YKR072C / SIS2

Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR072C / SIS2

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:5.93|P-value:6.92E-7 ID:SGTC_29|Compound:0299-0004|FD-Score:4.92|P-value:3.07E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.10|P-value:3.90E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.98|P-value:2.21E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.88|P-value:8.08E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.89|P-value:3.40E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.96|P-value:6.40E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.28|P-value:2.23E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.23|P-value:2.63E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.98|P-value:6.11E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-4.31|P-value:2.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.70|P-value:2.10E-25 ID:SGTC_227|Compound:fluconazole|FD-Score:4.10|P-value:4.24E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:5.22|P-value:1.08E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:4.24|P-value:2.81E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.13|P-value:3.87E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.55|P-value:3.10E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:5.14|P-value:1.43E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:5.23|P-value:1.05E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:-4.98|P-value:2.25E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.90|P-value:6.85E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:10.70|P-value:9.56E-19 ID:SGTC_902|Compound:1120-0002|FD-Score:5.76|P-value:1.39E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:-6.01|P-value:4.21E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:5.01|P-value:2.30E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.33|P-value:1.90E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.28|P-value:2.25E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.04|P-value:5.07E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.52|P-value:1.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.79|P-value:4.87E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.24|P-value:1.84E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:8.43|P-value:3.25E-12 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.34|P-value:2.11E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.34|P-value:2.06E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.00|P-value:2.35E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.97|P-value:6.20E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.06|P-value:4.80E-4 ID:SGTC_1650|Compound:st011916|FD-Score:5.17|P-value:1.30E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.21|P-value:2.13E-7 ID:SGTC_1750|Compound:st081859|FD-Score:7.54|P-value:4.03E-10 ID:SGTC_1754|Compound:st042065|FD-Score:5.67|P-value:1.98E-6 ID:SGTC_1760|Compound:st045453|FD-Score:4.03|P-value:5.23E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.98|P-value:2.50E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.40|P-value:8.18E-10 ID:SGTC_2016|Compound:5121758|FD-Score:4.27|P-value:2.60E-4 ID:SGTC_2064|Compound:5220758|FD-Score:9.82|P-value:5.98E-16 ID:SGTC_2079|Compound:5212404|FD-Score:4.90|P-value:3.32E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.42|P-value:1.63E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.70|P-value:6.63E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-8.17|P-value:1.11E-11 ID:SGTC_2192|Compound:5915882|FD-Score:6.61|P-value:3.57E-8 ID:SGTC_2197|Compound:6588183|FD-Score:-4.28|P-value:2.22E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.16|P-value:3.57E-4 ID:SGTC_2218|Compound:6965428|FD-Score:4.16|P-value:3.54E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.30|P-value:2.37E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.79|P-value:1.19E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.98|P-value:6.04E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:6.47|P-value:6.79E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:4.36|P-value:1.92E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.99|P-value:5.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.82|P-value:1.39E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.60|P-value:2.89E-10 ID:SGTC_2896|Compound:9052656|FD-Score:4.24|P-value:2.80E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.80|P-value:9.07E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.36|P-value:1.12E-7 ID:SGTC_3322|Compound:9139058|FD-Score:4.25|P-value:2.75E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.84|P-value:8.94E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:5.93|P-value:6.92E-7 ID:SGTC_29|Compound:0299-0004|FD-Score:4.92|P-value:3.07E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.10|P-value:3.90E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.98|P-value:2.21E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.88|P-value:8.08E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.89|P-value:3.40E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.96|P-value:6.40E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.28|P-value:2.23E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.23|P-value:2.63E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.98|P-value:6.11E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-4.31|P-value:2.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:12.70|P-value:2.10E-25 ID:SGTC_227|Compound:fluconazole|FD-Score:4.10|P-value:4.24E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:5.22|P-value:1.08E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:4.24|P-value:2.81E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.13|P-value:3.87E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.55|P-value:3.10E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:5.14|P-value:1.43E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:5.23|P-value:1.05E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:-4.98|P-value:2.25E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.90|P-value:6.85E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:10.70|P-value:9.56E-19 ID:SGTC_902|Compound:1120-0002|FD-Score:5.76|P-value:1.39E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:-6.01|P-value:4.21E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:5.01|P-value:2.30E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:-4.33|P-value:1.90E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.28|P-value:2.25E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.04|P-value:5.07E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.52|P-value:1.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.79|P-value:4.87E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:6.24|P-value:1.84E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:8.43|P-value:3.25E-12 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.34|P-value:2.11E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.34|P-value:2.06E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.00|P-value:2.35E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.97|P-value:6.20E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.06|P-value:4.80E-4 ID:SGTC_1650|Compound:st011916|FD-Score:5.17|P-value:1.30E-5 ID:SGTC_1745|Compound:st081495|FD-Score:6.21|P-value:2.13E-7 ID:SGTC_1750|Compound:st081859|FD-Score:7.54|P-value:4.03E-10 ID:SGTC_1754|Compound:st042065|FD-Score:5.67|P-value:1.98E-6 ID:SGTC_1760|Compound:st045453|FD-Score:4.03|P-value:5.23E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.98|P-value:2.50E-5 ID:SGTC_1803|Compound:st050068|FD-Score:7.40|P-value:8.18E-10 ID:SGTC_2016|Compound:5121758|FD-Score:4.27|P-value:2.60E-4 ID:SGTC_2064|Compound:5220758|FD-Score:9.82|P-value:5.98E-16 ID:SGTC_2079|Compound:5212404|FD-Score:4.90|P-value:3.32E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.42|P-value:1.63E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.70|P-value:6.63E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-8.17|P-value:1.11E-11 ID:SGTC_2192|Compound:5915882|FD-Score:6.61|P-value:3.57E-8 ID:SGTC_2197|Compound:6588183|FD-Score:-4.28|P-value:2.22E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.16|P-value:3.57E-4 ID:SGTC_2218|Compound:6965428|FD-Score:4.16|P-value:3.54E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.30|P-value:2.37E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.79|P-value:1.19E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.98|P-value:6.04E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:6.47|P-value:6.79E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:4.36|P-value:1.92E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.99|P-value:5.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.82|P-value:1.39E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.60|P-value:2.89E-10 ID:SGTC_2896|Compound:9052656|FD-Score:4.24|P-value:2.80E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.80|P-value:9.07E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.36|P-value:1.12E-7 ID:SGTC_3322|Compound:9139058|FD-Score:4.25|P-value:2.75E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.84|P-value:8.94E-4

Top fitness defect scores for YKR072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 12.70 10.3 µM 2.10E-25 NEO1-PIK1 34 3.40E-37
2 SGTC_900 1112-0045 10.70 141.0 µM 9.56E-19 NEO1 2 3.11E-27
3 SGTC_2064 5220758 9.82 200.0 µM 5.98E-16 1 4.71E-23
4 SGTC_1129 3453-1384 8.43 223.0 µM 3.25E-12 2 1.78E-17
5 SGTC_2651 1327-0036 7.60 5.0 µM 2.89E-10 41 1.44E-14
6 SGTC_1750 st081859 7.54 2.4 µM 4.03E-10 endomembrane recycling 79 2.36E-14
7 SGTC_1803 st050068 7.40 52.4 µM 8.18E-10 NEO1-PIK1 49 6.78E-14
8 SGTC_2582 agaric acid 6.82 100.0 µM 1.39E-8 redox potentiating 134 4.62E-12
9 SGTC_2192 5915882 6.61 198.5 µM 3.57E-8 RNA processing & uracil transport 9 1.88E-11
10 SGTC_2522 biochanin a 6.47 4.9 µM 6.79E-8 RNA pol III & RNase P/MRP 2 4.88E-11
11 SGTC_3311 9131146 6.36 2.9 µM 1.12E-7 cell wall 55 1.02E-10
12 SGTC_1128 3448-9350 6.24 235.0 µM 1.84E-7 4 2.14E-10
13 SGTC_1745 st081495 6.21 74.0 µM 2.13E-7 RNA processing & uracil transport 24 2.68E-10
14 SGTC_20 0481-0013 5.93 4.9 µM 6.92E-7 5 1.54E-9
15 SGTC_2342 7990637 5.79 118.9 µM 1.19E-6 RNA processing & uracil transport 5 3.45E-9
16 SGTC_902 1120-0002 5.76 2.1 µM 1.39E-6 azole & statin 20 4.31E-9
17 SGTC_1754 st042065 5.67 16.1 µM 1.98E-6 NEO1-PIK1 105 7.33E-9
18 SGTC_629 3448-6466 5.55 76.7 µM 3.10E-6 2 1.42E-8
19 SGTC_871 0574-0004 5.23 149.0 µM 1.05E-5 19 8.63E-8
20 SGTC_558 k064-0027 5.22 21.3 µM 1.08E-5 DNA damage response 11 9.02E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.285 1.50E-63 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.279 4.94E-61 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.228 6.90E-41 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.228 8.53E-41 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.223 4.72E-39 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.220 6.96E-38 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.214 6.27E-36 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.208 3.23E-34 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.208 4.24E-34 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.208 4.40E-34 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.207 8.89E-34 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.205 4.01E-33 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.201 5.44E-32 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.193 1.60E-29 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.192 2.74E-29 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress