HIPHOP chemogenomics database

YKR025W / RPC37

RNA polymerase III subunit C37

Zygosity: Heterozygous strain

fixedexpanded
Profile for YKR025W / RPC37

Click on Significant Values for Screen Details

Top fitness defect scores for YKR025W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_236	1509-0011	10.70	5.3 µM	4.35E-30		2	5.06E-27	1.76
2	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	5.24	3.7 µM	1.41E-8		3	8.24E-8	0.31
3	SGTC_3340	9146634	5.06	11.1 µM	4.10E-8		2	2.14E-7	1.35
4	SGTC_1643	st009866	5.02	20.2 µM	5.14E-8		15	2.62E-7	0.19
5	SGTC_664	1222-0054	4.85	14.9 µM	1.30E-7	sphingolipid biosynthesis & PDR1	6	6.03E-7	0.21
6	SGTC_81	0411-0046	4.85	10.0 µM	1.36E-7		29	6.26E-7	0.17
7	SGTC_1805	st050013	4.72	60.3 µM	2.77E-7		1	1.18E-6	1.12
8	SGTC_2026	5148700	4.50	152.0 µM	9.03E-7		3	3.41E-6	0.14
9	SGTC_3154	9100113	4.16	49.5 µM	4.99E-6		10	1.57E-5	0.12
10	SGTC_344	k064-0035	4.11	6.4 µM	6.36E-6	60S ribosome export	6	1.95E-5	0.18
11	SGTC_6	0844-0013	3.91	19.8 µM	1.63E-5		6	4.54E-5	0.01
12	SGTC_2596	sinensetin	3.90	100.0 µM	1.71E-5		5	4.73E-5	0.21
13	SGTC_2159	5658611	3.76	73.8 µM	3.33E-5		8	8.62E-5	0.01
14	SGTC_1215	3852-0577	3.59	11.2 µM	7.05E-5		7	1.68E-4	0.01
15	SGTC_1619	st003326	3.54	88.7 µM	8.67E-5	60S ribosome export	7	2.03E-4	0.06
16	SGTC_2039	Aminomethylbenzodioxan	3.50	200.0 µM	9.95E-5		3	2.29E-4	0.14
17	SGTC_3141	9094609	3.45	49.5 µM	1.23E-4	iron homeostasis	20	2.77E-4	0.03
18	SGTC_905	2-aminofluorene	3.43	215.0 µM	1.34E-4	cell wall signaling	8	3.00E-4	0.03
19	SGTC_114	0364-0001	3.41	490.3 µM	1.47E-4		12	3.25E-4	0.03
20	SGTC_1233	0325-0408	3.41	14.2 µM	1.48E-4		11	3.28E-4	0.18

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.298	9.47E-70	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.293	1.84E-67	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.290	5.25E-66	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.276	6.59E-60	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.275	2.89E-59	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.262	1.46E-53	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.261	2.33E-53	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.260	3.83E-53	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.257	6.30E-52	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.256	1.98E-51	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.252	1.62E-49	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit
0.245	5.47E-47	YGL107C	RMD9	hom	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.242	5.08E-46	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.238	1.98E-44	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.238	2.96E-44	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex