YKR040C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR040C / YKR040C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.03|P-value:7.83E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.99|P-value:1.49E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.98|P-value:9.33E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.04|P-value:7.46E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.35|P-value:2.84E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.23|P-value:3.57E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.58|P-value:9.21E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.85|P-value:2.07E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.56|P-value:9.69E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.75|P-value:4.50E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.00|P-value:8.69E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.08|P-value:6.58E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.96|P-value:1.10E-7 ID:SGTC_2074|Compound:5212007|FD-Score:3.87|P-value:2.69E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.21|P-value:5.57E-6 ID:SGTC_2238|Compound:6671620|FD-Score:3.30|P-value:2.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.22|P-value:5.25E-6 ID:SGTC_2426|Compound:5582046|FD-Score:3.18|P-value:4.52E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.96|P-value:2.44E-10 ID:SGTC_2652|Compound:actinonin|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.34|P-value:2.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.41|P-value:1.75E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.36|P-value:2.26E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_3319|Compound:9138450|FD-Score:5.49|P-value:4.95E-9 ID:SGTC_69|Compound:0096-0274|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.03|P-value:7.83E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.99|P-value:1.49E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.13|P-value:5.40E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:2.98|P-value:9.33E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.04|P-value:7.46E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.35|P-value:2.84E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.24|P-value:3.65E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.23|P-value:3.57E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.58|P-value:9.21E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.85|P-value:2.07E-7 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.56|P-value:9.69E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.75|P-value:4.50E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.00|P-value:8.69E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.08|P-value:6.58E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.96|P-value:1.10E-7 ID:SGTC_2074|Compound:5212007|FD-Score:3.87|P-value:2.69E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.21|P-value:5.57E-6 ID:SGTC_2238|Compound:6671620|FD-Score:3.30|P-value:2.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.22|P-value:5.25E-6 ID:SGTC_2426|Compound:5582046|FD-Score:3.18|P-value:4.52E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.96|P-value:2.44E-10 ID:SGTC_2652|Compound:actinonin|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.34|P-value:2.47E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.41|P-value:1.75E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.36|P-value:2.26E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.32|P-value:2.68E-4 ID:SGTC_3319|Compound:9138450|FD-Score:5.49|P-value:4.95E-9

Top fitness defect scores for YKR040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2428 5615643 5.96 7.8 µM 2.44E-10 10 1.28E-9
2 SGTC_3319 9138450 5.49 16.8 µM 4.95E-9 5 2.03E-8
3 SGTC_1960 st011366 4.96 51.8 µM 1.10E-7 3 3.48E-7
4 SGTC_1529 apigenin 4.85 74.0 µM 2.07E-7 15 6.26E-7
5 SGTC_883 0850-0245 4.35 24.6 µM 2.84E-6 cell wall 26 6.94E-6
6 SGTC_2424 5537928 4.22 59.2 µM 5.25E-6 30 1.22E-5
7 SGTC_2133 5320837 4.21 200.0 µM 5.57E-6 ERG2 19 1.29E-5
8 SGTC_2074 5212007 3.87 75.4 µM 2.69E-5 13 5.48E-5
9 SGTC_1614 st002383 3.75 48.6 µM 4.50E-5 cell wall signaling 18 8.80E-5
10 SGTC_1514 1189-1591 3.58 158.0 µM 9.21E-5 53 1.70E-4
11 SGTC_69 0096-0274 3.56 206.7 µM 1.02E-4 mitochondrial processes 59 1.87E-4
12 SGTC_162 k030-0015 3.54 37.8 µM 1.11E-4 iron homeostasis 28 2.02E-4
13 SGTC_2091 4-phenylthiadiazole 3.45 200.0 µM 1.59E-4 28 2.81E-4
14 SGTC_2652 actinonin 3.44 100.0 µM 1.65E-4 9 2.91E-4
15 SGTC_3059 1327-0034 3.36 3.0 µM 2.26E-4 76 3.88E-4
16 SGTC_2680 butyl paraben 3.34 22.2 µM 2.47E-4 amide catabolism 21 4.22E-4
17 SGTC_3298 9116858 3.32 71.4 µM 2.68E-4 28 4.55E-4
18 SGTC_2238 6671620 3.30 73.2 µM 2.88E-4 52 4.86E-4
19 SGTC_999 4022-0066 3.24 22.7 µM 3.65E-4 Golgi 68 6.05E-4
20 SGTC_823 0417-1665 3.22 178.0 µM 3.96E-4 62 6.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.81E-13 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.125 3.11E-13 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.108 3.12E-10 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.104 1.86E-9 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.100 5.99E-9 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.098 1.13E-8 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.089 2.17E-7 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.088 2.99E-7 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.086 6.29E-7 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.085 7.13E-7 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.083 1.43E-6 YOL063C CRT10 hom Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat
0.082 1.75E-6 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.082 1.87E-6 YHL035C VMR1 hom Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
0.081 2.60E-6 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.080 3.09E-6 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.