YKR068C / BET3

Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR068C / BET3

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-5.91|P-value:6.84E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.47|P-value:2.59E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:5.54|P-value:7.80E-9 ID:SGTC_645|Compound:0845-0943|FD-Score:-3.31|P-value:3.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.21|P-value:4.78E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.17|P-value:6.31E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.08|P-value:1.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.05|P-value:9.54E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.10|P-value:7.91E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:7.62|P-value:3.50E-15 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.20|P-value:9.05E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.77|P-value:6.09E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.18|P-value:5.47E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.10|P-value:9.52E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.79|P-value:4.96E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.24|P-value:4.36E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.95|P-value:2.83E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.03|P-value:9.14E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.29|P-value:5.95E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.08|P-value:8.46E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.29|P-value:6.16E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.43|P-value:2.12E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.45|P-value:1.93E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.27|P-value:4.28E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.03|P-value:9.17E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.51|P-value:1.77E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.72|P-value:6.51E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.66|P-value:9.70E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.84|P-value:4.05E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.85|P-value:4.30E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.50|P-value:1.94E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.94|P-value:2.95E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.10|P-value:7.87E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.95|P-value:2.49E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.13|P-value:7.17E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.63|P-value:1.15E-6 ID:SGTC_3317|Compound:9138495|FD-Score:3.20|P-value:5.56E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.91|P-value:6.84E-10 ID:SGTC_520|Compound:3584-0023|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.47|P-value:2.59E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:5.54|P-value:7.80E-9 ID:SGTC_645|Compound:0845-0943|FD-Score:-3.31|P-value:3.35E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.21|P-value:4.78E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.17|P-value:6.31E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.08|P-value:1.57E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.05|P-value:9.54E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.10|P-value:7.91E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:7.62|P-value:3.50E-15 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.20|P-value:9.05E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.77|P-value:6.09E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.18|P-value:5.47E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.10|P-value:9.52E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.79|P-value:4.96E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.24|P-value:4.36E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.95|P-value:2.83E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.03|P-value:9.14E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.33|P-value:3.48E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.29|P-value:5.95E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.08|P-value:8.46E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.29|P-value:6.16E-6 ID:SGTC_2020|Compound:4017018|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.43|P-value:2.12E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.45|P-value:1.93E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.27|P-value:4.28E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.03|P-value:9.17E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.32|P-value:3.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.51|P-value:1.77E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:1.72E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.14|P-value:7.03E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.72|P-value:6.51E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.66|P-value:9.70E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.84|P-value:4.05E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.85|P-value:4.30E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.50|P-value:1.94E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.94|P-value:2.95E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.10|P-value:7.87E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.95|P-value:2.49E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.13|P-value:7.17E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.63|P-value:1.15E-6 ID:SGTC_3317|Compound:9138495|FD-Score:3.20|P-value:5.56E-4

Top fitness defect scores for YKR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1245 0418-0076 7.62 17.2 µM 3.50E-15 ERG2 2 1.25E-14 2.22
2 SGTC_579 4491-1009 5.54 110.0 µM 7.80E-9 60S ribosome export 3 1.50E-8 0.63
3 SGTC_1326 1431-2094 5.10 10.8 µM 9.52E-8 tubulin folding & SWR complex 1 1.65E-7 0.54
4 SGTC_3188 9110789 4.63 49.5 µM 1.15E-6 iron homeostasis 8 1.81E-6 0.30
5 SGTC_530 4358-1714 4.47 28.0 µM 2.59E-6 2 3.93E-6 0.36
6 SGTC_1501 4491-0275 4.29 38.4 µM 5.95E-6 2 8.74E-6 0.51
7 SGTC_1860 st056228 4.29 74.6 µM 6.16E-6 3 9.05E-6 0.02
8 SGTC_1251 0490-5699 4.20 265.0 µM 9.05E-6 7 1.31E-5 0.27
9 SGTC_930 2810-3379 4.08 265.0 µM 1.57E-5 3 2.22E-5 0.18
10 SGTC_1402 3909-7673 3.95 35.9 µM 2.83E-5 2 3.91E-5 0.26
11 SGTC_2769 toremifene 3.94 3.7 µM 2.95E-5 6 4.06E-5 0.01
12 SGTC_2589 lobaric acid 3.85 100.0 µM 4.30E-5 3 5.84E-5 0.51
13 SGTC_1268 0828-0275 3.77 2.5 µM 6.09E-5 6 8.16E-5 0.11
14 SGTC_2482 5981709 3.66 142.7 µM 9.70E-5 PDR1 16 1.28E-4 0.06
15 SGTC_520 3584-0023 3.55 682.0 µM 1.46E-4 17 1.89E-4 0.04
16 SGTC_2321 7390090 3.51 138.8 µM 1.72E-4 9 2.21E-4 0.21
17 SGTC_2316 5844804 3.51 197.4 µM 1.77E-4 15 2.27E-4 0.00
18 SGTC_2604 4'-hydroxychalcone 3.50 11.3 µM 1.82E-4 19 2.34E-4 0.23
19 SGTC_2020 4017018 3.49 200.0 µM 1.88E-4 11 2.40E-4 0.08
20 SGTC_2068 5226020 3.49 147.0 µM 1.89E-4 11 2.42E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.36E-11 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.109 2.58E-10 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.101 4.80E-9 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.096 2.59E-8 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.094 5.02E-8 YPR068C HOS1 hom Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.093 6.25E-8 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.093 7.70E-8 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.091 1.25E-7 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.089 2.49E-7 YNL091W NST1 hom Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
0.088 2.99E-7 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.085 8.59E-7 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.079 4.36E-6 YGR290W_d YGR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
0.079 4.76E-6 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.077 8.35E-6 YER093C-A AIM11 hom Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.074 1.93E-5 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA