YKR066C / CCP1

Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR066C / CCP1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.07|P-value:2.32E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.81|P-value:2.44E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.21|P-value:5.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.78|P-value:7.91E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.11|P-value:9.48E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.35|P-value:3.97E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.07|P-value:2.31E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:4.91|P-value:4.39E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.10|P-value:9.64E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.92|P-value:4.33E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.95|P-value:3.63E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:7.38|P-value:6.93E-14 ID:SGTC_793|Compound:0488-0545|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.36|P-value:3.85E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.52|P-value:3.02E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.11|P-value:9.42E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.84|P-value:6.06E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.86|P-value:5.52E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.23|P-value:5.52E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.05|P-value:2.50E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.82|P-value:6.93E-7 ID:SGTC_1686|Compound:st019653|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_1688|Compound:st021091|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.48|P-value:2.53E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.18|P-value:7.30E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.36|P-value:3.88E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.50|P-value:3.23E-6 ID:SGTC_1893|Compound:st059353|FD-Score:6.06|P-value:6.16E-10 ID:SGTC_1991|Compound:st073000|FD-Score:-3.20|P-value:6.16E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.87|P-value:5.46E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.02|P-value:2.86E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.76|P-value:9.13E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.18|P-value:7.44E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.98|P-value:3.43E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.80|P-value:7.12E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.76|P-value:8.29E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.39|P-value:3.43E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.25|P-value:8.97E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.32|P-value:4.05E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.25|P-value:5.68E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.40|P-value:5.35E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.07|P-value:2.32E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.81|P-value:2.44E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:3.14|P-value:8.57E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.21|P-value:5.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.78|P-value:7.91E-5 ID:SGTC_433|Compound:pimozide|FD-Score:3.11|P-value:9.48E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.35|P-value:3.97E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.07|P-value:2.31E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:4.91|P-value:4.39E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:3.10|P-value:9.64E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.92|P-value:4.33E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.95|P-value:3.63E-7 ID:SGTC_739|Compound:1486-1183|FD-Score:7.38|P-value:6.93E-14 ID:SGTC_793|Compound:0488-0545|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.36|P-value:3.85E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.52|P-value:3.02E-6 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.11|P-value:9.42E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.68|P-value:1.16E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.84|P-value:6.06E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.86|P-value:5.52E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.23|P-value:5.52E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.05|P-value:2.50E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.82|P-value:6.93E-7 ID:SGTC_1686|Compound:st019653|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_1688|Compound:st021091|FD-Score:-3.07|P-value:9.83E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.48|P-value:2.53E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.18|P-value:7.30E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.36|P-value:3.88E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.50|P-value:3.23E-6 ID:SGTC_1893|Compound:st059353|FD-Score:6.06|P-value:6.16E-10 ID:SGTC_1991|Compound:st073000|FD-Score:-3.20|P-value:6.16E-4 ID:SGTC_2000|Compound:st075254|FD-Score:4.87|P-value:5.46E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.02|P-value:2.86E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.76|P-value:9.13E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.18|P-value:7.44E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.98|P-value:3.43E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.80|P-value:7.12E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.76|P-value:8.29E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.39|P-value:3.43E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.25|P-value:8.97E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.32|P-value:4.05E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.25|P-value:5.68E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.40|P-value:5.35E-6 ID:SGTC_3194|Compound:9111903|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.64|P-value:1.36E-4

Top fitness defect scores for YKR066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_739 1486-1183 7.38 203.0 µM 6.93E-14 1 8.03E-14
2 SGTC_1893 st059353 6.06 36.1 µM 6.16E-10 4 6.69E-10
3 SGTC_734 2023-0417 4.95 80.0 µM 3.63E-7 ergosterol biosynthesis 4 3.78E-7
4 SGTC_671 0560-0003 4.91 407.0 µM 4.39E-7 5 4.57E-7
5 SGTC_2000 st075254 4.87 36.4 µM 5.46E-7 3 5.67E-7
6 SGTC_1622 st003707 4.82 19.4 µM 6.93E-7 calcium & mitochondrial duress 18 7.19E-7
7 SGTC_2089 5281248 4.76 129.7 µM 9.13E-7 superoxide 11 9.46E-7
8 SGTC_1174 0739-0097 4.52 51.1 µM 3.02E-6 redox potentiating 16 3.11E-6
9 SGTC_1891 st059073 4.50 26.2 µM 3.23E-6 TSC3-RPN4 12 3.32E-6
10 SGTC_3190 9110366 4.40 49.5 µM 5.35E-6 7 5.49E-6
11 SGTC_1686 st019653 4.19 115.5 µM 1.37E-5 mitochondrial processes 8 1.40E-5
12 SGTC_588 3970-1144 4.07 52.9 µM 2.31E-5 27 2.34E-5
13 SGTC_68 0986-0284 4.07 82.8 µM 2.32E-5 67 2.35E-5
14 SGTC_1544 7-methoxy-4-methylcoumarin 4.05 105.0 µM 2.50E-5 14 2.54E-5
15 SGTC_2055 5235184 4.02 200.0 µM 2.86E-5 ERG2 27 2.90E-5
16 SGTC_2395 5646831 3.98 180.2 µM 3.43E-5 19 3.48E-5
17 SGTC_685 1278-0033 3.92 54.9 µM 4.33E-5 60S ribosome export 22 4.39E-5
18 SGTC_1394 3474-0001 3.86 65.7 µM 5.52E-5 endomembrane recycling 46 5.59E-5
19 SGTC_1383 3049-0032 3.84 20.7 µM 6.06E-5 60S ribosome export 21 6.13E-5
20 SGTC_2633 5,7-dihydroxyisoflavone 3.80 100.0 µM 7.12E-5 33 7.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.082 1.89E-6 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.079 4.59E-6 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.077 8.75E-6 YML107C PML39 hom Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
0.076 1.05E-5 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.01E-5 YNR072W HXT17 hom Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
0.076 9.95E-6 YER182W_p FMP10_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.22E-5 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.074 1.57E-5 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.072 2.72E-5 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.068 8.69E-5 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.067 9.84E-5 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.067 9.99E-5 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.067 1.13E-4 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.066 1.31E-4 YHR074W QNS1 het Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
0.066 1.34E-4 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm