YKR051W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR051W / YKR051W

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.09|P-value:3.56E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:5.42|P-value:7.23E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.52|P-value:3.19E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.35|P-value:5.69E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.92|P-value:9.01E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.21|P-value:9.22E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:7.76|P-value:2.53E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:5.46|P-value:5.84E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:3.49|P-value:3.47E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:7.70E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.47|P-value:3.73E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.26|P-value:7.89E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.72|P-value:1.51E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.76|P-value:1.95E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.46|P-value:3.86E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.84|P-value:9.83E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.25|P-value:1.73E-7 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.21|P-value:9.06E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.65|P-value:1.94E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.06|P-value:4.60E-7 ID:SGTC_1778|Compound:st046819|FD-Score:5.25|P-value:1.74E-7 ID:SGTC_1846|Compound:st056244|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.76|P-value:1.29E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.41|P-value:4.70E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.26|P-value:7.69E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.73|P-value:1.45E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_2163|Compound:5671233|FD-Score:-3.93|P-value:6.66E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.36|P-value:5.50E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.73|P-value:1.34E-8 ID:SGTC_2817|Compound:7995342|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.67|P-value:1.82E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.39|P-value:4.89E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.61|P-value:3.76E-6 ID:SGTC_3195|Compound:9113082|FD-Score:5.22|P-value:2.02E-7 ID:SGTC_3207|Compound:9114163|FD-Score:-4.55|P-value:4.93E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:4.09|P-value:3.56E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:5.42|P-value:7.23E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.52|P-value:3.19E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.35|P-value:5.69E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.92|P-value:9.01E-7 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.21|P-value:9.22E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:7.76|P-value:2.53E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:5.46|P-value:5.84E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:3.49|P-value:3.47E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:7.70E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.47|P-value:3.73E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.26|P-value:7.89E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.72|P-value:1.51E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.76|P-value:1.95E-6 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.46|P-value:3.86E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.84|P-value:9.83E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.25|P-value:1.73E-7 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.21|P-value:9.06E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.65|P-value:1.94E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.06|P-value:4.60E-7 ID:SGTC_1778|Compound:st046819|FD-Score:5.25|P-value:1.74E-7 ID:SGTC_1846|Compound:st056244|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.76|P-value:1.29E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.39|P-value:5.00E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.41|P-value:4.70E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.26|P-value:7.69E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.73|P-value:1.45E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_2163|Compound:5671233|FD-Score:-3.93|P-value:6.66E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.36|P-value:5.50E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.35|P-value:5.68E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.73|P-value:1.34E-8 ID:SGTC_2817|Compound:7995342|FD-Score:3.52|P-value:3.19E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.67|P-value:1.82E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.39|P-value:4.89E-4 ID:SGTC_3182|Compound:9108849|FD-Score:4.61|P-value:3.76E-6 ID:SGTC_3195|Compound:9113082|FD-Score:5.22|P-value:2.02E-7 ID:SGTC_3207|Compound:9114163|FD-Score:-4.55|P-value:4.93E-6

Top fitness defect scores for YKR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_296 1222-0039 7.76 74.9 µM 2.53E-14 3 4.38E-15
2 SGTC_2782 7736369 5.73 71.4 µM 1.34E-8 10 5.08E-9
3 SGTC_518 1021-0119 5.46 62.6 µM 5.84E-8 ERG2 11 2.41E-8
4 SGTC_74 000s-0487 5.42 160.3 µM 7.23E-8 9 3.02E-8
5 SGTC_1292 0kpi-0043 5.25 232.0 µM 1.73E-7 4 7.62E-8
6 SGTC_1778 st046819 5.25 58.9 µM 1.74E-7 10 7.67E-8
7 SGTC_3195 9113082 5.22 49.5 µM 2.02E-7 7 8.98E-8
8 SGTC_1772 st048439 5.06 82.2 µM 4.60E-7 18 2.14E-7
9 SGTC_1098 clofazimine 4.76 15.1 µM 1.95E-6 heme biosynthesis & mitochondrial translocase 9 9.88E-7
10 SGTC_3182 9108849 4.61 49.5 µM 3.76E-6 RPP1 & pyrimidine depletion 5 1.98E-6
11 SGTC_2068 5226020 4.23 147.0 µM 2.05E-5 24 1.19E-5
12 SGTC_18 0111-0177 4.09 500.0 nM 3.56E-5 68 2.14E-5
13 SGTC_1186 1319-0216 3.84 26.0 µM 9.83E-5 20 6.26E-5
14 SGTC_1864 st057645 3.76 30.4 µM 1.29E-4 amide catabolism 7 8.36E-5
15 SGTC_1085 doxorubicin 3.72 7.7 µM 1.51E-4 anthracycline transcription coupled DNA repair 26 9.84E-5
16 SGTC_1846 st056244 3.72 14.8 µM 1.52E-4 37 9.93E-5
17 SGTC_618 k072-0232 3.72 33.2 µM 1.54E-4 60S ribosome export 10 1.01E-4
18 SGTC_2914 7968218 3.67 45.3 µM 1.82E-4 18 1.20E-4
19 SGTC_1485 3909-9022 3.65 254.0 µM 1.94E-4 RPP1 & pyrimidine depletion 14 1.29E-4
20 SGTC_199 4063-0024 3.52 41.6 µM 3.19E-4 9 2.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.04E-9 YBR014C GRX7 hom Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication
0.097 1.56E-8 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
0.095 3.98E-8 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.093 7.08E-8 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.090 1.58E-7 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.090 1.83E-7 YGL139W FLC3 hom Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
0.087 4.27E-7 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.078 6.64E-6 YDR322C-A TIM11 hom Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
0.077 8.14E-6 YKR098C UBP11 hom Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.076 1.12E-5 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function
0.072 2.96E-5 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.072 3.14E-5 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.070 4.94E-5 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.068 7.71E-5 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.066 1.36E-4 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C