YKR075C_p

Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR075C / YKR075C

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:5.23|P-value:2.58E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:6.29|P-value:8.05E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:3.68|P-value:2.03E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:5.08|P-value:5.47E-7 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.23|P-value:9.50E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.78|P-value:1.56E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.56|P-value:3.16E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.30|P-value:7.58E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.82|P-value:1.89E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.79|P-value:1.37E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:4.94|P-value:1.04E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.76|P-value:1.48E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:9.37E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.44|P-value:4.64E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.68|P-value:2.05E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.66|P-value:2.19E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.78|P-value:2.22E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.23|P-value:9.48E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.75|P-value:1.56E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.44|P-value:5.23E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.27|P-value:2.02E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.35|P-value:6.39E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.44|P-value:9.84E-6 ID:SGTC_1674|Compound:st016616|FD-Score:4.40|P-value:1.19E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.07|P-value:4.70E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.48|P-value:4.64E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.92|P-value:6.59E-9 ID:SGTC_2157|Compound:5649910|FD-Score:4.65|P-value:4.01E-6 ID:SGTC_2188|Compound:6126565|FD-Score:-3.37|P-value:6.58E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.34|P-value:6.71E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.25|P-value:9.98E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.36|P-value:6.27E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.51|P-value:4.20E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.46|P-value:4.43E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.46|P-value:4.35E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.18|P-value:3.36E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.53|P-value:3.46E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.51|P-value:3.72E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.56|P-value:3.13E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:5.23|P-value:2.58E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:6.29|P-value:8.05E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:3.68|P-value:2.03E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.26|P-value:8.72E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:5.08|P-value:5.47E-7 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.23|P-value:9.50E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.78|P-value:1.56E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.56|P-value:3.16E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.30|P-value:7.58E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.82|P-value:1.89E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:3.79|P-value:1.37E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:4.94|P-value:1.04E-6 ID:SGTC_820|Compound:1582-0060|FD-Score:3.76|P-value:1.48E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:9.37E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.44|P-value:4.64E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.68|P-value:2.05E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.66|P-value:2.19E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.78|P-value:2.22E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.23|P-value:9.48E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.75|P-value:1.56E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.44|P-value:5.23E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.27|P-value:2.02E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.35|P-value:6.39E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.44|P-value:9.84E-6 ID:SGTC_1674|Compound:st016616|FD-Score:4.40|P-value:1.19E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.07|P-value:4.70E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.24|P-value:9.21E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.48|P-value:4.64E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.92|P-value:6.59E-9 ID:SGTC_2157|Compound:5649910|FD-Score:4.65|P-value:4.01E-6 ID:SGTC_2188|Compound:6126565|FD-Score:-3.37|P-value:6.58E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.34|P-value:6.71E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.25|P-value:9.98E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.36|P-value:6.27E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-3.51|P-value:4.20E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.46|P-value:4.43E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.46|P-value:4.35E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-4.18|P-value:3.36E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.53|P-value:3.46E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.51|P-value:3.72E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.56|P-value:3.13E-4

Top fitness defect scores for YKR075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 6.29 35.0 µM 8.05E-10 calcium & mitochondrial duress 25 1.60E-10
2 SGTC_2149 5554786 5.92 194.8 µM 6.59E-9 cell wall signaling 8 1.58E-9
3 SGTC_60 0986-0278 5.23 202.0 µM 2.58E-7 1 8.48E-8
4 SGTC_166 k072-0058 5.08 166.4 µM 5.47E-7 DNA intercalators 16 1.91E-7
5 SGTC_661 1304-0007 4.94 33.6 µM 1.04E-6 7 3.86E-7
6 SGTC_652 0437-0092 4.82 114.0 µM 1.89E-6 4 7.34E-7
7 SGTC_1165 k072-0275 4.78 30.3 µM 2.22E-6 26 8.78E-7
8 SGTC_2157 5649910 4.65 96.4 µM 4.01E-6 11 1.66E-6
9 SGTC_1567 st069303 4.44 68.4 µM 9.84E-6 mitochondrial processes 8 4.40E-6
10 SGTC_164 4100-3994 4.42 89.6 µM 1.09E-5 19 4.94E-6
11 SGTC_1674 st016616 4.40 23.6 µM 1.19E-5 20 5.41E-6
12 SGTC_1362 1611-0397 4.27 101.0 µM 2.02E-5 14 9.62E-6
13 SGTC_1735 st034310 4.07 56.8 µM 4.70E-5 Golgi 23 2.40E-5
14 SGTC_655 k060-0012 3.79 42.0 µM 1.37E-4 14 7.65E-5
15 SGTC_820 1582-0060 3.76 59.9 µM 1.48E-4 37 8.34E-5
16 SGTC_1292 0kpi-0043 3.75 232.0 µM 1.56E-4 20 8.78E-5
17 SGTC_74 000s-0487 3.68 160.3 µM 2.03E-4 27 1.17E-4
18 SGTC_1049 3226-0134 3.68 66.0 µM 2.05E-4 37 1.18E-4
19 SGTC_1150 3909-7983 3.66 10.9 µM 2.19E-4 35 1.27E-4
20 SGTC_3277 9138724 3.56 49.5 µM 3.13E-4 Golgi 32 1.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.00E-12 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.109 2.32E-10 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.109 2.59E-10 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.106 7.89E-10 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.088 2.85E-7 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.088 3.22E-7 YCR019W MAK32 hom Protein necessary for structural stability of L-A double-stranded RNA-containing particles
0.087 3.98E-7 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.087 4.45E-7 YOR183W_p FYV12_p hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.086 5.60E-7 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.085 8.68E-7 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.079 4.16E-6 YML082W_p YML082W_p hom Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
0.078 5.59E-6 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.078 5.46E-6 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.078 6.69E-6 YDL161W ENT1 hom Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.078 6.76E-6 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress