YKR028W / SAP190

Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR028W / SAP190

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:8.73|P-value:1.20E-18 ID:SGTC_37|Compound:0566-0070|FD-Score:7.66|P-value:9.10E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:4.93|P-value:4.03E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:4.18|P-value:1.40E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.54|P-value:1.45E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:4.31E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.05|P-value:2.51E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.97|P-value:3.22E-7 ID:SGTC_827|Compound:3253-0474|FD-Score:3.09|P-value:9.94E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.35|P-value:1.05E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.17|P-value:1.17E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.14|P-value:8.48E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.40|P-value:3.30E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.30|P-value:1.39E-13 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.28|P-value:9.12E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-4.30|P-value:8.47E-6 ID:SGTC_2416|Compound:tofa|FD-Score:33.30|P-value:1.74E-243 ID:SGTC_2451|Compound:5856223|FD-Score:3.33|P-value:4.23E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.08|P-value:2.18E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.35|P-value:6.72E-6 ID:SGTC_2691|Compound:st077356|FD-Score:-4.31|P-value:8.20E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.84|P-value:6.25E-7 ID:SGTC_3015|Compound:9080845|FD-Score:3.13|P-value:8.54E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.73|P-value:1.20E-18 ID:SGTC_37|Compound:0566-0070|FD-Score:7.66|P-value:9.10E-15 ID:SGTC_58|Compound:0957-0393|FD-Score:4.93|P-value:4.03E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:4.18|P-value:1.40E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.54|P-value:1.45E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:4.31E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.05|P-value:2.51E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.97|P-value:3.22E-7 ID:SGTC_827|Compound:3253-0474|FD-Score:3.09|P-value:9.94E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.35|P-value:1.05E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.17|P-value:1.17E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.14|P-value:8.48E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.40|P-value:3.30E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.30|P-value:1.39E-13 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.28|P-value:9.12E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-4.30|P-value:8.47E-6 ID:SGTC_2416|Compound:tofa|FD-Score:33.30|P-value:1.74E-243 ID:SGTC_2451|Compound:5856223|FD-Score:3.33|P-value:4.23E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.08|P-value:2.18E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.35|P-value:6.72E-6 ID:SGTC_2691|Compound:st077356|FD-Score:-4.31|P-value:8.20E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.42|P-value:3.08E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.84|P-value:6.25E-7 ID:SGTC_3015|Compound:9080845|FD-Score:3.13|P-value:8.54E-4

Top fitness defect scores for YKR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2416 tofa 33.30 880.0 nM 1.74E-243 sphingolipid biosynthesis & PDR1 1 4.75E-243
2 SGTC_36 0335-0881 8.73 14.2 µM 1.20E-18 ubiquinone biosynthesis & proteasome 28 1.30E-18
3 SGTC_37 0566-0070 7.66 1.6 µM 9.10E-15 4 9.65E-15
4 SGTC_2248 tofa 7.30 1.1 µM 1.39E-13 sphingolipid biosynthesis & PDR1 12 1.47E-13
5 SGTC_453 enantio-paf c16 5.54 10.0 µM 1.45E-8 67 1.49E-8
6 SGTC_767 0929-0023 4.97 86.0 µM 3.22E-7 TRP & mitochondrial translation 39 3.31E-7
7 SGTC_58 0957-0393 4.93 9.0 µM 4.03E-7 cell wall 291 4.14E-7
8 SGTC_2998 9066762 4.84 71.4 µM 6.25E-7 RPP1 & pyrimidine depletion 9 6.42E-7
9 SGTC_363 0455-0021 4.18 3.1 µM 1.40E-5 azole & statin 58 1.43E-5
10 SGTC_2635 hydroquinidine 4.08 100.0 µM 2.18E-5 22 2.22E-5
11 SGTC_628 1636-0253 4.05 16.0 µM 2.51E-5 sphingolipid biosynthesis & PDR1 31 2.56E-5
12 SGTC_1114 scopoletin 3.64 1.7 µM 1.33E-4 24 1.35E-4
13 SGTC_636 0kpi-0074 3.57 126.0 µM 1.78E-4 29 1.80E-4
14 SGTC_942 3253-1115 3.47 227.0 µM 2.57E-4 48 2.60E-4
15 SGTC_2911 7942208 3.42 15.6 µM 3.08E-4 mitochondrial response to ROS 26 3.13E-4
16 SGTC_1228 0124-0032 3.40 52.5 µM 3.30E-4 32 3.35E-4
17 SGTC_2049 5262831 3.37 67.2 µM 3.70E-4 53 3.75E-4
18 SGTC_2451 5856223 3.33 45.7 µM 4.23E-4 35 4.29E-4
19 SGTC_513 4245-1575 3.33 41.7 µM 4.31E-4 unfolded protein response 159 4.37E-4
20 SGTC_637 1181-0519 3.30 7.3 µM 4.78E-4 fatty acid desaturase (OLE1) 138 4.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.345 2.45E-94 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.316 8.34E-79 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.303 6.17E-72 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.291 2.57E-66 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.242 8.51E-46 YEL062W NPR2 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
0.209 2.49E-34 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.207 1.17E-33 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.200 1.28E-31 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.196 1.80E-30 YKL085W MDH1 hom Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
0.184 6.21E-27 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.175 1.82E-24 YDR011W SNQ2 hom Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
0.172 9.85E-24 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.166 3.22E-22 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.160 8.68E-21 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
0.160 1.31E-20 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress