Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKR065C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.289 | 1.05E-65 | YPL251W_d | YPL251W_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C |
0.242 | 9.00E-46 | YPL252C | YAH1 | het | Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin |
0.216 | 8.44E-37 | YDR431W_d | YDR431W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.208 | 4.47E-34 | YBR261C | TAE1 | hom | AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm |
0.151 | 1.24E-18 | YDR376W | ARH1 | het | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
0.127 | 1.86E-13 | YFL015C_d | YFL015C_d | hom | Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene |
0.123 | 7.57E-13 | YGL165C_d | YGL165C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W |
0.117 | 9.90E-12 | YLL012W | YEH1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
0.112 | 8.82E-11 | YDR096W | GIS1 | hom | Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication |
0.111 | 1.14E-10 | YDR506C | GMC1 | hom | Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein |
0.111 | 1.38E-10 | YDL049C | KNH1 | hom | Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance |
0.109 | 2.20E-10 | YKR023W_p | YKR023W_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.106 | 8.87E-10 | YPL196W | OXR1 | hom | Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes |
0.104 | 1.76E-9 | YFR018C_p | YFR018C_p | hom | Putative protein of unknown function |
0.103 | 2.43E-9 | YFR028C | CDC14 | het | Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis |