YKR050W / TRK2

Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR050W / TRK2

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.75|P-value:1.07E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.16|P-value:8.90E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.58|P-value:4.33E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.30|P-value:5.64E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.91|P-value:5.74E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.92|P-value:7.15E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-5.22|P-value:1.38E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.61|P-value:1.82E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.92|P-value:7.19E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.56|P-value:2.83E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.37|P-value:5.62E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.85|P-value:9.67E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.70|P-value:1.29E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.63|P-value:2.21E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.58|P-value:2.63E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.89|P-value:1.04E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.25|P-value:6.60E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.31|P-value:5.47E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.92|P-value:5.49E-5 ID:SGTC_3035|Compound:9091303|FD-Score:4.15|P-value:2.85E-5 ID:SGTC_3040|Compound:9091894|FD-Score:-4.43|P-value:6.34E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-5.16|P-value:1.86E-7 ID:SGTC_3309|Compound:9129340|FD-Score:5.36|P-value:9.44E-8 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.75|P-value:1.07E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.16|P-value:8.90E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.58|P-value:4.33E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.30|P-value:5.64E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.91|P-value:5.74E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.92|P-value:7.15E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-5.22|P-value:1.38E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.61|P-value:1.82E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.92|P-value:7.19E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.56|P-value:2.83E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.49|P-value:3.67E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.37|P-value:5.62E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.85|P-value:9.67E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-3.70|P-value:1.29E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.63|P-value:2.21E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.58|P-value:2.63E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.89|P-value:1.04E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.25|P-value:6.60E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.31|P-value:5.47E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-3.92|P-value:5.49E-5 ID:SGTC_3035|Compound:9091303|FD-Score:4.15|P-value:2.85E-5 ID:SGTC_3040|Compound:9091894|FD-Score:-4.43|P-value:6.34E-6 ID:SGTC_3043|Compound:9092303|FD-Score:-5.16|P-value:1.86E-7 ID:SGTC_3309|Compound:9129340|FD-Score:5.36|P-value:9.44E-8

Top fitness defect scores for YKR050W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3309 9129340 5.36 25.8 µM 9.44E-8 4 4.10E-8
2 SGTC_2572 astragaloside iv 4.89 100.0 µM 1.04E-6 9 5.11E-7
3 SGTC_521 r062-0005 4.58 13.8 µM 4.33E-6 8 2.28E-6
4 SGTC_3035 9091303 4.15 49.5 µM 2.85E-5 5 1.65E-5
5 SGTC_1911 st060208 4.00 74.3 µM 5.19E-5 34 3.11E-5
6 SGTC_737 1950-0117 3.92 57.9 µM 7.15E-5 25 4.36E-5
7 SGTC_920 mycophenolic acid 3.92 780.4 nM 7.19E-5 30 4.39E-5
8 SGTC_1588 farnesol 3.85 29.9 µM 9.67E-5 11 5.99E-5
9 SGTC_2578 7,8-dihydroxyflavone 3.83 64.4 µM 1.04E-4 32 6.44E-5
10 SGTC_1753 st043925 3.63 64.0 µM 2.21E-4 12 1.43E-4
11 SGTC_1942 st076330 3.58 65.2 µM 2.63E-4 38 1.72E-4
12 SGTC_1114 scopoletin 3.56 1.7 µM 2.83E-4 27 1.85E-4
13 SGTC_1118 chelidonine 3.49 707.5 nM 3.67E-4 29 2.43E-4
14 SGTC_1212 0520-0165 3.37 585.0 µM 5.62E-4 56 3.82E-4
15 SGTC_361 000s-0510 3.15 1.4 µM 0.00114 69 8.04E-4
16 SGTC_6 0844-0013 3.12 19.8 µM 0.00127 186 9.04E-4
17 SGTC_130 0136-0219 3.10 337.7 µM 0.00134 60 9.56E-4
18 SGTC_3000 9075062 3.09 71.4 µM 0.00139 54 9.89E-4
19 SGTC_3325 9138760 3.07 55.2 µM 0.00150 Golgi 53 0.00107
20 SGTC_897 1000-0139 3.03 31.4 µM 0.00171 52 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.51E-19 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.145 3.08E-17 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.131 2.63E-14 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.110 1.48E-10 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.105 9.39E-10 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.105 9.56E-10 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.097 2.11E-8 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.092 8.66E-8 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.092 1.07E-7 YGR014W MSB2 hom Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.091 1.10E-7 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.090 1.84E-7 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.088 2.94E-7 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.088 3.58E-7 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.087 4.78E-7 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.28E-7 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication