YKR049C / FMP46

Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR049C / FMP46

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:5.07|P-value:9.42E-8 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.14|P-value:7.97E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.16|P-value:7.31E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.47|P-value:1.69E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.83|P-value:5.62E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.39|P-value:3.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.68|P-value:1.72E-15 ID:SGTC_726|Compound:3448-4391|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.38|P-value:3.20E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.19|P-value:6.57E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.56|P-value:1.66E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.39|P-value:3.07E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.57|P-value:1.61E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.60|P-value:1.09E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.41|P-value:2.93E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.12|P-value:8.54E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.91|P-value:2.76E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.11|P-value:6.47E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.82|P-value:4.01E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.97|P-value:2.15E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.02|P-value:8.96E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.69|P-value:7.18E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.22|P-value:4.42E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.15|P-value:5.67E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.07|P-value:7.52E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.31|P-value:4.34E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.67|P-value:7.78E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-3.35|P-value:3.72E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-5.21|P-value:6.90E-8 ID:SGTC_2012|Compound:4023501|FD-Score:-4.85|P-value:4.67E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.11|P-value:6.62E-4 ID:SGTC_2204|Compound:7233102|FD-Score:2.99|P-value:9.79E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.07|P-value:7.63E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.05|P-value:8.16E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.98|P-value:2.08E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.02|P-value:8.87E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.04|P-value:8.28E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.00|P-value:9.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.21|P-value:7.11E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.49|P-value:1.57E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.77|P-value:5.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.06|P-value:9.93E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.96|P-value:3.26E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.40|P-value:2.92E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.25|P-value:3.90E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.28|P-value:5.31E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:5.07|P-value:9.42E-8 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.14|P-value:7.97E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.16|P-value:7.31E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.47|P-value:1.69E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.83|P-value:5.62E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.39|P-value:3.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:7.68|P-value:1.72E-15 ID:SGTC_726|Compound:3448-4391|FD-Score:3.10|P-value:6.70E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.28|P-value:3.49E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.38|P-value:3.20E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.19|P-value:6.57E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.56|P-value:1.66E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.39|P-value:3.07E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.57|P-value:1.61E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.60|P-value:1.09E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.41|P-value:2.93E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.12|P-value:8.54E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.91|P-value:2.76E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.11|P-value:6.47E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.82|P-value:4.01E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.97|P-value:2.15E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.02|P-value:8.96E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.69|P-value:7.18E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.22|P-value:4.42E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.15|P-value:5.67E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.07|P-value:7.52E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.31|P-value:4.34E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.67|P-value:7.78E-5 ID:SGTC_1853|Compound:st056710|FD-Score:-3.35|P-value:3.72E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.16|P-value:7.29E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-5.21|P-value:6.90E-8 ID:SGTC_2012|Compound:4023501|FD-Score:-4.85|P-value:4.67E-7 ID:SGTC_2186|Compound:6124449|FD-Score:3.11|P-value:6.62E-4 ID:SGTC_2204|Compound:7233102|FD-Score:2.99|P-value:9.79E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.07|P-value:7.63E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.05|P-value:8.16E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.98|P-value:2.08E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.02|P-value:8.87E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.04|P-value:8.28E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.00|P-value:9.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.21|P-value:7.11E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.49|P-value:1.57E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.77|P-value:5.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:5.06|P-value:9.93E-8 ID:SGTC_2981|Compound:9013952|FD-Score:-3.96|P-value:3.26E-5 ID:SGTC_2998|Compound:9066762|FD-Score:4.40|P-value:2.92E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.25|P-value:3.90E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.28|P-value:5.31E-6

Top fitness defect scores for YKR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 7.68 26.2 µM 1.72E-15 fatty acid desaturase (OLE1) 14 8.12E-15
2 SGTC_74 000s-0487 5.07 160.3 µM 9.42E-8 11 2.03E-7
3 SGTC_2978 9011784 5.06 43.0 µM 9.93E-8 12 2.13E-7
4 SGTC_1054 3429-0080 4.60 167.0 µM 1.09E-6 24 2.11E-6
5 SGTC_2998 9066762 4.40 71.4 µM 2.92E-6 RPP1 & pyrimidine depletion 18 5.38E-6
6 SGTC_1050 3232-1156 4.39 69.3 µM 3.07E-6 RSC complex & mRNA processing 13 5.64E-6
7 SGTC_1011 4112-3381 4.38 17.4 µM 3.20E-6 30 5.87E-6
8 SGTC_3137 9097352 4.28 49.5 µM 5.31E-6 36 9.51E-6
9 SGTC_2794 7785382 4.21 27.3 µM 7.11E-6 27 1.26E-5
10 SGTC_2415 st077333 3.98 57.7 µM 2.08E-5 41 3.50E-5
11 SGTC_1363 1636-0063 3.97 10.4 µM 2.15E-5 Golgi 28 3.62E-5
12 SGTC_1239 0337-0584 3.91 35.4 µM 2.76E-5 unfolded protein response 56 4.58E-5
13 SGTC_1265 0819-1001 3.82 68.8 µM 4.01E-5 29 6.55E-5
14 SGTC_2967 9089538 3.77 49.9 µM 5.12E-5 39 8.27E-5
15 SGTC_1524 corynanthine 3.69 62.1 µM 7.18E-5 26 1.14E-4
16 SGTC_1851 st056236 3.67 18.9 µM 7.78E-5 20 1.23E-4
17 SGTC_3047 9092122 3.52 49.5 µM 1.41E-4 36 2.17E-4
18 SGTC_2800 7887935 3.49 81.8 µM 1.57E-4 RPP1 & pyrimidine depletion 52 2.41E-4
19 SGTC_430 0958-0115 3.47 16.4 µM 1.69E-4 48 2.58E-4
20 SGTC_987 1497-1013 3.28 404.0 µM 3.49E-4 32 5.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.50E-17 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.132 2.03E-14 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.123 8.88E-13 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.118 6.02E-12 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.109 2.56E-10 YNL023C FAP1 hom Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
0.107 5.88E-10 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.106 6.59E-10 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.105 9.25E-10 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.105 1.27E-9 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.101 4.54E-9 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.094 5.49E-8 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.094 5.43E-8 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.089 2.13E-7 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.67E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.087 4.78E-7 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene