YKR060W / UTP30

Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR060W / UTP30

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:4.39|P-value:1.73E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-5.27|P-value:3.52E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.47|P-value:1.29E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.44|P-value:5.92E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.32|P-value:8.86E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.50|P-value:5.02E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.31|P-value:9.11E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.39|P-value:6.92E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.58|P-value:3.64E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-4.71|P-value:4.61E-6 ID:SGTC_1911|Compound:st060208|FD-Score:3.63|P-value:3.07E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.34|P-value:8.33E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.06|P-value:6.74E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.31|P-value:9.09E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.68|P-value:2.56E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.41|P-value:6.64E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.29|P-value:9.92E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.04|P-value:7.06E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:4.39|P-value:1.73E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-5.27|P-value:3.52E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.47|P-value:1.29E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.44|P-value:5.92E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.32|P-value:8.86E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.50|P-value:5.02E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.31|P-value:9.11E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.39|P-value:6.92E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.58|P-value:3.64E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-4.71|P-value:4.61E-6 ID:SGTC_1911|Compound:st060208|FD-Score:3.63|P-value:3.07E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-3.34|P-value:8.33E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-4.06|P-value:6.74E-5 ID:SGTC_2318|Compound:6029776|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.31|P-value:9.09E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.68|P-value:2.56E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.41|P-value:6.64E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.29|P-value:9.92E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.04|P-value:7.06E-5

Top fitness defect scores for YKR060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_75 0159-0059 4.39 199.0 µM 1.73E-5 fatty acid desaturase (OLE1) 15 5.61E-6
2 SGTC_3304 9125678 4.04 46.1 µM 7.06E-5 42 2.71E-5
3 SGTC_2446 5162541 3.68 200.0 µM 2.56E-4 14 1.15E-4
4 SGTC_1911 st060208 3.63 74.3 µM 3.07E-4 44 1.41E-4
5 SGTC_1755 st041960 3.58 45.2 µM 3.64E-4 35 1.70E-4
6 SGTC_427 1354-0053 3.44 47.3 µM 5.92E-4 40 2.93E-4
7 SGTC_1752 st044819 3.39 83.0 µM 6.92E-4 39 3.48E-4
8 SGTC_2362 9071156 3.31 126.0 µM 9.09E-4 28 4.73E-4
9 SGTC_1633 st005664 3.31 67.9 µM 9.11E-4 66 4.74E-4
10 SGTC_2973 9094665 3.29 18.0 µM 9.50E-4 NEO1 54 4.97E-4
11 SGTC_144 4161-2749 3.22 112.4 µM 0.00121 DNA intercalators 39 6.49E-4
12 SGTC_148 3253-0744 3.13 288.0 µM 0.00159 49 8.81E-4
13 SGTC_3301 9125354 3.08 19.8 µM 0.00184 38 0.00104
14 SGTC_2118 5526350 3.07 200.0 µM 0.00192 42 0.00109
15 SGTC_136 0097-0015 3.05 404.5 µM 0.00202 60S ribosome export 60 0.00115
16 SGTC_1329 1447-1697 3.03 50.6 µM 0.00210 42 0.00121
17 SGTC_1038 k292-0204 3.02 154.0 µM 0.00217 44 0.00125
18 SGTC_1774 st048371 3.01 48.5 µM 0.00224 RNA processing & uracil transport 66 0.00130
19 SGTC_753 1322-0200 2.98 289.0 µM 0.00246 64 0.00144
20 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 2.96 49.5 µM 0.00259 67 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.27E-17 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.141 2.40E-16 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.134 6.29E-15 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.118 6.43E-12 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.112 7.56E-11 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.106 6.87E-10 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.099 8.31E-9 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.088 3.79E-7 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.085 9.10E-7 YKR004C ECM9 het Non-essential protein of unknown function
0.081 2.63E-6 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.081 2.67E-6 YNL158W PGA1 het Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
0.081 2.85E-6 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.080 3.19E-6 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.079 5.20E-6 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.078 6.16E-6 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels