Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.298 |
9.47E-70 |
YJR120W |
YJR120W |
hom |
Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p |
0.293 |
1.84E-67 |
YGL237C |
HAP2 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding |
0.290 |
5.25E-66 |
YHR050W-A_p |
YHR050W-A_p |
hom |
Protein of unknown function; identified by expression profiling and mass spectrometry |
0.276 |
6.59E-60 |
YMR035W |
IMP2 |
hom |
Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
0.275 |
2.89E-59 |
YOR330C |
MIP1 |
hom |
Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit |
0.262 |
1.46E-53 |
YKL109W |
HAP4 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex |
0.261 |
2.33E-53 |
YJL166W |
QCR8 |
hom |
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
0.260 |
3.83E-53 |
YJL023C |
PET130 |
hom |
Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.257 |
6.30E-52 |
YKL087C |
CYT2 |
hom |
Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 |
0.256 |
1.98E-51 |
YDR230W_d |
YDR230W_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 |
0.252 |
1.62E-49 |
YMR286W |
MRPL33 |
hom |
Mitochondrial ribosomal protein of the large subunit |
0.245 |
5.47E-47 |
YGL107C |
RMD9 |
hom |
Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes |
0.242 |
5.08E-46 |
YER141W |
COX15 |
hom |
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
0.238 |
1.98E-44 |
YPL215W |
CBP3 |
hom |
Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
0.238 |
2.96E-44 |
YOR065W |
CYT1 |
hom |
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex |