YKR030W / GMH1

Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR030W / GMH1

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:3.13|P-value:3.04E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.77|P-value:7.87E-8 ID:SGTC_182|Compound:3448-4371|FD-Score:7.81|P-value:5.10E-18 ID:SGTC_183|Compound:3914-0051|FD-Score:7.18|P-value:1.76E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:3.90|P-value:9.66E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.78|P-value:1.75E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.15|P-value:2.63E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.10|P-value:3.27E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.95|P-value:6.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.14|P-value:2.83E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.79|P-value:1.60E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.60|P-value:3.94E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:2.99|P-value:5.31E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.97|P-value:5.52E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:8.37E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.08|P-value:3.73E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.57|P-value:4.40E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:4.88|P-value:4.36E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.17|P-value:2.31E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:3.04|P-value:4.34E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.11|P-value:3.27E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.91|P-value:7.18E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.01|P-value:4.95E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.82|P-value:1.37E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.27|P-value:1.40E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.63|P-value:3.43E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.95|P-value:6.15E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:2.63E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.98|P-value:6.44E-6 ID:SGTC_1716|Compound:st033144|FD-Score:2.95|P-value:6.16E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.09|P-value:3.71E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.87|P-value:1.09E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.58|P-value:4.43E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-2.89|P-value:7.34E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.69|P-value:2.56E-5 ID:SGTC_2314|Compound:7727897|FD-Score:2.98|P-value:5.43E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.61|P-value:3.90E-10 ID:SGTC_2473|Compound:5854593|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.05|P-value:4.18E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.17|P-value:2.46E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:2.87|P-value:8.34E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.12|P-value:3.13E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:5.95E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-2.98|P-value:5.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.10|P-value:3.25E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.03|P-value:4.51E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.44|P-value:8.26E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.84|P-value:1.25E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-4.85|P-value:5.04E-8 ID:SGTC_3090|Compound:9117696|FD-Score:-3.40|P-value:9.39E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.07|P-value:3.73E-4 ID:SGTC_3126|Compound:9127922|FD-Score:6.92|P-value:1.64E-14 ID:SGTC_3132|Compound:9126706|FD-Score:10.90|P-value:1.55E-33 ID:SGTC_3143|Compound:9086658|FD-Score:3.58|P-value:4.44E-5 ID:SGTC_3161|Compound:9100388|FD-Score:2.84|P-value:9.17E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-2.92|P-value:6.60E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.24|P-value:1.87E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.60|P-value:3.81E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.67|P-value:2.79E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.00|P-value:4.89E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.13|P-value:3.04E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.77|P-value:7.87E-8 ID:SGTC_182|Compound:3448-4371|FD-Score:7.81|P-value:5.10E-18 ID:SGTC_183|Compound:3914-0051|FD-Score:7.18|P-value:1.76E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:3.90|P-value:9.66E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.78|P-value:1.75E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.15|P-value:2.63E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.10|P-value:3.27E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.95|P-value:6.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.14|P-value:2.83E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.79|P-value:1.60E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.35|P-value:1.22E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.60|P-value:3.94E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:2.99|P-value:5.31E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.97|P-value:5.52E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.43|P-value:8.37E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:3.08|P-value:3.73E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.57|P-value:4.40E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:4.88|P-value:4.36E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.17|P-value:2.31E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:3.04|P-value:4.34E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.11|P-value:3.27E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.91|P-value:7.18E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.01|P-value:4.95E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.82|P-value:1.37E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.27|P-value:1.40E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.63|P-value:3.43E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.95|P-value:6.15E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.16|P-value:2.63E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.98|P-value:6.44E-6 ID:SGTC_1716|Compound:st033144|FD-Score:2.95|P-value:6.16E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.09|P-value:3.71E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.87|P-value:1.09E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.58|P-value:4.43E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-2.89|P-value:7.34E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.69|P-value:2.56E-5 ID:SGTC_2314|Compound:7727897|FD-Score:2.98|P-value:5.43E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.61|P-value:3.90E-10 ID:SGTC_2473|Compound:5854593|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.05|P-value:4.18E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.17|P-value:2.46E-6 ID:SGTC_2657|Compound:nystatin|FD-Score:2.87|P-value:8.34E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.12|P-value:3.13E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.00|P-value:5.95E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-2.98|P-value:5.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.10|P-value:3.25E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.03|P-value:4.51E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.44|P-value:8.26E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.84|P-value:1.25E-5 ID:SGTC_3087|Compound:9117406|FD-Score:-4.85|P-value:5.04E-8 ID:SGTC_3090|Compound:9117696|FD-Score:-3.40|P-value:9.39E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-3.07|P-value:3.73E-4 ID:SGTC_3126|Compound:9127922|FD-Score:6.92|P-value:1.64E-14 ID:SGTC_3132|Compound:9126706|FD-Score:10.90|P-value:1.55E-33 ID:SGTC_3143|Compound:9086658|FD-Score:3.58|P-value:4.44E-5 ID:SGTC_3161|Compound:9100388|FD-Score:2.84|P-value:9.17E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-2.92|P-value:6.60E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.24|P-value:1.87E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.60|P-value:3.81E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.67|P-value:2.79E-5 ID:SGTC_3200|Compound:9114385|FD-Score:-3.00|P-value:4.89E-4

Top fitness defect scores for YKR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3132 9126706 10.90 49.5 µM 1.55E-33 1 3.38E-28
2 SGTC_182 3448-4371 7.81 550.5 µM 5.10E-18 2 2.76E-15
3 SGTC_183 3914-0051 7.18 30.6 µM 1.76E-15 60S ribosome export 1 3.59E-13
4 SGTC_3126 9127922 6.92 49.5 µM 1.64E-14 fatty acid desaturase (OLE1) 13 2.30E-12
5 SGTC_2466 5983409 5.61 37.1 µM 3.90E-10 4 1.03E-8
6 SGTC_821 1114-0266 4.88 29.2 µM 4.36E-8 9 5.29E-7
7 SGTC_1160 4092-0570 4.27 10.5 µM 1.40E-6 plasma membrane duress 32 9.63E-6
8 SGTC_2645 abamectin 4.17 100.0 µM 2.46E-6 heme requiring 24 1.54E-5
9 SGTC_1765 st044815 4.09 90.4 µM 3.71E-6 22 2.18E-5
10 SGTC_2702 st077768 4.00 96.8 µM 5.95E-6 16 3.23E-5
11 SGTC_1500 4488-1866 3.98 171.0 µM 6.44E-6 RPP1 & pyrimidine depletion 18 3.46E-5
12 SGTC_184 1494-0393 3.90 24.7 µM 9.66E-6 62 4.86E-5
13 SGTC_1928 4'-methoxychalcone 3.87 40.3 µM 1.09E-5 15 5.38E-5
14 SGTC_3083 9117465 3.84 49.5 µM 1.25E-5 24 6.04E-5
15 SGTC_438 sphingosine 3.79 6.7 µM 1.60E-5 26 7.43E-5
16 SGTC_253 dyclonine 3.78 31.2 µM 1.75E-5 amide catabolism 32 7.98E-5
17 SGTC_2310 7668677 3.69 200.0 µM 2.56E-5 41 1.10E-4
18 SGTC_1164 k060-0068 3.63 93.7 µM 3.43E-5 39 1.41E-4
19 SGTC_504 lovastatin 3.60 124.0 µM 3.94E-5 17 1.58E-4
20 SGTC_2122 5258151 3.58 111.7 µM 4.43E-5 34 1.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.33E-10 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.106 6.51E-10 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.102 3.04E-9 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.100 6.65E-9 YOR129C AFI1 hom Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p
0.092 8.60E-8 YOR322C LDB19 hom Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
0.091 1.30E-7 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.090 1.92E-7 YOR192C THI72 hom Transporter of thiamine or related compound; shares sequence similarity with Thi7p
0.089 2.71E-7 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.088 3.42E-7 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.082 1.90E-6 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.082 2.21E-6 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.081 2.90E-6 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.080 3.51E-6 YNL170W_d YNL170W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.61E-6 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.080 3.65E-6 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene