P-value:7.95E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:7.95|P-value:1.53E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:7.96|P-value:1.51E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-8.35|P-value:7.37E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:8.23|P-value:9.34E-5 ID:SGTC_459|Compound:nigericin|FD-Score:9.40|P-value:9.92E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:9.88|P-value:3.61E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:7.29|P-value:4.71E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:8.35|P-value:7.50E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:-7.17|P-value:5.53E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:13.40|P-value:5.45E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:9.50|P-value:8.06E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:7.01|P-value:7.34E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:11.20|P-value:1.64E-7 ID:SGTC_798|Compound:1287-0182|FD-Score:9.35|P-value:1.09E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:7.81|P-value:1.95E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:7.52|P-value:3.21E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:7.22|P-value:5.21E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-6.82|P-value:9.64E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:8.62|P-value:4.53E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.55|P-value:3.03E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:7.77|P-value:2.09E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:9.38|P-value:1.02E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:22.90|P-value:1.11E-25 ID:SGTC_1078|Compound:idebenone|FD-Score:8.03|P-value:1.33E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:8.07|P-value:1.25E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-7.30|P-value:4.47E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:7.55|P-value:3.04E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:8.40|P-value:6.86E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.96|P-value:7.90E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-7.08|P-value:6.43E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:11.60|P-value:7.33E-8 ID:SGTC_1478|Compound:0453-0656|FD-Score:7.72|P-value:2.27E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:8.62|P-value:4.52E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:7.35|P-value:4.21E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:9.28|P-value:1.26E-5 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.53|P-value:3.16E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:8.51|P-value:5.56E-5 ID:SGTC_1655|Compound:st012546|FD-Score:8.08|P-value:1.23E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.20|P-value:2.02E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-7.15|P-value:5.76E-4 ID:SGTC_1751|Compound:st044839|FD-Score:8.33|P-value:7.77E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-6.94|P-value:7.96E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-9.15|P-value:1.60E-5 ID:SGTC_1917|Compound:st066507|FD-Score:9.29|P-value:1.23E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-7.31|P-value:4.40E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-7.26|P-value:4.83E-4 ID:SGTC_1953|Compound:st076800|FD-Score:9.95|P-value:3.15E-6 ID:SGTC_1972|Compound:st070201|FD-Score:8.10|P-value:1.19E-4 ID:SGTC_1975|Compound:st070967|FD-Score:11.30|P-value:1.30E-7 ID:SGTC_1991|Compound:st073000|FD-Score:7.45|P-value:3.60E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-8.12|P-value:1.10E-4 ID:SGTC_2013|Compound:4024628|FD-Score:13.10|P-value:1.31E-9 ID:SGTC_2030|Compound:5175110|FD-Score:7.26|P-value:4.94E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-6.86|P-value:9.00E-4 ID:SGTC_2041|Compound:5107442|FD-Score:10.70|P-value:6.56E-7 ID:SGTC_2254|Compound:7938975|FD-Score:11.60|P-value:6.79E-8 ID:SGTC_2255|Compound:7941087|FD-Score:13.60|P-value:3.28E-10 ID:SGTC_2268|Compound:7933382|FD-Score:8.12|P-value:1.14E-4 ID:SGTC_2271|Compound:7849410|FD-Score:7.83|P-value:1.89E-4 ID:SGTC_2277|Compound:7947813|FD-Score:10.70|P-value:6.29E-7 ID:SGTC_2278|Compound:7948257|FD-Score:7.26|P-value:4.93E-4 ID:SGTC_2330|Compound:7979373|FD-Score:13.90|P-value:1.38E-10 ID:SGTC_2332|Compound:7982454|FD-Score:9.41|P-value:9.67E-6 ID:SGTC_2340|Compound:7987427|FD-Score:6.93|P-value:8.34E-4 ID:SGTC_2366|Compound:9070441|FD-Score:9.21|P-value:1.45E-5 ID:SGTC_2399|Compound:5884133|FD-Score:7.22|P-value:5.25E-4 ID:SGTC_2413|Compound:inermin|FD-Score:7.21|P-value:5.32E-4 ID:SGTC_2444|Compound:5485484|FD-Score:7.91|P-value:1.66E-4 ID:SGTC_2460|Compound:5552655|FD-Score:10.60|P-value:7.17E-7 ID:SGTC_2472|Compound:5377652|FD-Score:8.88|P-value:2.76E-5 ID:SGTC_2488|Compound:5268135|FD-Score:10.30|P-value:1.39E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:9.15|P-value:1.63E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:7.48|P-value:3.40E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:9.20|P-value:1.48E-5 ID:SGTC_2695|Compound:st077686|FD-Score:7.73|P-value:2.24E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.70|P-value:6.10E-8 ID:SGTC_2838|Compound:9002687|FD-Score:-7.85|P-value:1.79E-4 ID:SGTC_2873|Compound:9040596|FD-Score:8.71|P-value:3.80E-5 ID:SGTC_2942|Compound:9052777|FD-Score:8.17|P-value:1.05E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-7.51|P-value:3.21E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.78|P-value:2.07E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-7.48|P-value:3.36E-4 ID:SGTC_3098|Compound:9119039|FD-Score:8.89|P-value:2.74E-5 ID:SGTC_3128|Compound:9127691|FD-Score:7.33|P-value:4.35E-4 ID:SGTC_3166|Compound:9102297|FD-Score:8.21|P-value:9.69E-5 ID:SGTC_3189|Compound:9110682|FD-Score:7.53|P-value:3.16E-4 ID:SGTC_3292|Compound:9120825|FD-Score:8.73|P-value:3.68E-5

Top fitness defect scores for YKR019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 31.90 10.3 µM 8.91E-48 NEO1-PIK1 2 4.82E-223
2 SGTC_232 clozapine 23.60 119.0 µM 3.65E-27 NEO1 2 1.13E-123
3 SGTC_1060 3448-7350 22.90 82.0 µM 1.11E-25 Golgi 1 1.53E-116
4 SGTC_56 0957-0365 17.30 83.2 µM 2.15E-15 Golgi 1 3.69E-67
5 SGTC_2330 7979373 13.90 200.0 µM 1.38E-10 60S ribosome export 1 3.28E-44
6 SGTC_2255 7941087 13.60 197.4 µM 3.28E-10 2 2.00E-42
7 SGTC_605 1315-0399 13.40 119.0 µM 5.45E-10 Golgi 1 2.25E-41
8 SGTC_124 0136-0217 13.30 7.1 µM 8.10E-10 mitochondrial stress 3 1.48E-40
9 SGTC_2013 4024628 13.10 200.0 µM 1.31E-9 1 1.44E-39
10 SGTC_2752 diclazuril 11.70 33.1 µM 6.10E-8 15 1.15E-31
11 SGTC_2254 7938975 11.60 95.2 µM 6.79E-8 10 1.91E-31
12 SGTC_1313 1220-0047 11.60 237.0 µM 7.33E-8 2 2.73E-31
13 SGTC_1975 st070967 11.30 30.8 µM 1.30E-7 4 4.06E-30
14 SGTC_717 1532-0246 11.20 73.2 µM 1.64E-7 Golgi 1 1.23E-29
15 SGTC_2277 7947813 10.70 106.9 µM 6.29E-7 RSC complex & mRNA processing 1 6.84E-27
16 SGTC_2041 5107442 10.70 45.3 µM 6.56E-7 RSC complex & mRNA processing 1 8.33E-27
17 SGTC_2460 5552655 10.60 174.2 µM 7.17E-7 amide catabolism 3 1.27E-26
18 SGTC_2488 5268135 10.30 45.7 µM 1.39E-6 9 2.81E-25
19 SGTC_1679 4130-1276 10.20 6.7 µM 2.02E-6 Golgi 11 1.64E-24
20 SGTC_119 0121-0043 10.00 24.8 µM 2.70E-6 mitochondrial stress 6 6.39E-24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.453 1.03E-168 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.446 9.99E-163 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.439 7.12E-157 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.396 4.06E-126 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.329 3.86E-85 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.307 1.00E-73 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.298 3.09E-69 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.289 1.54E-65 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.288 6.92E-65 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.279 7.56E-61 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.266 5.04E-55 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.243 4.30E-46 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.227 1.88E-40 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.218 1.92E-37 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.206 1.93E-33 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion