YKR048C / NAP1

Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR048C / NAP1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.20|P-value:1.25E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:3.62|P-value:1.41E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.40|P-value:2.57E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.36|P-value:2.94E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.65|P-value:1.29E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.35|P-value:6.50E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.84|P-value:5.94E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.48|P-value:2.47E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.53|P-value:1.54E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.49|P-value:3.25E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:4.71|P-value:1.12E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:5.42|P-value:2.52E-8 ID:SGTC_870|Compound:0573-2213|FD-Score:4.22|P-value:1.15E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.89|P-value:4.86E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.10|P-value:9.63E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.74|P-value:9.57E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.25|P-value:5.75E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.79|P-value:7.17E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.94|P-value:3.95E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.77|P-value:5.94E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.12|P-value:9.11E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.98|P-value:3.32E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.28|P-value:8.90E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.18|P-value:7.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.45|P-value:2.06E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.17|P-value:7.49E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.02|P-value:9.95E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.08|P-value:1.56E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.19|P-value:1.33E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.85|P-value:5.54E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.29|P-value:6.06E-6 ID:SGTC_1900|Compound:st060200|FD-Score:3.16|P-value:7.89E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.32|P-value:4.54E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.19|P-value:7.20E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.21|P-value:5.15E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.97|P-value:3.39E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.19|P-value:7.06E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.31|P-value:4.69E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.59|P-value:1.59E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.70|P-value:1.20E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.45|P-value:4.31E-11 ID:SGTC_2368|Compound:9071271|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.29|P-value:4.94E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.05|P-value:1.91E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.18|P-value:7.24E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.45|P-value:4.05E-6 ID:SGTC_2715|Compound:st079500|FD-Score:3.17|P-value:7.73E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.45|P-value:2.80E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.00|P-value:3.06E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.44|P-value:4.12E-6 ID:SGTC_3062|Compound:9077494|FD-Score:6.67|P-value:9.28E-12 ID:SGTC_3187|Compound:9109394|FD-Score:3.32|P-value:4.44E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.13|P-value:6.85E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.50|P-value:2.25E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.20|P-value:5.34E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.66|P-value:1.23E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.16|P-value:7.89E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.20|P-value:1.25E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:3.62|P-value:1.41E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.17|P-value:5.77E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.40|P-value:2.57E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.36|P-value:2.94E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.65|P-value:1.29E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.35|P-value:6.50E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.84|P-value:5.94E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.48|P-value:2.47E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.53|P-value:1.54E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.49|P-value:3.25E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:4.71|P-value:1.12E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:5.42|P-value:2.52E-8 ID:SGTC_870|Compound:0573-2213|FD-Score:4.22|P-value:1.15E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.89|P-value:4.86E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.10|P-value:9.63E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.74|P-value:9.57E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.25|P-value:5.75E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.79|P-value:7.17E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.07|P-value:2.26E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.94|P-value:3.95E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.77|P-value:5.94E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.12|P-value:9.11E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.98|P-value:3.32E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.28|P-value:8.90E-6 ID:SGTC_1622|Compound:st003707|FD-Score:3.18|P-value:7.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.45|P-value:2.06E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.17|P-value:7.49E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.02|P-value:9.95E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.08|P-value:1.56E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.19|P-value:1.33E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.85|P-value:5.54E-7 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.29|P-value:6.06E-6 ID:SGTC_1900|Compound:st060200|FD-Score:3.16|P-value:7.89E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.32|P-value:4.54E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.19|P-value:7.20E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.21|P-value:5.15E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.97|P-value:3.39E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.19|P-value:7.06E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.31|P-value:4.69E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.59|P-value:1.59E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.70|P-value:1.20E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:6.45|P-value:4.31E-11 ID:SGTC_2368|Compound:9071271|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.29|P-value:4.94E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.05|P-value:1.91E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.18|P-value:7.24E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.45|P-value:4.05E-6 ID:SGTC_2715|Compound:st079500|FD-Score:3.17|P-value:7.73E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.45|P-value:2.80E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.00|P-value:3.06E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.44|P-value:4.12E-6 ID:SGTC_3062|Compound:9077494|FD-Score:6.67|P-value:9.28E-12 ID:SGTC_3187|Compound:9109394|FD-Score:3.32|P-value:4.44E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.13|P-value:6.85E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.50|P-value:2.25E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.20|P-value:5.34E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.66|P-value:1.23E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.16|P-value:7.89E-4

Top fitness defect scores for YKR048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3062 9077494 6.67 49.5 µM 9.28E-12 mitochondrial response to ROS 8 1.25E-11
2 SGTC_2251 lansoprazole 6.45 556.0 µM 4.31E-11 5 5.63E-11
3 SGTC_854 0422-0053 5.42 192.0 µM 2.52E-8 PDR1 3 2.95E-8
4 SGTC_2419 paclitaxel 5.05 166.5 µM 1.91E-7 14 2.16E-7
5 SGTC_1785 bathophenanthroline 4.85 24.0 µM 5.54E-7 heme requiring 23 6.16E-7
6 SGTC_1075 aripiprazole 4.74 15.2 µM 9.57E-7 11 1.06E-6
7 SGTC_835 0312-0010 4.71 67.2 µM 1.12E-6 4 1.24E-6
8 SGTC_2247 cerulenin 4.70 830.0 nM 1.20E-6 6 1.32E-6
9 SGTC_828 2074-0507 4.49 139.0 µM 3.25E-6 RPP1 & pyrimidine depletion 15 3.51E-6
10 SGTC_2674 ligustilide 4.45 100.0 µM 4.05E-6 4 4.37E-6
11 SGTC_3008 9078912 4.44 71.4 µM 4.12E-6 6 4.44E-6
12 SGTC_266 formosanin C 4.35 406.0 nM 6.50E-6 sphingolipid biosynthesis & PDR1 56 6.96E-6
13 SGTC_1597 7-benzyloxygramine 4.28 47.5 µM 8.90E-6 calcium & mitochondrial duress 102 9.49E-6
14 SGTC_870 0573-2213 4.22 57.6 µM 1.15E-5 ERG2 14 1.22E-5
15 SGTC_9 0092-0002 4.20 10.4 µM 1.25E-5 23 1.33E-5
16 SGTC_1744 st037937 4.19 38.9 µM 1.33E-5 23 1.41E-5
17 SGTC_1285 0929-0069 4.07 65.5 µM 2.26E-5 10 2.37E-5
18 SGTC_2960 9079389 4.00 6.0 µM 3.06E-5 28 3.21E-5
19 SGTC_1509 1326-1131 3.98 80.0 µM 3.32E-5 12 3.47E-5
20 SGTC_558 k064-0027 3.97 21.3 µM 3.37E-5 DNA damage response 24 3.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.02E-14 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.13E-10 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.105 1.15E-9 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.100 6.85E-9 YER111C SWI4 hom DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
0.098 1.37E-8 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.094 4.22E-8 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.093 6.41E-8 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.089 2.12E-7 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.089 2.67E-7 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.088 2.98E-7 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.088 2.99E-7 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.087 5.22E-7 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.18E-7 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.085 9.86E-7 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.084 1.18E-6 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor