YKR034W / DAL80

Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR034W / DAL80

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:-3.44|P-value:3.19E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.29|P-value:5.48E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.28|P-value:9.53E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.29|P-value:6.58E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.18|P-value:7.38E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.99|P-value:3.70E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:10.80|P-value:2.03E-27 ID:SGTC_435|Compound:c-PAF|FD-Score:6.81|P-value:5.61E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:4.33E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:4.97|P-value:3.53E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.38|P-value:3.62E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.17|P-value:8.29E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.30|P-value:5.31E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.35|P-value:4.07E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.21|P-value:1.03E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.96|P-value:1.61E-9 ID:SGTC_1633|Compound:st005664|FD-Score:-3.20|P-value:7.63E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.90|P-value:4.85E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.13|P-value:1.55E-7 ID:SGTC_1738|Compound:st035555|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.91|P-value:5.20E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.31|P-value:4.63E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.42|P-value:3.22E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.12|P-value:9.81E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-4.03|P-value:3.21E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.76|P-value:8.65E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.99|P-value:3.41E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.54|P-value:2.02E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.81|P-value:7.85E-7 ID:SGTC_3045|Compound:9092950|FD-Score:-3.27|P-value:5.95E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.63|P-value:1.46E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.58|P-value:1.93E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.12|P-value:1.64E-7 ID:SGTC_3263|Compound:9137018|FD-Score:-3.50|P-value:2.62E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.44|P-value:3.19E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.29|P-value:5.48E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:4.28|P-value:9.53E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:5.29|P-value:6.58E-8 ID:SGTC_327|Compound:1273-0057|FD-Score:3.18|P-value:7.38E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.99|P-value:3.70E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:10.80|P-value:2.03E-27 ID:SGTC_435|Compound:c-PAF|FD-Score:6.81|P-value:5.61E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.37|P-value:4.33E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:4.97|P-value:3.53E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:3.38|P-value:3.62E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.17|P-value:8.29E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.30|P-value:5.31E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.35|P-value:4.07E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.21|P-value:1.03E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.96|P-value:1.61E-9 ID:SGTC_1633|Compound:st005664|FD-Score:-3.20|P-value:7.63E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.90|P-value:4.85E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.59|P-value:1.71E-4 ID:SGTC_1733|Compound:st037357|FD-Score:5.13|P-value:1.55E-7 ID:SGTC_1738|Compound:st035555|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.91|P-value:5.20E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.31|P-value:4.63E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.42|P-value:3.22E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.12|P-value:9.81E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-4.03|P-value:3.21E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.76|P-value:8.65E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.99|P-value:3.41E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.54|P-value:2.02E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_2987|Compound:9018338|FD-Score:4.81|P-value:7.85E-7 ID:SGTC_3045|Compound:9092950|FD-Score:-3.27|P-value:5.95E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.63|P-value:1.46E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.58|P-value:1.93E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.12|P-value:1.64E-7 ID:SGTC_3263|Compound:9137018|FD-Score:-3.50|P-value:2.62E-4

Top fitness defect scores for YKR034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_363 0455-0021 10.80 3.1 µM 2.03E-27 azole & statin 8 1.33E-27
2 SGTC_435 c-PAF 6.81 6.7 µM 5.61E-12 5 4.90E-12
3 SGTC_453 enantio-paf c16 5.37 10.0 µM 4.33E-8 75 4.04E-8
4 SGTC_310 1273-0058 5.29 1.1 µM 6.58E-8 mitochondrial stress 170 6.15E-8
5 SGTC_1170 0310-0127 5.21 64.8 µM 1.03E-7 5 9.66E-8
6 SGTC_1733 st037357 5.13 54.9 µM 1.55E-7 60S ribosome export 9 1.46E-7
7 SGTC_3219 9131112 5.12 49.5 µM 1.64E-7 Golgi 21 1.55E-7
8 SGTC_455 paf C-16 4.97 10.0 µM 3.53E-7 15 3.34E-7
9 SGTC_2987 9018338 4.81 71.4 µM 7.85E-7 RPP1 & pyrimidine depletion 5 7.47E-7
10 SGTC_299 1273-0059 4.28 1.4 µM 9.53E-6 22 9.21E-6
11 SGTC_231 b-estradiol 4.14 524.0 µM 1.78E-5 5 1.73E-5
12 SGTC_2720 fluspirilene 3.99 36.9 µM 3.41E-5 ERG2 14 3.33E-5
13 SGTC_1648 st011736 3.90 69.8 µM 4.85E-5 PDR1 15 4.73E-5
14 SGTC_2373 9071805 3.76 200.0 µM 8.65E-5 16 8.48E-5
15 SGTC_3051 9093778 3.63 49.5 µM 1.46E-4 5 1.43E-4
16 SGTC_1700 st030840 3.59 7.9 µM 1.71E-4 PDR1 28 1.68E-4
17 SGTC_2942 9052777 3.54 62.2 µM 2.02E-4 50 1.99E-4
18 SGTC_1939 st074455 3.50 53.6 µM 2.33E-4 43 2.30E-4
19 SGTC_2126 5251174 3.45 33.9 µM 2.85E-4 58 2.81E-4
20 SGTC_1899 st063254 3.42 59.6 µM 3.22E-4 25 3.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.260 3.77E-53 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.191 5.60E-29 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.168 9.20E-23 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.162 3.81E-21 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.148 5.65E-18 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.140 3.26E-16 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.140 3.37E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 1.12E-15 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.136 2.23E-15 YMR010W_p YMR010W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
0.134 7.10E-15 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.134 8.10E-15 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.133 1.16E-14 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.132 1.99E-14 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.130 3.34E-14 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.129 7.02E-14 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression