YKR070W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR070W / YKR070W

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.26|P-value:8.09E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.84|P-value:9.84E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.27|P-value:7.78E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.09|P-value:2.70E-5 ID:SGTC_277|Compound:nystatin|FD-Score:3.39|P-value:3.98E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.67|P-value:2.85E-6 ID:SGTC_456|Compound:gingerol|FD-Score:-3.94|P-value:6.70E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.82|P-value:8.05E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.44|P-value:4.28E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.30|P-value:7.03E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.93|P-value:5.25E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.74|P-value:1.09E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.12|P-value:3.24E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.15|P-value:9.23E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.19|P-value:1.82E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-4.34|P-value:1.27E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.11|P-value:2.56E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-4.18|P-value:2.54E-5 ID:SGTC_1792|Compound:st045773|FD-Score:6.89|P-value:6.30E-12 ID:SGTC_1827|Compound:berberine|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-4.06|P-value:4.09E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.40|P-value:5.05E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.17|P-value:1.80E-7 ID:SGTC_2267|Compound:7931562|FD-Score:-3.43|P-value:4.52E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.17|P-value:8.68E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.23|P-value:6.92E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.56|P-value:3.54E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.20|P-value:1.71E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.78|P-value:1.21E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.22|P-value:2.10E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.78|P-value:6.45E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.80|P-value:1.58E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:5.12|P-value:2.28E-7 ID:SGTC_2796|Compound:7949634|FD-Score:3.24|P-value:6.74E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.63|P-value:2.17E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.14|P-value:2.18E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.90|P-value:5.93E-5 ID:SGTC_2977|Compound:9011197|FD-Score:-3.59|P-value:2.50E-4 ID:SGTC_2983|Compound:9022671|FD-Score:8.22|P-value:3.27E-16 ID:SGTC_2985|Compound:9022375|FD-Score:6.17|P-value:6.49E-10 ID:SGTC_3000|Compound:9075062|FD-Score:4.03|P-value:3.43E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.76|P-value:1.04E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.26|P-value:8.09E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.84|P-value:9.84E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.27|P-value:7.78E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.09|P-value:2.70E-5 ID:SGTC_277|Compound:nystatin|FD-Score:3.39|P-value:3.98E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.67|P-value:2.85E-6 ID:SGTC_456|Compound:gingerol|FD-Score:-3.94|P-value:6.70E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.82|P-value:8.05E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.44|P-value:4.28E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.30|P-value:7.03E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.93|P-value:5.25E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.74|P-value:1.09E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.12|P-value:3.24E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.15|P-value:9.23E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.19|P-value:1.82E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:-4.34|P-value:1.27E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.11|P-value:2.56E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.75|P-value:1.45E-6 ID:SGTC_1613|Compound:st002381|FD-Score:-4.18|P-value:2.54E-5 ID:SGTC_1792|Compound:st045773|FD-Score:6.89|P-value:6.30E-12 ID:SGTC_1827|Compound:berberine|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-4.06|P-value:4.09E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.40|P-value:5.05E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.17|P-value:1.80E-7 ID:SGTC_2267|Compound:7931562|FD-Score:-3.43|P-value:4.52E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.58|P-value:2.01E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.17|P-value:8.68E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.23|P-value:6.92E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.56|P-value:3.54E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.20|P-value:1.71E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.78|P-value:1.21E-6 ID:SGTC_2623|Compound:humulene|FD-Score:-4.22|P-value:2.10E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.78|P-value:6.45E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.80|P-value:1.58E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:5.12|P-value:2.28E-7 ID:SGTC_2796|Compound:7949634|FD-Score:3.24|P-value:6.74E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.63|P-value:2.17E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.14|P-value:2.18E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.59|P-value:1.95E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.90|P-value:5.93E-5 ID:SGTC_2977|Compound:9011197|FD-Score:-3.59|P-value:2.50E-4 ID:SGTC_2983|Compound:9022671|FD-Score:8.22|P-value:3.27E-16 ID:SGTC_2985|Compound:9022375|FD-Score:6.17|P-value:6.49E-10 ID:SGTC_3000|Compound:9075062|FD-Score:4.03|P-value:3.43E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.76|P-value:1.04E-4

Top fitness defect scores for YKR070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2983 9022671 8.22 13.0 µM 3.27E-16 60S ribosome export 1 9.91E-17
2 SGTC_1792 st045773 6.89 43.6 µM 6.30E-12 3 2.82E-12
3 SGTC_2985 9022375 6.17 71.4 µM 6.49E-10 RPP1 & pyrimidine depletion 5 3.47E-10
4 SGTC_2689 tacrolimus 5.78 100.0 µM 6.45E-9 11 3.76E-9
5 SGTC_2191 5911152 5.17 200.0 µM 1.80E-7 5 1.19E-7
6 SGTC_2721 ifenprodil 5.12 61.4 µM 2.28E-7 plasma membrane duress 8 1.52E-7
7 SGTC_2591 skatole 4.78 100.0 µM 1.21E-6 15 8.55E-7
8 SGTC_1605 st000082 4.75 49.1 µM 1.45E-6 60S ribosome export 4 1.04E-6
9 SGTC_2539 epi(13)torulosol 4.56 80.0 µM 3.54E-6 14 2.61E-6
10 SGTC_2564 betulinic acid 4.20 100.0 µM 1.71E-5 26 1.33E-5
11 SGTC_1518 st038567 4.19 90.8 µM 1.82E-5 10 1.42E-5
12 SGTC_2918 7977171 4.14 22.1 µM 2.18E-5 26 1.72E-5
13 SGTC_1604 st002052 4.11 72.4 µM 2.56E-5 TSC3-RPN4 23 2.02E-5
14 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.09 44.4 nM 2.70E-5 DNA damage response 28 2.13E-5
15 SGTC_1827 berberine 4.08 7.2 µM 2.78E-5 60S ribosome export 18 2.21E-5
16 SGTC_3000 9075062 4.03 71.4 µM 3.43E-5 17 2.74E-5
17 SGTC_753 1322-0200 3.93 289.0 µM 5.25E-5 19 4.25E-5
18 SGTC_2971 9092186 3.90 9.9 µM 5.93E-5 ergosterol biosynthesis 34 4.82E-5
19 SGTC_679 0422-0091 3.82 41.4 µM 8.05E-5 Golgi 34 6.61E-5
20 SGTC_3307 9126885 3.76 69.3 µM 1.04E-4 40 8.58E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.70E-13 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.118 6.91E-12 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.115 2.09E-11 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.087 4.39E-7 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.086 7.08E-7 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
0.085 9.73E-7 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.32E-6 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.081 2.60E-6 YPL072W UBP16 hom Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
0.078 6.40E-6 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.073 2.49E-5 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.070 4.80E-5 YPR114W_p YPR114W_p hom Putative protein of unknown function
0.070 5.16E-5 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.070 5.47E-5 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.069 6.72E-5 YGL185C_p YGL185C_p hom Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.069 6.90E-5 YOL153C YOL153C hom Hypothetical protein