YKR067W / GPT2

Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR067W / GPT2

Click on Significant Values for Screen Details ID:SGTC_110|Compound:0850-0284|FD-Score:-3.41|P-value:8.69E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.69|P-value:3.38E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.23|P-value:4.94E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.78|P-value:5.43E-8 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.97|P-value:1.29E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.00|P-value:1.19E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.19|P-value:8.89E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.57|P-value:1.33E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:9.11|P-value:2.71E-17 ID:SGTC_576|Compound:1073-0113|FD-Score:3.56|P-value:5.20E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.54|P-value:1.45E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.93|P-value:1.49E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.39|P-value:9.06E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.45|P-value:7.45E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.84|P-value:2.02E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.43|P-value:8.04E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.40|P-value:2.57E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.57|P-value:1.29E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:3.67|P-value:3.70E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.79|P-value:2.50E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.81|P-value:1.91E-10 ID:SGTC_859|Compound:0439-0102|FD-Score:3.66|P-value:3.83E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.39|P-value:2.74E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.42|P-value:8.23E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.46|P-value:2.03E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.23|P-value:4.96E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:5.23|P-value:7.52E-7 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.71|P-value:7.47E-6 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.75|P-value:2.75E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.51|P-value:6.09E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.60|P-value:1.16E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-4.20|P-value:5.57E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.44|P-value:7.78E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:-4.09|P-value:8.67E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.67|P-value:3.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.38|P-value:9.27E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.51|P-value:1.66E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.81|P-value:2.23E-4 ID:SGTC_2882|Compound:9058044|FD-Score:5.55|P-value:1.65E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.47|P-value:7.04E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.08|P-value:8.87E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.33|P-value:3.44E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.66|P-value:3.82E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.44|P-value:7.64E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.46|P-value:7.18E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.94|P-value:1.44E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.58|P-value:4.98E-4 ID:SGTC_3263|Compound:9137018|FD-Score:4.57|P-value:1.30E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.89|P-value:3.41E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.78|P-value:2.55E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.09|P-value:8.25E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.41|P-value:8.69E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.69|P-value:3.38E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.23|P-value:4.94E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.78|P-value:5.43E-8 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.97|P-value:1.29E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.00|P-value:1.19E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.19|P-value:8.89E-7 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.57|P-value:1.33E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:9.11|P-value:2.71E-17 ID:SGTC_576|Compound:1073-0113|FD-Score:3.56|P-value:5.20E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.54|P-value:1.45E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.93|P-value:1.49E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.39|P-value:9.06E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.45|P-value:7.45E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.84|P-value:2.02E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.43|P-value:8.04E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.40|P-value:2.57E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.57|P-value:1.29E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:3.67|P-value:3.70E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.79|P-value:2.50E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.81|P-value:1.91E-10 ID:SGTC_859|Compound:0439-0102|FD-Score:3.66|P-value:3.83E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.39|P-value:2.74E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.42|P-value:8.23E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.46|P-value:2.03E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.23|P-value:4.96E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:5.23|P-value:7.52E-7 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.71|P-value:7.47E-6 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.75|P-value:2.75E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.40|P-value:8.66E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.51|P-value:6.09E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.53|P-value:5.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.60|P-value:1.16E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-4.20|P-value:5.57E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.44|P-value:7.78E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:-4.09|P-value:8.67E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.67|P-value:3.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.38|P-value:9.27E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.51|P-value:1.66E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.81|P-value:2.23E-4 ID:SGTC_2882|Compound:9058044|FD-Score:5.55|P-value:1.65E-7 ID:SGTC_2907|Compound:7721985|FD-Score:3.47|P-value:7.04E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.08|P-value:8.87E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.33|P-value:3.44E-5 ID:SGTC_3077|Compound:9117319|FD-Score:3.66|P-value:3.82E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.44|P-value:7.64E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.46|P-value:7.18E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.94|P-value:1.44E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.58|P-value:4.98E-4 ID:SGTC_3263|Compound:9137018|FD-Score:4.57|P-value:1.30E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.89|P-value:3.41E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.78|P-value:2.55E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.09|P-value:8.25E-5

Top fitness defect scores for YKR067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_545 4218-0007 9.11 221.0 µM 2.71E-17 3 4.27E-20
2 SGTC_805 3852-0218 6.81 479.0 µM 1.91E-10 ERAD & cell cycle 17 5.03E-12
3 SGTC_2882 9058044 5.55 58.4 µM 1.65E-7 4 1.44E-8
4 SGTC_1149 3909-7961 5.23 23.3 µM 7.52E-7 4 8.55E-8
5 SGTC_432 NS 1619 5.19 61.3 µM 8.89E-7 8 1.04E-7
6 SGTC_3268 9137683 4.89 49.5 µM 3.41E-6 3 5.04E-7
7 SGTC_1158 4092-0494 4.71 91.8 µM 7.47E-6 9 1.27E-6
8 SGTC_1787 fluconazole 4.60 80.0 µM 1.16E-5 iron homeostasis 14 2.12E-6
9 SGTC_749 1000-0129 4.57 128.0 µM 1.29E-5 amide catabolism 9 2.40E-6
10 SGTC_3263 9137018 4.57 49.5 µM 1.30E-5 8 2.43E-6
11 SGTC_473 2-arachidonoylglycerol 4.57 10.0 µM 1.33E-5 12 2.50E-6
12 SGTC_578 3460-0051 4.54 92.0 µM 1.45E-5 5 2.76E-6
13 SGTC_2758 dehydroepiandrosterone 4.51 69.3 µM 1.66E-5 26 3.25E-6
14 SGTC_1033 k072-0102 4.46 21.3 µM 2.03E-5 60S ribosome export 10 4.10E-6
15 SGTC_747 3448-8087 4.40 38.7 µM 2.57E-5 18 5.40E-6
16 SGTC_3052 9092717 4.33 49.5 µM 3.44E-5 15 7.60E-6
17 SGTC_302 1094-0063 4.23 18.9 µM 4.94E-5 7 1.16E-5
18 SGTC_1052 3253-3998 4.23 198.0 µM 4.96E-5 11 1.17E-5
19 SGTC_3278 9139605 4.09 49.5 µM 8.25E-5 11 2.12E-5
20 SGTC_402 epigallocatechin gallate 3.97 10.0 µM 1.29E-4 25 3.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 1.97E-9 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.098 1.37E-8 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.095 3.11E-8 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.094 5.49E-8 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.091 1.47E-7 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.088 3.39E-7 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.084 1.18E-6 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.083 1.55E-6 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.077 7.08E-6 YGL006W PMC1 hom Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
0.075 1.43E-5 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.075 1.49E-5 YGR231C PHB2 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.074 1.83E-5 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.072 3.31E-5 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.069 5.64E-5 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.069 6.29E-5 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools