YKR022C / NTR2

Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR022C / NTR2

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-6.54|P-value:1.45E-11 ID:SGTC_306|Compound:1672-3436|FD-Score:4.63|P-value:1.21E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.09|P-value:8.24E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.65|P-value:1.04E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.16|P-value:6.60E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.38|P-value:4.17E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.40|P-value:2.69E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.09|P-value:8.26E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.88|P-value:3.95E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.72|P-value:7.66E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.15|P-value:6.65E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.15|P-value:6.70E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.98|P-value:2.57E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.15|P-value:6.82E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.33|P-value:5.25E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.55|P-value:1.50E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.33|P-value:3.52E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.30|P-value:6.02E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-6.54|P-value:1.45E-11 ID:SGTC_306|Compound:1672-3436|FD-Score:4.63|P-value:1.21E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.09|P-value:8.24E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.65|P-value:1.04E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.16|P-value:6.60E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.38|P-value:4.17E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:3.40|P-value:2.69E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.05|P-value:9.55E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.09|P-value:8.26E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.88|P-value:3.95E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.72|P-value:7.66E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.15|P-value:6.65E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.48|P-value:2.02E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.15|P-value:6.70E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.98|P-value:2.57E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.15|P-value:6.82E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.33|P-value:5.25E-6 ID:SGTC_2804|Compound:7954240|FD-Score:3.55|P-value:1.50E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.43|P-value:2.41E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.33|P-value:3.52E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.30|P-value:6.02E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.57|P-value:1.40E-4

Top fitness defect scores for YKR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_306 1672-3436 4.63 11.6 µM 1.21E-6 Golgi 1 1.79E-6 0.43
2 SGTC_725 1497-0963 4.38 19.0 µM 4.17E-6 copper-dependent oxidative stress 2 5.90E-6 0.71
3 SGTC_2800 7887935 4.33 81.8 µM 5.25E-6 RPP1 & pyrimidine depletion 7 7.38E-6 0.06
4 SGTC_2992 9074591 4.30 71.4 µM 6.02E-6 3 8.42E-6 0.17
5 SGTC_2307 7538926 3.98 6.3 µM 2.57E-5 22 3.43E-5 0.04
6 SGTC_1759 st043059 3.88 70.0 µM 3.95E-5 amide catabolism 5 5.21E-5 0.06
7 SGTC_1964 st076914 3.72 61.0 µM 7.66E-5 RPP1 & pyrimidine depletion 10 9.89E-5 0.15
8 SGTC_612 0302-0167 3.58 22.4 µM 1.36E-4 copper-dependent oxidative stress 9 1.72E-4 0.04
9 SGTC_3088 9117578 3.57 49.5 µM 1.40E-4 amide catabolism 3 1.78E-4 0.00
10 SGTC_2804 7954240 3.55 19.5 µM 1.50E-4 15 1.89E-4 0.06
11 SGTC_2028 5153890 3.48 36.4 µM 2.02E-4 cell wall signaling 13 2.52E-4 0.06
12 SGTC_2904 7225135 3.43 42.0 µM 2.41E-4 3 3.00E-4 0.08
13 SGTC_726 3448-4391 3.40 34.2 µM 2.69E-4 6 3.34E-4 0.18
14 SGTC_1831 st055328 3.35 12.0 µM 3.28E-4 heme biosynthesis & mitochondrial translocase 20 4.05E-4 0.02
15 SGTC_2984 9022109 3.33 39.0 µM 3.52E-4 8 4.33E-4 0.10
16 SGTC_1883 5-benzylidenerhodanine 3.29 20.0 µM 4.05E-4 TRP & mitochondrial translation 10 4.96E-4 0.03
17 SGTC_2956 9076196 3.24 2.5 µM 4.99E-4 8 6.07E-4 0.02
18 SGTC_1990 st072050 3.15 59.8 µM 6.65E-4 7 8.03E-4 0.05
19 SGTC_2098 5376439 3.15 882.5 nM 6.70E-4 11 8.08E-4 0.02
20 SGTC_1949 st076024 3.14 69.1 µM 6.92E-4 15 8.34E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.19E-11 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.109 2.42E-10 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.107 5.99E-10 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.105 1.08E-9 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.085 7.77E-7 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.085 8.02E-7 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.083 1.60E-6 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.082 2.06E-6 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.082 2.16E-6 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.080 3.37E-6 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.080 3.92E-6 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.080 3.85E-6 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.080 3.95E-6 YOR247W SRL1 hom Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication
0.078 5.71E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.078 5.79E-6 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p