YKR073C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR073C / YKR073C

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:4.32|P-value:2.71E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.29|P-value:3.01E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.46|P-value:6.46E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.08|P-value:6.87E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.49|P-value:1.32E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.56|P-value:4.58E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:6.73|P-value:1.26E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:3.54|P-value:4.84E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:7.68|P-value:2.52E-13 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:5.38E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.49|P-value:7.80E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.98|P-value:1.57E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.13|P-value:5.82E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.41|P-value:4.86E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.01|P-value:9.03E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:5.22|P-value:4.89E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.88|P-value:1.50E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.52|P-value:5.18E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.77|P-value:2.21E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.83|P-value:1.78E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.69|P-value:1.61E-10 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.89|P-value:1.44E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.33|P-value:6.30E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.46|P-value:4.09E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.58|P-value:4.31E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.26|P-value:8.03E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.26|P-value:3.37E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.39|P-value:2.07E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.56|P-value:4.50E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.02|P-value:8.76E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:3.33E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:6.70|P-value:1.54E-10 ID:SGTC_1626|Compound:st003712|FD-Score:3.53|P-value:4.98E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.85|P-value:1.01E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.65|P-value:3.32E-4 ID:SGTC_1745|Compound:st081495|FD-Score:9.50|P-value:1.76E-19 ID:SGTC_1750|Compound:st081859|FD-Score:6.11|P-value:4.81E-9 ID:SGTC_1754|Compound:st042065|FD-Score:11.50|P-value:6.34E-28 ID:SGTC_1760|Compound:st045453|FD-Score:5.26|P-value:4.11E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.16|P-value:5.04E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.24|P-value:4.26E-15 ID:SGTC_1818|Compound:st052136|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.17|P-value:4.82E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.44|P-value:4.41E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.86|P-value:1.61E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.64|P-value:7.10E-6 ID:SGTC_2526|Compound:patulin|FD-Score:-3.54|P-value:3.14E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:6.68E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.56|P-value:4.49E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.70|P-value:2.18E-29 ID:SGTC_2623|Compound:humulene|FD-Score:3.48|P-value:6.05E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.60|P-value:7.36E-8 ID:SGTC_2877|Compound:9040724|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.73|P-value:4.75E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.70|P-value:5.40E-6 ID:SGTC_2985|Compound:9022375|FD-Score:4.67|P-value:6.09E-6 ID:SGTC_3178|Compound:9107506|FD-Score:-4.06|P-value:4.62E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.68|P-value:3.06E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.30|P-value:2.98E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:4.32|P-value:2.71E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.93|P-value:1.24E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.29|P-value:3.01E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.46|P-value:6.46E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.08|P-value:6.87E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:4.49|P-value:1.32E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.56|P-value:4.58E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:6.73|P-value:1.26E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:3.54|P-value:4.84E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.61|P-value:2.40E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:7.68|P-value:2.52E-13 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:5.38E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.49|P-value:7.80E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.98|P-value:1.57E-6 ID:SGTC_843|Compound:0310-0051|FD-Score:4.13|P-value:5.82E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.41|P-value:4.86E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.01|P-value:9.03E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:4.49|P-value:1.33E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:5.22|P-value:4.89E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.88|P-value:1.50E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.52|P-value:5.18E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.77|P-value:2.21E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.83|P-value:1.78E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.86|P-value:1.56E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.69|P-value:1.61E-10 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.89|P-value:1.44E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.33|P-value:6.30E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.46|P-value:4.09E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.58|P-value:4.31E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.26|P-value:8.03E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.26|P-value:3.37E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.39|P-value:2.07E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.56|P-value:4.50E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.02|P-value:8.76E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:3.33E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:6.70|P-value:1.54E-10 ID:SGTC_1626|Compound:st003712|FD-Score:3.53|P-value:4.98E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.85|P-value:1.01E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.65|P-value:3.32E-4 ID:SGTC_1745|Compound:st081495|FD-Score:9.50|P-value:1.76E-19 ID:SGTC_1750|Compound:st081859|FD-Score:6.11|P-value:4.81E-9 ID:SGTC_1754|Compound:st042065|FD-Score:11.50|P-value:6.34E-28 ID:SGTC_1760|Compound:st045453|FD-Score:5.26|P-value:4.11E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.16|P-value:5.04E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.24|P-value:4.26E-15 ID:SGTC_1818|Compound:st052136|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.17|P-value:4.82E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.44|P-value:4.41E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.86|P-value:1.61E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.55|P-value:1.02E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.64|P-value:7.10E-6 ID:SGTC_2526|Compound:patulin|FD-Score:-3.54|P-value:3.14E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:6.68E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.56|P-value:4.49E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-11.70|P-value:2.18E-29 ID:SGTC_2623|Compound:humulene|FD-Score:3.48|P-value:6.05E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.60|P-value:7.36E-8 ID:SGTC_2877|Compound:9040724|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.73|P-value:4.75E-6 ID:SGTC_2928|Compound:9011484|FD-Score:4.70|P-value:5.40E-6 ID:SGTC_2985|Compound:9022375|FD-Score:4.67|P-value:6.09E-6 ID:SGTC_3178|Compound:9107506|FD-Score:-4.06|P-value:4.62E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.68|P-value:3.06E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.30|P-value:2.98E-5

Top fitness defect scores for YKR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1754 st042065 11.50 16.1 µM 6.34E-28 NEO1-PIK1 15 4.06E-31
2 SGTC_1745 st081495 9.50 74.0 µM 1.76E-19 RNA processing & uracil transport 8 1.08E-21
3 SGTC_1803 st050068 8.24 52.4 µM 4.26E-15 NEO1-PIK1 37 8.47E-17
4 SGTC_577 r071-0003 7.68 38.6 µM 2.52E-13 fatty acid desaturase (OLE1) 5 8.09E-15
5 SGTC_403 arphamenine a 6.73 50.0 µM 1.26E-10 60S ribosome export 2 8.44E-12
6 SGTC_1596 piperlongumine 6.70 63.0 µM 1.54E-10 2 1.06E-11
7 SGTC_1202 1988-0068 6.69 29.6 µM 1.61E-10 RNA processing & uracil transport 5 1.11E-11
8 SGTC_1750 st081859 6.11 2.4 µM 4.81E-9 endomembrane recycling 106 4.96E-10
9 SGTC_2651 1327-0036 5.60 5.0 µM 7.36E-8 84 1.05E-8
10 SGTC_1760 st045453 5.26 10.4 µM 4.11E-7 NEO1-PIK1 101 7.19E-8
11 SGTC_955 1216-0110 5.22 33.0 µM 4.89E-7 sphingolipid biosynthesis & PDR1 43 8.73E-8
12 SGTC_788 1182-0090 4.98 188.0 µM 1.57E-6 endomembrane recycling 52 3.22E-7
13 SGTC_2902 5787006 4.73 60.5 µM 4.75E-6 Golgi 15 1.12E-6
14 SGTC_682 0kpi-0099 4.70 17.0 µM 5.38E-6 44 1.28E-6
15 SGTC_2928 9011484 4.70 9.8 µM 5.40E-6 heme biosynthesis & mitochondrial translocase 24 1.29E-6
16 SGTC_2985 9022375 4.67 71.4 µM 6.09E-6 RPP1 & pyrimidine depletion 16 1.47E-6
17 SGTC_2522 biochanin a 4.64 4.9 µM 7.10E-6 RNA pol III & RNase P/MRP 5 1.75E-6
18 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.55 54.6 µM 1.02E-5 RPP1 & pyrimidine depletion 19 2.62E-6
19 SGTC_347 4534-1311 4.49 26.2 µM 1.32E-5 RPP1 & pyrimidine depletion 7 3.52E-6
20 SGTC_923 1900-2434 4.49 73.3 µM 1.33E-5 RNA processing & uracil transport 21 3.54E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 1.89E-63 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.259 1.79E-52 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.240 4.43E-45 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.229 2.64E-41 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.226 4.66E-40 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.220 6.33E-38 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.211 5.97E-35 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.209 2.16E-34 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208 3.23E-34 YKR072C SIS2 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.199 2.26E-31 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.196 1.81E-30 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.192 3.64E-29 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.188 4.94E-28 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.187 6.49E-28 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.186 2.13E-27 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity