YKR052C / MRS4

Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR052C / MRS4

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.60|P-value:8.64E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:6.02|P-value:2.27E-10 ID:SGTC_3|Compound:0833-0587|FD-Score:6.94|P-value:3.60E-13 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.62|P-value:1.36E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.90|P-value:4.92E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:3.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.46|P-value:2.48E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.50|P-value:5.98E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.44|P-value:1.99E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.38|P-value:2.05E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.28|P-value:4.87E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.08|P-value:6.25E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.49|P-value:2.27E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.96|P-value:9.66E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.37|P-value:2.20E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.01|P-value:8.12E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.71|P-value:5.39E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.63|P-value:1.31E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.18|P-value:4.39E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.14|P-value:8.26E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:9.29E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-5.65|P-value:5.19E-9 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.00|P-value:8.30E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.94|P-value:2.08E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.40|P-value:1.06E-8 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.36|P-value:3.62E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.33|P-value:2.47E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.96|P-value:9.61E-4 ID:SGTC_1650|Compound:st011916|FD-Score:4.09|P-value:1.04E-5 ID:SGTC_1672|Compound:st016598|FD-Score:6.55|P-value:6.13E-12 ID:SGTC_1677|Compound:st019204|FD-Score:-7.22|P-value:1.11E-13 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.11|P-value:8.89E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.19|P-value:6.66E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.56|P-value:1.06E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.10|P-value:9.52E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.98|P-value:8.89E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_2395|Compound:5646831|FD-Score:4.58|P-value:9.74E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.25|P-value:5.47E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.04|P-value:7.32E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.26|P-value:3.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.20|P-value:6.52E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.25|P-value:3.40E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.71|P-value:9.41E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.80|P-value:6.58E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.56|P-value:1.04E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.07|P-value:1.34E-13 ID:SGTC_2928|Compound:9011484|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.83|P-value:3.24E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.22|P-value:3.80E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.82|P-value:8.34E-10 ID:SGTC_3152|Compound:9099253|FD-Score:4.59|P-value:9.02E-7 ID:SGTC_1|Compound:0258-0098|FD-Score:3.60|P-value:8.64E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:6.02|P-value:2.27E-10 ID:SGTC_3|Compound:0833-0587|FD-Score:6.94|P-value:3.60E-13 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.62|P-value:1.36E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.90|P-value:4.92E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:3.82E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.46|P-value:2.48E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.50|P-value:5.98E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:4.44|P-value:1.99E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.54|P-value:1.10E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.38|P-value:2.05E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.28|P-value:4.87E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.08|P-value:6.25E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.49|P-value:2.27E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.96|P-value:9.66E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.37|P-value:2.20E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.44|P-value:1.65E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.01|P-value:8.12E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.71|P-value:5.39E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.63|P-value:1.31E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.18|P-value:4.39E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.14|P-value:8.26E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:9.29E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-5.65|P-value:5.19E-9 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.00|P-value:8.30E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.94|P-value:2.08E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.40|P-value:1.06E-8 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.36|P-value:3.62E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.33|P-value:2.47E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.40|P-value:1.93E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:2.96|P-value:9.61E-4 ID:SGTC_1650|Compound:st011916|FD-Score:4.09|P-value:1.04E-5 ID:SGTC_1672|Compound:st016598|FD-Score:6.55|P-value:6.13E-12 ID:SGTC_1677|Compound:st019204|FD-Score:-7.22|P-value:1.11E-13 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.11|P-value:8.89E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.19|P-value:6.66E-6 ID:SGTC_1962|Compound:st076595|FD-Score:4.56|P-value:1.06E-6 ID:SGTC_2019|Compound:4016004|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.10|P-value:9.52E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.98|P-value:8.89E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_2395|Compound:5646831|FD-Score:4.58|P-value:9.74E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.25|P-value:5.47E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.04|P-value:7.32E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.26|P-value:3.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.20|P-value:6.52E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.25|P-value:3.40E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.38|P-value:2.08E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.71|P-value:9.41E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.80|P-value:6.58E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.56|P-value:1.04E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.07|P-value:1.34E-13 ID:SGTC_2928|Compound:9011484|FD-Score:3.27|P-value:3.14E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.83|P-value:3.24E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.98|P-value:1.71E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.22|P-value:3.80E-4 ID:SGTC_3018|Compound:9082602|FD-Score:5.82|P-value:8.34E-10 ID:SGTC_3152|Compound:9099253|FD-Score:4.59|P-value:9.02E-7

Top fitness defect scores for YKR052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2925 9010536 7.07 32.5 µM 1.34E-13 azole & statin 9 7.79E-13
2 SGTC_3 0833-0587 6.94 95.6 µM 3.60E-13 redox potentiating 5 1.98E-12
3 SGTC_1672 st016598 6.55 6.5 µM 6.13E-12 endomembrane recycling 27 2.89E-11
4 SGTC_2 0422-0095 6.02 29.0 µM 2.27E-10 redox potentiating 2 8.76E-10
5 SGTC_102 gallobenzophenone 5.90 83.6 µM 4.92E-10 redox potentiating 14 1.82E-9
6 SGTC_3018 9082602 5.82 49.5 µM 8.34E-10 31 2.99E-9
7 SGTC_279 1273-0055 5.50 2.9 µM 5.98E-9 azole & statin 18 1.92E-8
8 SGTC_1317 1273-0028 5.40 910.0 nM 1.06E-8 azole & statin 32 3.29E-8
9 SGTC_3152 9099253 4.59 49.5 µM 9.02E-7 NEO1-PIK1 100 2.17E-6
10 SGTC_2395 5646831 4.58 180.2 µM 9.74E-7 15 2.33E-6
11 SGTC_1962 st076595 4.56 64.5 µM 1.06E-6 redox potentiating 15 2.52E-6
12 SGTC_327 1273-0057 4.44 4.0 µM 1.99E-6 azole & statin 19 4.56E-6
13 SGTC_1712 st032288 4.19 53.4 µM 6.66E-6 calcium & mitochondrial duress 171 1.43E-5
14 SGTC_927 2425-1185 4.14 123.0 µM 8.26E-6 24 1.75E-5
15 SGTC_2019 4016004 4.09 108.0 µM 1.02E-5 28 2.13E-5
16 SGTC_1650 st011916 4.09 45.8 µM 1.04E-5 10 2.16E-5
17 SGTC_2263 7948595 4.05 193.3 µM 1.27E-5 3 2.61E-5
18 SGTC_913 3487-1245 3.98 167.0 µM 1.71E-5 28 3.45E-5
19 SGTC_2991 9074669 3.98 71.4 µM 1.71E-5 azole & statin 62 3.47E-5
20 SGTC_1311 1190-0148 3.94 100.0 µM 2.08E-5 azole & statin 29 4.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 3.58E-43 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.179 1.79E-25 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.169 5.49E-23 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.163 2.66E-21 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.161 5.44E-21 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.160 1.02E-20 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.138 1.13E-15 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.135 4.01E-15 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.133 1.29E-14 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.125 4.16E-13 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.115 2.75E-11 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.114 3.40E-11 YLR228C ECM22 hom Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.113 6.05E-11 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.110 1.77E-10 YDR011W SNQ2 hom Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
0.108 3.06E-10 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane