YKR024C / DBP7

Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR024C / DBP7

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.82|P-value:5.56E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:2.80E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.87|P-value:4.59E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.90|P-value:1.19E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.11|P-value:1.17E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:8.51|P-value:3.35E-18 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.46|P-value:1.61E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.09|P-value:9.08E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.79|P-value:5.46E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:4.71|P-value:9.54E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.68|P-value:9.79E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.85|P-value:4.60E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:8.14|P-value:7.85E-17 ID:SGTC_543|Compound:3844-1095|FD-Score:4.90|P-value:3.49E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.13|P-value:6.90E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:4.94|P-value:2.91E-7 ID:SGTC_662|Compound:k832-1615|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.32|P-value:6.14E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.08|P-value:9.20E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.15|P-value:1.14E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.16|P-value:6.97E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.13|P-value:7.11E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:5.26|P-value:5.11E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:3.72|P-value:8.35E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:5.42|P-value:2.05E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:3.53|P-value:1.78E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.18|P-value:1.15E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.17|P-value:6.76E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:6.22|P-value:1.50E-10 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.82|P-value:5.56E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.13|P-value:7.74E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.26|P-value:4.89E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.07|P-value:1.94E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.38|P-value:4.80E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.23|P-value:5.55E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.24|P-value:9.18E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.60|P-value:1.59E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.74|P-value:7.95E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:2.76E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.10|P-value:1.49E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:6.09E-14 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.58|P-value:1.56E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.28|P-value:4.55E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.20|P-value:5.44E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.91|P-value:3.40E-7 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.13|P-value:6.92E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-3.26|P-value:4.34E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:2.38E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.53|P-value:1.84E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.33|P-value:3.43E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.34|P-value:3.68E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.15|P-value:1.37E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.96|P-value:2.62E-7 ID:SGTC_2099|Compound:5377090|FD-Score:5.56|P-value:8.93E-9 ID:SGTC_2100|Compound:5377183|FD-Score:-4.16|P-value:1.13E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.30|P-value:3.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.80|P-value:6.14E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.18|P-value:5.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.41|P-value:2.53E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.72|P-value:8.60E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.76|P-value:7.46E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-3.07|P-value:8.50E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.28|P-value:4.54E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.94|P-value:3.37E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.70|P-value:9.24E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.53|P-value:1.56E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:6.99E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.48|P-value:1.89E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.93|P-value:3.08E-5 ID:SGTC_3122|Compound:9126309|FD-Score:3.35|P-value:3.58E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.54|P-value:1.55E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.17|P-value:6.83E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.79|P-value:5.55E-5 ID:SGTC_33|Compound:0986-0033|FD-Score:3.82|P-value:5.56E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:2.80E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:1.08E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.87|P-value:4.59E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:5.90|P-value:1.19E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.11|P-value:1.17E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:8.51|P-value:3.35E-18 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.46|P-value:1.61E-8 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.09|P-value:9.08E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.79|P-value:5.46E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:4.71|P-value:9.54E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.68|P-value:9.79E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.85|P-value:4.60E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:8.14|P-value:7.85E-17 ID:SGTC_543|Compound:3844-1095|FD-Score:4.90|P-value:3.49E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.13|P-value:6.90E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:4.94|P-value:2.91E-7 ID:SGTC_662|Compound:k832-1615|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.32|P-value:6.14E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:3.08|P-value:9.20E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.15|P-value:1.14E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.16|P-value:6.97E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.13|P-value:7.11E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:5.26|P-value:5.11E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:3.72|P-value:8.35E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:5.42|P-value:2.05E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:3.53|P-value:1.78E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.18|P-value:1.15E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.17|P-value:6.76E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:6.22|P-value:1.50E-10 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.82|P-value:5.56E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.13|P-value:7.74E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.26|P-value:4.89E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.07|P-value:1.94E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.38|P-value:4.80E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.23|P-value:5.55E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:4.24|P-value:9.18E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.60|P-value:1.59E-6 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.74|P-value:7.95E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.99|P-value:2.76E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.55|P-value:1.69E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.10|P-value:1.49E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.32|P-value:6.09E-14 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.58|P-value:1.56E-6 ID:SGTC_1571|Compound:st070080|FD-Score:3.28|P-value:4.55E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.20|P-value:5.44E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.09|P-value:9.12E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.91|P-value:3.40E-7 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.13|P-value:6.92E-4 ID:SGTC_1976|Compound:st070609|FD-Score:-3.26|P-value:4.34E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:2.38E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.53|P-value:1.84E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.33|P-value:3.43E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.34|P-value:3.68E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.15|P-value:1.37E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.96|P-value:2.62E-7 ID:SGTC_2099|Compound:5377090|FD-Score:5.56|P-value:8.93E-9 ID:SGTC_2100|Compound:5377183|FD-Score:-4.16|P-value:1.13E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.30|P-value:3.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.80|P-value:6.14E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.18|P-value:5.94E-4 ID:SGTC_2348|Compound:9022543|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.41|P-value:2.53E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.72|P-value:8.60E-5 ID:SGTC_2479|Compound:5617353|FD-Score:4.76|P-value:7.46E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-3.07|P-value:8.50E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.28|P-value:4.54E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.94|P-value:3.37E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.70|P-value:9.24E-5 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.53|P-value:1.56E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:6.99E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.48|P-value:1.89E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.93|P-value:3.08E-5 ID:SGTC_3122|Compound:9126309|FD-Score:3.35|P-value:3.58E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.54|P-value:1.55E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.17|P-value:6.83E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.79|P-value:5.55E-5

Top fitness defect scores for YKR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_241 5hr heat shock (37°C) + cantharidin 8.51 155.4 µM 3.35E-18 cell wall signaling 15 9.05E-18
2 SGTC_536 3852-0578 8.14 10.6 µM 7.85E-17 1 1.94E-16
3 SGTC_1495 4469-0029 7.32 237.0 µM 6.09E-14 33 1.25E-13
4 SGTC_1070 indatraline 6.22 8.8 µM 1.50E-10 60S ribosome export 5 2.49E-10
5 SGTC_239 5hr heat shock (37°C) + mitomycin C 5.90 819.4 µM 1.19E-9 heat shock/prefoldin 12 1.87E-9
6 SGTC_2099 5377090 5.56 177.4 µM 8.93E-9 5 1.33E-8
7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.46 4.6 µM 1.61E-8 heat shock/prefoldin 18 2.36E-8
8 SGTC_937 3122-0005 5.42 46.7 µM 2.05E-8 9 2.99E-8
9 SGTC_914 3820-6779 5.26 408.0 µM 5.11E-8 5 7.27E-8
10 SGTC_240 5hr heat shock (37°C) + Streptovitacin 5.11 300.0 µM 1.17E-7 heat shock/prefoldin 24 1.63E-7
11 SGTC_2094 5332512 4.96 191.7 µM 2.62E-7 10 3.58E-7
12 SGTC_620 0109-0052 4.94 432.0 µM 2.91E-7 6 3.95E-7
13 SGTC_1920 st075728 4.91 45.7 µM 3.40E-7 5 4.61E-7
14 SGTC_543 3844-1095 4.90 191.0 µM 3.49E-7 ERG2 31 4.73E-7
15 SGTC_531 3788-1495 4.85 174.0 µM 4.60E-7 unfolded protein response 11 6.18E-7
16 SGTC_2479 5617353 4.76 43.9 µM 7.46E-7 16 9.89E-7
17 SGTC_404 fumagillin 4.71 50.0 µM 9.54E-7 8 1.26E-6
18 SGTC_1171 0368-0077 4.60 21.4 µM 1.59E-6 13 2.07E-6
19 SGTC_1123 mangostin 4.38 811.3 nM 4.80E-6 mitochondrial response to ROS 27 6.07E-6
20 SGTC_668 1682-0499 4.32 62.6 µM 6.14E-6 16 7.71E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 7.33E-34 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.165 7.15E-22 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.159 2.25E-20 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.153 5.31E-19 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.152 8.77E-19 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.134 8.64E-15 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.113 5.41E-11 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.113 6.33E-11 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.112 9.61E-11 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.108 3.77E-10 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.107 4.98E-10 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.107 5.32E-10 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.107 5.48E-10 YBR188C NTC20 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.103 2.03E-9 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.101 5.53E-9 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress