YKR074W / AIM29

Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR074W / AIM29

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.62|P-value:2.72E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.63|P-value:1.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.76|P-value:9.77E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.63|P-value:2.46E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.28|P-value:3.37E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:4.56|P-value:3.42E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:4.79E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.53|P-value:3.82E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:2.99E-5 ID:SGTC_458|Compound:nppb|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.27|P-value:1.24E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.24|P-value:6.43E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.36|P-value:4.32E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:2.54E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.23|P-value:6.65E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.88|P-value:6.14E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.49|P-value:4.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.75|P-value:1.38E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.52|P-value:2.47E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.21|P-value:7.32E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.35|P-value:4.44E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.99|P-value:3.97E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.34|P-value:7.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.94|P-value:5.60E-7 ID:SGTC_1683|Compound:st010134|FD-Score:6.52|P-value:7.52E-11 ID:SGTC_1685|Compound:st024049|FD-Score:4.16|P-value:2.00E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.45|P-value:5.60E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.90|P-value:5.79E-5 ID:SGTC_2000|Compound:st075254|FD-Score:4.12|P-value:2.33E-5 ID:SGTC_2019|Compound:4016004|FD-Score:6.88|P-value:7.03E-12 ID:SGTC_2066|Compound:5222451|FD-Score:4.43|P-value:6.25E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.44|P-value:5.09E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.84|P-value:1.63E-6 ID:SGTC_2174|Compound:5790901|FD-Score:4.47|P-value:5.18E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.55|P-value:3.57E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.81|P-value:8.04E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_2352|Compound:9027995|FD-Score:5.19|P-value:1.62E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.23|P-value:2.53E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.78|P-value:1.22E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.19|P-value:1.77E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.54|P-value:3.54E-4 ID:SGTC_2800|Compound:7887935|FD-Score:6.78|P-value:1.40E-11 ID:SGTC_2816|Compound:7982706|FD-Score:-4.30|P-value:1.83E-5 ID:SGTC_2819|Compound:7996655|FD-Score:6.40|P-value:1.54E-10 ID:SGTC_2826|Compound:7992541|FD-Score:-4.12|P-value:3.92E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-5.57|P-value:4.08E-8 ID:SGTC_2828|Compound:7998861|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.68|P-value:1.92E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.79|P-value:8.69E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.54|P-value:2.24E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.27|P-value:5.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.62|P-value:2.72E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.37|P-value:4.11E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.63|P-value:1.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.76|P-value:9.77E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.63|P-value:2.46E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.28|P-value:3.37E-10 ID:SGTC_211|Compound:3455-0679|FD-Score:4.56|P-value:3.42E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.33|P-value:4.79E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.53|P-value:3.82E-6 ID:SGTC_394|Compound:menadione|FD-Score:3.58|P-value:1.97E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:2.99E-5 ID:SGTC_458|Compound:nppb|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.27|P-value:1.24E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.24|P-value:6.43E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.36|P-value:4.32E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:2.54E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.23|P-value:6.65E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.88|P-value:6.14E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.49|P-value:4.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.75|P-value:1.38E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.52|P-value:2.47E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.21|P-value:7.32E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.08|P-value:2.78E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.35|P-value:4.44E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.99|P-value:3.97E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.34|P-value:7.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.94|P-value:5.60E-7 ID:SGTC_1683|Compound:st010134|FD-Score:6.52|P-value:7.52E-11 ID:SGTC_1685|Compound:st024049|FD-Score:4.16|P-value:2.00E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.45|P-value:5.60E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.90|P-value:5.79E-5 ID:SGTC_2000|Compound:st075254|FD-Score:4.12|P-value:2.33E-5 ID:SGTC_2019|Compound:4016004|FD-Score:6.88|P-value:7.03E-12 ID:SGTC_2066|Compound:5222451|FD-Score:4.43|P-value:6.25E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.44|P-value:5.09E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-4.84|P-value:1.63E-6 ID:SGTC_2174|Compound:5790901|FD-Score:4.47|P-value:5.18E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.55|P-value:3.57E-6 ID:SGTC_2277|Compound:7947813|FD-Score:3.81|P-value:8.04E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_2352|Compound:9027995|FD-Score:5.19|P-value:1.62E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.86|P-value:6.78E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.23|P-value:2.53E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.78|P-value:1.22E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.19|P-value:1.77E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.54|P-value:3.54E-4 ID:SGTC_2800|Compound:7887935|FD-Score:6.78|P-value:1.40E-11 ID:SGTC_2816|Compound:7982706|FD-Score:-4.30|P-value:1.83E-5 ID:SGTC_2819|Compound:7996655|FD-Score:6.40|P-value:1.54E-10 ID:SGTC_2826|Compound:7992541|FD-Score:-4.12|P-value:3.92E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-5.57|P-value:4.08E-8 ID:SGTC_2828|Compound:7998861|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.68|P-value:1.92E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.79|P-value:8.69E-5 ID:SGTC_3114|Compound:9122766|FD-Score:3.54|P-value:2.24E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.27|P-value:5.90E-4

Top fitness defect scores for YKR074W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2019 4016004 6.88 108.0 µM 7.03E-12 1 3.01E-12
2 SGTC_2800 7887935 6.78 81.8 µM 1.40E-11 RPP1 & pyrimidine depletion 2 6.20E-12
3 SGTC_1683 st010134 6.52 710.0 nM 7.52E-11 2 3.58E-11
4 SGTC_2819 7996655 6.40 46.4 µM 1.54E-10 2 7.54E-11
5 SGTC_182 3448-4371 6.28 550.5 µM 3.37E-10 5 1.71E-10
6 SGTC_2352 9027995 5.19 87.8 µM 1.62E-7 tubulin folding & SWR complex 16 1.07E-7
7 SGTC_1676 st018489 4.94 23.4 µM 5.60E-7 60S ribosome export 13 3.91E-7
8 SGTC_2614 arthonioic acid 4.78 13.4 µM 1.22E-6 11 8.81E-7
9 SGTC_1084 voriconazole 4.75 435.0 nM 1.38E-6 azole & statin 14 1.00E-6
10 SGTC_2939 9044578 4.68 71.4 µM 1.92E-6 28 1.41E-6
11 SGTC_118 0083-0097 4.63 135.3 µM 2.46E-6 translation 78 1.82E-6
12 SGTC_211 3455-0679 4.56 143.5 µM 3.42E-6 10 2.57E-6
13 SGTC_2266 7929956 4.55 200.0 µM 3.57E-6 16 2.69E-6
14 SGTC_227 fluconazole 4.53 33.5 µM 3.82E-6 azole & statin 62 2.89E-6
15 SGTC_2174 5790901 4.47 200.0 µM 5.18E-6 tubulin folding & SWR complex 30 3.96E-6
16 SGTC_1975 st070967 4.45 30.8 µM 5.60E-6 25 4.30E-6
17 SGTC_2066 5222451 4.43 176.0 µM 6.25E-6 heme biosynthesis & mitochondrial translocase 21 4.81E-6
18 SGTC_520 3584-0023 4.27 682.0 µM 1.24E-5 20 9.79E-6
19 SGTC_458 nppb 4.21 133.0 µM 1.62E-5 12 1.29E-5
20 SGTC_2617 dihydrotanshinone i 4.19 20.8 µM 1.77E-5 copper-dependent oxidative stress 36 1.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.62E-13 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.098 1.12E-8 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.094 5.02E-8 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.087 5.07E-7 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.085 8.27E-7 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.083 1.40E-6 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.081 2.83E-6 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.080 3.67E-6 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.079 4.81E-6 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.079 4.97E-6 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.076 1.09E-5 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.075 1.29E-5 YNL066W SUN4 hom Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
0.075 1.35E-5 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.074 1.70E-5 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.072 2.99E-5 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance