YKR027W / BCH2

Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR027W / BCH2

Click on Significant Values for Screen Details ID:SGTC_185|Compound:k048-0037|FD-Score:4.24|P-value:1.15E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.24|P-value:5.94E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.10|P-value:9.71E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.58|P-value:1.77E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.39|P-value:3.56E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.63|P-value:1.89E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-3.38|P-value:3.49E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.19|P-value:7.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.23|P-value:6.27E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.53|P-value:2.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.53|P-value:2.07E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.86|P-value:5.45E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.59|P-value:2.11E-6 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.15|P-value:8.02E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.30|P-value:8.59E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.20|P-value:7.06E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.16|P-value:1.59E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.80|P-value:7.41E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.48|P-value:2.54E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.41|P-value:5.23E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.52|P-value:3.13E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.11|P-value:9.62E-4 ID:SGTC_2064|Compound:5220758|FD-Score:7.02|P-value:1.13E-12 ID:SGTC_2065|Compound:5221596|FD-Score:-3.25|P-value:5.69E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.42|P-value:4.70E-6 ID:SGTC_2082|Compound:5219693|FD-Score:5.42|P-value:3.08E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.78|P-value:8.11E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.41|P-value:5.24E-6 ID:SGTC_2431|Compound:5490079|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.13|P-value:1.85E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:1.98E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.02|P-value:2.95E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.80|P-value:8.16E-7 ID:SGTC_2691|Compound:st077356|FD-Score:6.25|P-value:2.07E-10 ID:SGTC_2692|Compound:st077426|FD-Score:-3.49|P-value:2.40E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.29|P-value:6.18E-8 ID:SGTC_2844|Compound:9010103|FD-Score:-4.07|P-value:2.32E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.62|P-value:1.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.13|P-value:8.80E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.55|P-value:1.88E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.63|P-value:9.18E-9 ID:SGTC_3133|Compound:9127736|FD-Score:-3.19|P-value:7.01E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.88|P-value:5.24E-7 ID:SGTC_3221|Compound:9128209|FD-Score:3.10|P-value:9.81E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:4.24|P-value:1.15E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:-3.24|P-value:5.94E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.10|P-value:9.71E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.58|P-value:1.77E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.39|P-value:3.56E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.63|P-value:1.89E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-3.38|P-value:3.49E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.19|P-value:7.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.23|P-value:6.27E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.53|P-value:2.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.53|P-value:2.07E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.86|P-value:5.45E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.59|P-value:2.11E-6 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.15|P-value:8.02E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.30|P-value:8.59E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.20|P-value:7.06E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.59|P-value:1.62E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.13|P-value:8.79E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.16|P-value:1.59E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.80|P-value:7.41E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.48|P-value:2.54E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.41|P-value:5.23E-6 ID:SGTC_1891|Compound:st059073|FD-Score:4.52|P-value:3.13E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.11|P-value:9.62E-4 ID:SGTC_2064|Compound:5220758|FD-Score:7.02|P-value:1.13E-12 ID:SGTC_2065|Compound:5221596|FD-Score:-3.25|P-value:5.69E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-4.42|P-value:4.70E-6 ID:SGTC_2082|Compound:5219693|FD-Score:5.42|P-value:3.08E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.17|P-value:7.68E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.78|P-value:8.11E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.41|P-value:5.24E-6 ID:SGTC_2431|Compound:5490079|FD-Score:3.36|P-value:3.92E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.13|P-value:1.85E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.54|P-value:1.98E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.02|P-value:2.95E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.80|P-value:8.16E-7 ID:SGTC_2691|Compound:st077356|FD-Score:6.25|P-value:2.07E-10 ID:SGTC_2692|Compound:st077426|FD-Score:-3.49|P-value:2.40E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.29|P-value:6.18E-8 ID:SGTC_2844|Compound:9010103|FD-Score:-4.07|P-value:2.32E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.62|P-value:1.52E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.13|P-value:8.80E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.55|P-value:1.88E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.63|P-value:9.18E-9 ID:SGTC_3133|Compound:9127736|FD-Score:-3.19|P-value:7.01E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.88|P-value:5.24E-7 ID:SGTC_3221|Compound:9128209|FD-Score:3.10|P-value:9.81E-4

Top fitness defect scores for YKR027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2064 5220758 7.02 200.0 µM 1.13E-12 5 1.11E-12
2 SGTC_2691 st077356 6.25 60.2 µM 2.07E-10 4 2.03E-10
3 SGTC_3020 9089140 5.63 49.5 µM 9.18E-9 5 9.00E-9
4 SGTC_2082 5219693 5.42 150.0 µM 3.08E-8 RNA processing & uracil transport 5 3.02E-8
5 SGTC_2753 fluvastatin 5.29 17.1 µM 6.18E-8 azole & statin 10 6.07E-8
6 SGTC_2687 chenodiol 4.80 100.0 µM 8.16E-7 10 8.01E-7
7 SGTC_473 2-arachidonoylglycerol 4.63 10.0 µM 1.89E-6 11 1.86E-6
8 SGTC_1891 st059073 4.52 26.2 µM 3.13E-6 TSC3-RPN4 11 3.07E-6
9 SGTC_1871 st057448 4.41 67.3 µM 5.23E-6 15 5.14E-6
10 SGTC_2322 7413319 4.41 38.2 µM 5.24E-6 ERAD & cell cycle 130 5.15E-6
11 SGTC_1454 4239-0054 4.30 42.6 µM 8.59E-6 24 8.44E-6
12 SGTC_185 k048-0037 4.24 25.5 µM 1.15E-5 RSC & ERG11 8 1.13E-5
13 SGTC_1739 st037196 4.16 92.5 µM 1.59E-5 15 1.57E-5
14 SGTC_2481 5478948 4.13 45.2 µM 1.85E-5 PDR1 32 1.82E-5
15 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.02 70.0 µM 2.95E-5 redox potentiating 70 2.90E-5
16 SGTC_1742 st038235 3.80 28.9 µM 7.41E-5 mitochondrial stress 121 7.30E-5
17 SGTC_2274 7947094 3.78 46.1 µM 8.11E-5 41 7.99E-5
18 SGTC_532 1548-0774 3.72 215.0 µM 1.01E-4 25 9.96E-5
19 SGTC_1731 st035964 3.66 63.0 µM 1.27E-4 41 1.25E-4
20 SGTC_2873 9040596 3.62 71.4 µM 1.52E-4 61 1.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.28E-16 YJR057W CDC8 het Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
0.120 3.18E-12 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.110 1.65E-10 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.106 8.38E-10 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.090 1.98E-7 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.090 2.06E-7 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.088 3.77E-7 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.087 4.04E-7 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.087 4.73E-7 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.086 6.37E-7 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.083 1.64E-6 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.081 2.96E-6 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.080 3.40E-6 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.080 3.50E-6 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.080 3.82E-6 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc