YKR025W / RPC37

RNA polymerase III subunit C37

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR025W / RPC37

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.91|P-value:1.63E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.18|P-value:4.05E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.85|P-value:1.36E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.04|P-value:6.08E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:4.35E-30 ID:SGTC_324|Compound:1315-0088|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.11|P-value:6.36E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:2.92|P-value:9.73E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.01|P-value:7.68E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.76|P-value:3.64E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.11|P-value:4.81E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.45|P-value:1.36E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.27|P-value:2.54E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.85|P-value:1.30E-7 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.05|P-value:9.52E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.23|P-value:3.30E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.19|P-value:3.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-5.92|P-value:2.09E-10 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.27|P-value:2.57E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.59|P-value:7.05E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.99|P-value:8.27E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:1.48E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.54|P-value:8.67E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.10|P-value:4.89E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.02|P-value:5.14E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.11|P-value:4.70E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.72|P-value:2.77E-7 ID:SGTC_1820|Compound:st053765|FD-Score:-3.54|P-value:9.57E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.50|P-value:9.03E-7 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.50|P-value:9.95E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.76|P-value:3.33E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.00|P-value:7.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-5.73|P-value:7.21E-10 ID:SGTC_2349|Compound:9023730|FD-Score:-3.65|P-value:6.00E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.02|P-value:1.09E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.92|P-value:9.45E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.24|P-value:1.41E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.90|P-value:1.71E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.47|P-value:1.27E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.21|P-value:3.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.45|P-value:1.23E-4 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.16|P-value:4.99E-6 ID:SGTC_3156|Compound:9099931|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.41|P-value:1.62E-6 ID:SGTC_3230|Compound:9131665|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_3257|Compound:9139206|FD-Score:2.95|P-value:8.63E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.12|P-value:4.63E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.06|P-value:4.10E-8 ID:SGTC_3345|Compound:9148410|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.91|P-value:1.63E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.18|P-value:4.05E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.85|P-value:1.36E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.04|P-value:6.08E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.70|P-value:4.35E-30 ID:SGTC_324|Compound:1315-0088|FD-Score:2.92|P-value:9.75E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.11|P-value:6.36E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:2.92|P-value:9.73E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.01|P-value:7.68E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.76|P-value:3.64E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.11|P-value:4.81E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.45|P-value:1.36E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.27|P-value:2.54E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.85|P-value:1.30E-7 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.05|P-value:9.52E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.23|P-value:3.30E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.19|P-value:3.49E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-5.92|P-value:2.09E-10 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.27|P-value:2.57E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.59|P-value:7.05E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.99|P-value:8.27E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:1.48E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.54|P-value:8.67E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.10|P-value:4.89E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.02|P-value:5.14E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.11|P-value:4.70E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.72|P-value:2.77E-7 ID:SGTC_1820|Compound:st053765|FD-Score:-3.54|P-value:9.57E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.50|P-value:9.03E-7 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.50|P-value:9.95E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.76|P-value:3.33E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.00|P-value:7.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-5.73|P-value:7.21E-10 ID:SGTC_2349|Compound:9023730|FD-Score:-3.65|P-value:6.00E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.02|P-value:1.09E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.92|P-value:9.45E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.24|P-value:1.41E-8 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.90|P-value:1.71E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.47|P-value:1.27E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.21|P-value:3.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.45|P-value:1.23E-4 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.16|P-value:4.99E-6 ID:SGTC_3156|Compound:9099931|FD-Score:3.18|P-value:3.61E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-4.41|P-value:1.62E-6 ID:SGTC_3230|Compound:9131665|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_3257|Compound:9139206|FD-Score:2.95|P-value:8.63E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.12|P-value:4.63E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.06|P-value:4.10E-8 ID:SGTC_3345|Compound:9148410|FD-Score:3.01|P-value:6.82E-4

Top fitness defect scores for YKR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_236 1509-0011 10.70 5.3 µM 4.35E-30 2 5.06E-27 1.76
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.24 3.7 µM 1.41E-8 3 8.24E-8 0.31
3 SGTC_3340 9146634 5.06 11.1 µM 4.10E-8 2 2.14E-7 1.35
4 SGTC_1643 st009866 5.02 20.2 µM 5.14E-8 15 2.62E-7 0.19
5 SGTC_664 1222-0054 4.85 14.9 µM 1.30E-7 sphingolipid biosynthesis & PDR1 6 6.03E-7 0.21
6 SGTC_81 0411-0046 4.85 10.0 µM 1.36E-7 29 6.26E-7 0.17
7 SGTC_1805 st050013 4.72 60.3 µM 2.77E-7 1 1.18E-6 1.12
8 SGTC_2026 5148700 4.50 152.0 µM 9.03E-7 3 3.41E-6 0.14
9 SGTC_3154 9100113 4.16 49.5 µM 4.99E-6 10 1.57E-5 0.12
10 SGTC_344 k064-0035 4.11 6.4 µM 6.36E-6 60S ribosome export 6 1.95E-5 0.18
11 SGTC_6 0844-0013 3.91 19.8 µM 1.63E-5 6 4.54E-5 0.01
12 SGTC_2596 sinensetin 3.90 100.0 µM 1.71E-5 5 4.73E-5 0.21
13 SGTC_2159 5658611 3.76 73.8 µM 3.33E-5 8 8.62E-5 0.01
14 SGTC_1215 3852-0577 3.59 11.2 µM 7.05E-5 7 1.68E-4 0.01
15 SGTC_1619 st003326 3.54 88.7 µM 8.67E-5 60S ribosome export 7 2.03E-4 0.06
16 SGTC_2039 Aminomethylbenzodioxan 3.50 200.0 µM 9.95E-5 3 2.29E-4 0.14
17 SGTC_3141 9094609 3.45 49.5 µM 1.23E-4 iron homeostasis 20 2.77E-4 0.03
18 SGTC_905 2-aminofluorene 3.43 215.0 µM 1.34E-4 cell wall signaling 8 3.00E-4 0.03
19 SGTC_114 0364-0001 3.41 490.3 µM 1.47E-4 12 3.25E-4 0.03
20 SGTC_1233 0325-0408 3.41 14.2 µM 1.48E-4 11 3.28E-4 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.298 9.47E-70 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.293 1.84E-67 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.290 5.25E-66 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.276 6.59E-60 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.275 2.89E-59 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.262 1.46E-53 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.261 2.33E-53 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.260 3.83E-53 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.257 6.30E-52 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.256 1.98E-51 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.252 1.62E-49 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.245 5.47E-47 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.242 5.08E-46 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.238 1.98E-44 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.238 2.96E-44 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex