YKR046C / PET10

Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR046C / PET10

Click on Significant Values for Screen Details ID:SGTC_342|Compound:k048-0088|FD-Score:-4.10|P-value:8.25E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.30|P-value:2.83E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.12|P-value:5.65E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.22|P-value:2.48E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:4.99|P-value:9.28E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:3.00|P-value:8.68E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.16|P-value:4.44E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.98|P-value:8.64E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.32|P-value:3.22E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.10|P-value:5.95E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.06|P-value:6.98E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.33|P-value:2.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:5.82|P-value:5.65E-10 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.83|P-value:2.87E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.03|P-value:7.35E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.09|P-value:9.44E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-4.46|P-value:1.42E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.92|P-value:1.92E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.90|P-value:2.13E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-6.86|P-value:3.18E-13 ID:SGTC_1724|Compound:st037281|FD-Score:-5.70|P-value:1.11E-9 ID:SGTC_1734|Compound:st037168|FD-Score:-3.03|P-value:7.15E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.39|P-value:2.02E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.22|P-value:3.64E-4 ID:SGTC_2277|Compound:7947813|FD-Score:2.99|P-value:9.08E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.15|P-value:7.38E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.02|P-value:7.96E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.09|P-value:6.26E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.17|P-value:4.33E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.38|P-value:2.10E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.23|P-value:3.41E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.75|P-value:4.54E-5 ID:SGTC_2825|Compound:7998094|FD-Score:-4.42|P-value:1.71E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.05|P-value:1.26E-10 ID:SGTC_2874|Compound:9043904|FD-Score:3.62|P-value:7.76E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.07|P-value:6.71E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.98|P-value:1.47E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.64|P-value:7.12E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.29|P-value:2.97E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.09|P-value:6.19E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.01|P-value:1.66E-10 ID:SGTC_3310|Compound:9130229|FD-Score:-2.95|P-value:9.70E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.73|P-value:4.40E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.05|P-value:6.70E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-4.10|P-value:8.25E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.30|P-value:2.83E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.12|P-value:5.65E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:5.22|P-value:2.48E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:4.99|P-value:9.28E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:3.00|P-value:8.68E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.16|P-value:4.44E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.98|P-value:8.64E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.32|P-value:3.22E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.10|P-value:5.95E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.06|P-value:6.98E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.33|P-value:2.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:5.82|P-value:5.65E-10 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.83|P-value:2.87E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.03|P-value:7.35E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.09|P-value:9.44E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-4.46|P-value:1.42E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.92|P-value:1.92E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.90|P-value:2.13E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-6.86|P-value:3.18E-13 ID:SGTC_1724|Compound:st037281|FD-Score:-5.70|P-value:1.11E-9 ID:SGTC_1734|Compound:st037168|FD-Score:-3.03|P-value:7.15E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.39|P-value:2.02E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.26|P-value:3.27E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.22|P-value:3.64E-4 ID:SGTC_2277|Compound:7947813|FD-Score:2.99|P-value:9.08E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.15|P-value:7.38E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.02|P-value:7.96E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.09|P-value:6.26E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.17|P-value:4.33E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.38|P-value:2.10E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.23|P-value:3.41E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.75|P-value:4.54E-5 ID:SGTC_2825|Compound:7998094|FD-Score:-4.42|P-value:1.71E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.17|P-value:4.62E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.05|P-value:1.26E-10 ID:SGTC_2874|Compound:9043904|FD-Score:3.62|P-value:7.76E-5 ID:SGTC_2929|Compound:9013348|FD-Score:3.81|P-value:3.38E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.07|P-value:6.71E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.98|P-value:1.47E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.64|P-value:7.12E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.29|P-value:2.97E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.09|P-value:6.19E-4 ID:SGTC_3210|Compound:9128157|FD-Score:6.01|P-value:1.66E-10 ID:SGTC_3310|Compound:9130229|FD-Score:-2.95|P-value:9.70E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.73|P-value:4.40E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.05|P-value:6.70E-4

Top fitness defect scores for YKR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2836 9010338 6.05 19.5 µM 1.26E-10 RPP1 & pyrimidine depletion 4 7.24E-10
2 SGTC_3210 9128157 6.01 49.5 µM 1.66E-10 15 9.31E-10
3 SGTC_1124 fisetin 5.82 1.2 µM 5.65E-10 6 2.86E-9
4 SGTC_361 000s-0510 5.22 1.4 µM 2.48E-8 14 9.11E-8
5 SGTC_362 0310-0100 4.99 9.0 µM 9.28E-8 RPP1 & pyrimidine depletion 12 3.06E-7
6 SGTC_827 3253-0474 4.32 693.0 µM 3.22E-6 11 7.89E-6
7 SGTC_2321 7390090 4.15 138.8 µM 7.38E-6 20 1.69E-5
8 SGTC_1557 sumaresinolic acid 4.09 42.3 µM 9.44E-6 17 2.11E-5
9 SGTC_2929 9013348 3.81 24.6 µM 3.38E-5 25 6.83E-5
10 SGTC_2823 7987624 3.75 58.4 µM 4.54E-5 35 8.94E-5
11 SGTC_3026 9090633 3.64 49.5 µM 7.12E-5 34 1.35E-4
12 SGTC_2874 9043904 3.62 71.4 µM 7.76E-5 20 1.46E-4
13 SGTC_1783 st039459 3.39 87.5 µM 2.02E-4 Golgi 39 3.52E-4
14 SGTC_2724 maprotiline 3.38 69.6 µM 2.10E-4 ERG2 30 3.65E-4
15 SGTC_1069 diphenylcyclopropenone 3.33 8.5 µM 2.52E-4 52 4.33E-4
16 SGTC_343 4130-2827 3.30 29.8 µM 2.83E-4 55 4.81E-4
17 SGTC_3044 9093193 3.29 49.5 µM 2.97E-4 53 5.02E-4
18 SGTC_1968 st069590 3.26 43.6 µM 3.27E-4 31 5.50E-4
19 SGTC_2833 9001315 3.17 45.5 µM 4.62E-4 amide catabolism 90 7.54E-4
20 SGTC_2721 ifenprodil 3.15 61.4 µM 5.03E-4 plasma membrane duress 50 8.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.69E-9 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.102 3.46E-9 YNR024W MPP6 hom Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
0.100 7.35E-9 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.099 9.20E-9 YER085C_p YER085C_p hom Putative protein of unknown function
0.093 5.83E-8 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.091 1.36E-7 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.091 1.36E-7 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.091 1.49E-7 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.089 2.60E-7 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.088 3.01E-7 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.088 3.50E-7 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.088 3.50E-7 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.087 4.37E-7 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.085 8.77E-7 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.084 1.29E-6 YGR113W DAM1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments