YKR039W / GAP1

General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR039W / GAP1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.09|P-value:2.48E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.22|P-value:7.61E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.72|P-value:1.27E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.84|P-value:7.78E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.33|P-value:9.85E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.31|P-value:5.19E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-5.52|P-value:2.67E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:5.19|P-value:1.33E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.28|P-value:6.20E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.20|P-value:7.49E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-6.10|P-value:9.03E-10 ID:SGTC_956|Compound:1185-0240|FD-Score:4.15|P-value:1.97E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:6.50|P-value:6.26E-11 ID:SGTC_962|Compound:1254-0300|FD-Score:6.60|P-value:3.07E-11 ID:SGTC_967|Compound:1306-0166|FD-Score:7.63|P-value:2.13E-14 ID:SGTC_999|Compound:4022-0066|FD-Score:3.82|P-value:7.50E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.31|P-value:1.08E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.87|P-value:6.30E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.68|P-value:2.02E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-5.00|P-value:4.11E-7 ID:SGTC_1615|Compound:st002656|FD-Score:-3.80|P-value:9.02E-5 ID:SGTC_1640|Compound:st009078|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.72|P-value:1.26E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.15|P-value:8.91E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.19|P-value:7.85E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.84|P-value:7.67E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.96|P-value:4.43E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.15|P-value:9.56E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.79|P-value:9.62E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:3.13E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.64|P-value:1.52E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.18|P-value:8.67E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.88|P-value:6.01E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.33|P-value:5.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.58|P-value:2.14E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.44|P-value:3.53E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.27|P-value:5.93E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.36|P-value:4.69E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.98|P-value:3.88E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-3.22|P-value:7.74E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.29|P-value:1.05E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:4.09|P-value:2.48E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.22|P-value:7.61E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.72|P-value:1.27E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.84|P-value:7.78E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.33|P-value:9.85E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.31|P-value:5.19E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-5.52|P-value:2.67E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:5.19|P-value:1.33E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.28|P-value:6.20E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.20|P-value:7.49E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-6.10|P-value:9.03E-10 ID:SGTC_956|Compound:1185-0240|FD-Score:4.15|P-value:1.97E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:6.50|P-value:6.26E-11 ID:SGTC_962|Compound:1254-0300|FD-Score:6.60|P-value:3.07E-11 ID:SGTC_967|Compound:1306-0166|FD-Score:7.63|P-value:2.13E-14 ID:SGTC_999|Compound:4022-0066|FD-Score:3.82|P-value:7.50E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.31|P-value:1.08E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.87|P-value:6.30E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.68|P-value:2.02E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-5.00|P-value:4.11E-7 ID:SGTC_1615|Compound:st002656|FD-Score:-3.80|P-value:9.02E-5 ID:SGTC_1640|Compound:st009078|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.72|P-value:1.26E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.15|P-value:8.91E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.19|P-value:7.85E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.84|P-value:7.67E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.96|P-value:4.43E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.15|P-value:9.56E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.79|P-value:9.62E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.21|P-value:7.11E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:3.13E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.64|P-value:1.52E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.18|P-value:8.67E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.88|P-value:6.01E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.33|P-value:5.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.58|P-value:2.14E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.44|P-value:3.53E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.70|P-value:1.36E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.27|P-value:5.93E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.36|P-value:4.69E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.98|P-value:3.88E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-3.22|P-value:7.74E-4

Top fitness defect scores for YKR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_967 1306-0166 7.63 352.0 µM 2.13E-14 1 1.19E-14
2 SGTC_962 1254-0300 6.60 21.5 µM 3.07E-11 4 2.00E-11
3 SGTC_961 1252-1571 6.50 372.0 µM 6.26E-11 5 4.14E-11
4 SGTC_669 0108-0021 5.19 26.2 µM 1.33E-7 fatty acid desaturase (OLE1) 32 1.04E-7
5 SGTC_2273 7815444 4.96 169.1 µM 4.43E-7 7 3.53E-7
6 SGTC_6 0844-0013 4.29 19.8 µM 1.05E-5 64 8.92E-6
7 SGTC_956 1185-0240 4.15 191.0 µM 1.97E-5 19 1.69E-5
8 SGTC_162 k030-0015 4.09 37.8 µM 2.48E-5 iron homeostasis 21 2.14E-5
9 SGTC_3134 9127454 3.98 49.5 µM 3.88E-5 11 3.38E-5
10 SGTC_2805 7950783 3.88 58.4 µM 6.01E-5 35 5.28E-5
11 SGTC_1406 3909-7906 3.87 11.9 µM 6.30E-5 60S ribosome export 10 5.53E-5
12 SGTC_999 4022-0066 3.82 22.7 µM 7.50E-5 Golgi 51 6.61E-5
13 SGTC_2371 9071574 3.72 200.0 µM 1.14E-4 13 1.01E-4
14 SGTC_2611 pyromycin 3.64 23.9 µM 1.52E-4 39 1.36E-4
15 SGTC_2117 5521686 3.60 200.0 µM 1.77E-4 22 1.58E-4
16 SGTC_1640 st009078 3.49 66.4 µM 2.65E-4 20 2.39E-4
17 SGTC_2276 7947513 3.38 42.1 µM 4.01E-4 39 3.64E-4
18 SGTC_595 3909-8003 3.31 73.7 µM 5.19E-4 33 4.75E-4
19 SGTC_3123 9126162 3.27 49.5 µM 5.93E-4 37 5.44E-4
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.21 3.7 µM 7.11E-4 168 6.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.41E-18 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.133 9.33E-15 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.129 5.99E-14 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.129 8.38E-14 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.126 2.75E-13 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.125 3.28E-13 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.124 4.77E-13 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.121 2.28E-12 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.121 2.23E-12 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.121 2.40E-12 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.120 3.61E-12 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.119 3.81E-12 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.119 3.84E-12 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.119 4.93E-12 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.119 5.18E-12 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress