YKR032W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR032W / YKR032W

Click on Significant Values for Screen Details ID:SGTC_196|Compound:k015-0023|FD-Score:-2.97|P-value:6.20E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.80|P-value:1.79E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.11|P-value:3.57E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:4.76E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:4.63|P-value:2.41E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:4.04|P-value:5.64E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.51|P-value:4.72E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:2.87|P-value:9.25E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.20|P-value:2.56E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.93|P-value:7.38E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.37|P-value:1.25E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.25|P-value:5.46E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.59|P-value:4.83E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:2.85|P-value:9.84E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-5.58|P-value:6.65E-10 ID:SGTC_1629|Compound:st005085|FD-Score:-4.48|P-value:5.56E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-5.30|P-value:4.16E-9 ID:SGTC_1638|Compound:st008370|FD-Score:-5.89|P-value:7.75E-11 ID:SGTC_1685|Compound:st024049|FD-Score:3.93|P-value:9.62E-6 ID:SGTC_1710|Compound:st031758|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.44|P-value:6.77E-7 ID:SGTC_1734|Compound:st037168|FD-Score:-3.10|P-value:3.68E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.73|P-value:2.48E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.07|P-value:4.27E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.49|P-value:7.56E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.15|P-value:3.20E-6 ID:SGTC_2458|Compound:5808907|FD-Score:3.21|P-value:2.38E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-4.12|P-value:3.65E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.79|P-value:9.85E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.60|P-value:4.60E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.92|P-value:1.01E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.45|P-value:8.84E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-3.97|P-value:7.72E-6 ID:SGTC_3240|Compound:9133527|FD-Score:-3.06|P-value:4.33E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.98|P-value:5.94E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.84|P-value:9.86E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-2.97|P-value:6.20E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.80|P-value:1.79E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.11|P-value:3.57E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.59|P-value:4.76E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:4.63|P-value:2.41E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:4.04|P-value:5.64E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.51|P-value:4.72E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:2.87|P-value:9.25E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.20|P-value:2.56E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.93|P-value:7.38E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.37|P-value:1.25E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.37|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.25|P-value:5.46E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.59|P-value:4.83E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:2.85|P-value:9.84E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-5.58|P-value:6.65E-10 ID:SGTC_1629|Compound:st005085|FD-Score:-4.48|P-value:5.56E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-5.30|P-value:4.16E-9 ID:SGTC_1638|Compound:st008370|FD-Score:-5.89|P-value:7.75E-11 ID:SGTC_1685|Compound:st024049|FD-Score:3.93|P-value:9.62E-6 ID:SGTC_1710|Compound:st031758|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.44|P-value:6.77E-7 ID:SGTC_1734|Compound:st037168|FD-Score:-3.10|P-value:3.68E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.73|P-value:2.48E-5 ID:SGTC_1939|Compound:st074455|FD-Score:3.07|P-value:4.27E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.49|P-value:7.56E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.15|P-value:3.20E-6 ID:SGTC_2458|Compound:5808907|FD-Score:3.21|P-value:2.38E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-4.12|P-value:3.65E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.79|P-value:9.85E-8 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.60|P-value:4.60E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.15|P-value:3.10E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.92|P-value:1.01E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.45|P-value:8.84E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-3.97|P-value:7.72E-6 ID:SGTC_3240|Compound:9133527|FD-Score:-3.06|P-value:4.33E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.98|P-value:5.94E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.84|P-value:9.86E-4

Top fitness defect scores for YKR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 4.79 100.0 µM 9.85E-8 13 8.49E-7
2 SGTC_455 paf C-16 4.63 10.0 µM 2.41E-7 19 1.82E-6
3 SGTC_2300 7976697 4.15 71.6 µM 3.20E-6 ERG2 28 1.65E-5
4 SGTC_515 4092-1064 4.04 102.0 µM 5.64E-6 plasma membrane duress 57 2.67E-5
5 SGTC_1685 st024049 3.93 53.1 µM 9.62E-6 TSC3-RPN4 14 4.21E-5
6 SGTC_2601 securinine 3.92 100.0 µM 1.01E-5 31 4.40E-5
7 SGTC_2571 chrysanthemic acid 3.60 100.0 µM 4.60E-5 35 1.60E-4
8 SGTC_453 enantio-paf c16 3.59 10.0 µM 4.76E-5 178 1.65E-4
9 SGTC_1464 k208-0027 3.59 110.0 µM 4.83E-5 34 1.67E-4
10 SGTC_1980 st071811 3.49 45.7 µM 7.56E-5 RPP1 & pyrimidine depletion 33 2.45E-4
11 SGTC_2603 homopterocarpin 3.45 100.0 µM 8.84E-5 65 2.79E-4
12 SGTC_1266 0828-0227 3.37 32.9 µM 1.23E-4 37 3.72E-4
13 SGTC_1620 st003704 3.24 16.5 µM 2.11E-4 38 5.89E-4
14 SGTC_2458 5808907 3.21 16.4 µM 2.38E-4 16 6.52E-4
15 SGTC_1130 3454-2858 3.20 15.9 µM 2.56E-4 NEO1 125 6.94E-4
16 SGTC_406 estrone 3.11 100.0 µM 3.57E-4 33 9.22E-4
17 SGTC_1939 st074455 3.07 53.6 µM 4.27E-4 70 0.00107
18 SGTC_1997 st073024 3.05 93.8 µM 4.66E-4 32 0.00116
19 SGTC_3290 9121031 2.98 71.4 µM 5.94E-4 43 0.00143
20 SGTC_1134 3477-0009 2.93 42.5 µM 7.38E-4 101 0.00172

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 5.81E-35 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.153 6.18E-19 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.147 1.14E-17 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.147 1.36E-17 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.145 2.79E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.144 4.67E-17 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.144 4.74E-17 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.140 3.31E-16 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.138 9.70E-16 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.134 5.74E-15 YMR229C RRP5 het RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress
0.129 5.49E-14 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.129 7.50E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.128 9.07E-14 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.127 1.45E-13 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.123 7.49E-13 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable