YKR055W / RHO4

Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR055W / RHO4

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.27|P-value:5.10E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.12|P-value:6.36E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.65|P-value:7.96E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:6.16|P-value:9.78E-11 ID:SGTC_670|Compound:4204-0025|FD-Score:4.74|P-value:4.87E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:5.39|P-value:1.24E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.74|P-value:5.75E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.03|P-value:1.54E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.61|P-value:9.39E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.61|P-value:9.47E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.73|P-value:5.74E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:4.41|P-value:2.54E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.00|P-value:1.83E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.49|P-value:6.98E-9 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.42|P-value:2.42E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.17|P-value:8.24E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.69|P-value:6.86E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.25|P-value:3.88E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.01|P-value:9.20E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.03|P-value:8.56E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.12|P-value:1.01E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.96|P-value:3.71E-10 ID:SGTC_1769|Compound:st044406|FD-Score:-3.31|P-value:3.25E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.97|P-value:2.07E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.34|P-value:2.80E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.09|P-value:7.02E-4 ID:SGTC_2011|Compound:4012611|FD-Score:6.12|P-value:1.27E-10 ID:SGTC_2064|Compound:5220758|FD-Score:3.20|P-value:4.68E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.16|P-value:5.35E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.88|P-value:3.11E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.17|P-value:8.07E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.15|P-value:5.71E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.78|P-value:4.59E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.86|P-value:3.29E-5 ID:SGTC_2341|Compound:7987486|FD-Score:-3.06|P-value:8.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.77|P-value:4.92E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.35|P-value:2.70E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:5.14|P-value:5.35E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.67|P-value:2.38E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.49|P-value:1.56E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.37|P-value:2.58E-4 ID:SGTC_2819|Compound:7996655|FD-Score:6.04|P-value:2.12E-10 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:4.42E-5 ID:SGTC_2828|Compound:7998861|FD-Score:-4.44|P-value:2.27E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.51|P-value:1.49E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.92|P-value:2.49E-5 ID:SGTC_2924|Compound:9010168|FD-Score:5.18|P-value:4.26E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.36|P-value:2.65E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.14|P-value:5.84E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.15|P-value:8.76E-6 ID:SGTC_14|Compound:0354-0009|FD-Score:4.27|P-value:5.10E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.12|P-value:6.36E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.65|P-value:7.96E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.08|P-value:1.24E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:6.16|P-value:9.78E-11 ID:SGTC_670|Compound:4204-0025|FD-Score:4.74|P-value:4.87E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:5.39|P-value:1.24E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.74|P-value:5.75E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.03|P-value:1.54E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.61|P-value:9.39E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.61|P-value:9.47E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.73|P-value:5.74E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:4.41|P-value:2.54E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.00|P-value:1.83E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.49|P-value:6.98E-9 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.42|P-value:2.42E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.17|P-value:8.24E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.69|P-value:6.86E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.51|P-value:1.42E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.53|P-value:1.29E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.25|P-value:3.88E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.01|P-value:9.20E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.03|P-value:8.56E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.12|P-value:1.01E-5 ID:SGTC_1676|Compound:st018489|FD-Score:5.96|P-value:3.71E-10 ID:SGTC_1769|Compound:st044406|FD-Score:-3.31|P-value:3.25E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.97|P-value:2.07E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.48|P-value:1.60E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.34|P-value:2.80E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.09|P-value:7.02E-4 ID:SGTC_2011|Compound:4012611|FD-Score:6.12|P-value:1.27E-10 ID:SGTC_2064|Compound:5220758|FD-Score:3.20|P-value:4.68E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.16|P-value:5.35E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.88|P-value:3.11E-5 ID:SGTC_2286|Compound:7945697|FD-Score:4.17|P-value:8.07E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.15|P-value:5.71E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.78|P-value:4.59E-5 ID:SGTC_2315|Compound:7733312|FD-Score:3.86|P-value:3.29E-5 ID:SGTC_2341|Compound:7987486|FD-Score:-3.06|P-value:8.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.77|P-value:4.92E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.35|P-value:2.70E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:5.14|P-value:5.35E-8 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.67|P-value:2.38E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.49|P-value:1.56E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.37|P-value:2.58E-4 ID:SGTC_2819|Compound:7996655|FD-Score:6.04|P-value:2.12E-10 ID:SGTC_2822|Compound:7994718|FD-Score:3.79|P-value:4.42E-5 ID:SGTC_2828|Compound:7998861|FD-Score:-4.44|P-value:2.27E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.51|P-value:1.49E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.92|P-value:2.49E-5 ID:SGTC_2924|Compound:9010168|FD-Score:5.18|P-value:4.26E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.36|P-value:2.65E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.40|P-value:2.65E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.14|P-value:5.84E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.15|P-value:8.76E-6

Top fitness defect scores for YKR055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_587 k089-0003 6.16 57.0 µM 9.78E-11 2 3.66E-10
2 SGTC_2011 4012611 6.12 177.0 µM 1.27E-10 mitochondrial processes 6 4.68E-10
3 SGTC_2819 7996655 6.04 46.4 µM 2.12E-10 4 7.56E-10
4 SGTC_1676 st018489 5.96 23.4 µM 3.71E-10 60S ribosome export 4 1.28E-9
5 SGTC_2725 haloperidol 5.67 53.2 µM 2.38E-9 plasma membrane duress 22 7.33E-9
6 SGTC_1178 0988-0033 5.49 191.0 µM 6.98E-9 8 2.01E-8
7 SGTC_674 0498-0004 5.39 451.0 µM 1.24E-8 heme requiring 6 3.44E-8
8 SGTC_2924 9010168 5.18 62.8 µM 4.26E-8 cell wall signaling 14 1.10E-7
9 SGTC_2723 salbutamol 5.14 83.6 µM 5.35E-8 2 1.36E-7
10 SGTC_670 4204-0025 4.74 119.0 µM 4.87E-7 copper-dependent oxidative stress 17 1.08E-6
11 SGTC_1181 1222-0449 4.42 220.0 µM 2.42E-6 18 4.87E-6
12 SGTC_1124 fisetin 4.41 1.2 µM 2.54E-6 23 5.11E-6
13 SGTC_3029 9088683 4.40 49.5 µM 2.65E-6 17 5.30E-6
14 SGTC_14 0354-0009 4.27 295.0 µM 5.10E-6 25 9.82E-6
15 SGTC_2286 7945697 4.17 125.0 µM 8.07E-6 50 1.51E-5
16 SGTC_1206 3978-0017 4.17 132.0 µM 8.24E-6 ERG2 29 1.54E-5
17 SGTC_3224 9130643 4.15 49.5 µM 8.76E-6 RPP1 & pyrimidine depletion 25 1.63E-5
18 SGTC_1557 sumaresinolic acid 4.12 42.3 µM 1.01E-5 16 1.86E-5
19 SGTC_576 1073-0113 4.08 22.7 µM 1.24E-5 redox potentiating 59 2.27E-5
20 SGTC_831 k061-1017 4.03 217.0 µM 1.54E-5 translation 59 2.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.39E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.086 5.25E-7 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.086 6.31E-7 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.084 1.01E-6 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.081 2.92E-6 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.080 3.28E-6 YDL204W RTN2 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication
0.080 3.39E-6 YDL064W UBC9 het SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
0.078 5.77E-6 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.073 2.57E-5 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.071 3.53E-5 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.070 5.10E-5 YNL335W_p DDI3_p hom Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants
0.070 5.29E-5 YHR049C-A_d YHR049C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.99E-5 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.068 8.76E-5 YCR068W ATG15 hom Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
0.066 1.42E-4 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein