HIPHOP chemogenomics database
YKR074W / AIM29 
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKR074W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.126 | 2.62E-13 | YLR141W | RRN5 | het | Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p |
| 0.098 | 1.12E-8 | YJL195C_d | YJL195C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 |
| 0.094 | 5.02E-8 | YML002W_p | YML002W_p | hom | Putative protein of unknown function; expression induced by heat and by calcium shortage |
| 0.087 | 5.07E-7 | YOR174W | MED4 | het | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
| 0.085 | 8.27E-7 | YER113C | TMN3 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation |
| 0.083 | 1.40E-6 | YLR061W | RPL22A | hom | Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication |
| 0.081 | 2.83E-6 | YBL032W | HEK2 | hom | RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K |
| 0.080 | 3.67E-6 | YOR309C_d | YOR309C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 |
| 0.079 | 4.81E-6 | YFR017C | IGD1 | hom | Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication |
| 0.079 | 4.97E-6 | YDL072C | YET3 | hom | Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress |
| 0.076 | 1.09E-5 | YDL155W | CLB3 | hom | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress |
| 0.075 | 1.29E-5 | YNL066W | SUN4 | hom | Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family |
| 0.075 | 1.35E-5 | YIL088C | AVT7 | hom | Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
| 0.074 | 1.70E-5 | YNL110C | NOP15 | het | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm |
| 0.072 | 2.99E-5 | YKL096W | CWP1 | hom | Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance |