YKR077W / MSA2

Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR077W / MSA2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.39|P-value:3.71E-6 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.84|P-value:4.51E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.09|P-value:8.15E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.17|P-value:6.14E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.77|P-value:5.95E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.42|P-value:3.28E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:3.30|P-value:3.77E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.06|P-value:9.06E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.65|P-value:9.65E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.85|P-value:4.34E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.74|P-value:6.65E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.13|P-value:7.11E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.06|P-value:9.00E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.68|P-value:3.32E-9 ID:SGTC_2335|Compound:9018011|FD-Score:-3.15|P-value:6.14E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.84|P-value:3.88E-7 ID:SGTC_2360|Compound:9040895|FD-Score:4.26|P-value:6.73E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.25|P-value:4.64E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.29|P-value:3.93E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.05|P-value:8.84E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.83|P-value:4.14E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.52|P-value:1.97E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.04|P-value:9.10E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.02|P-value:9.61E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.77|P-value:5.74E-7 ID:SGTC_2917|Compound:7979103|FD-Score:4.00|P-value:2.20E-5 ID:SGTC_2919|Compound:7978188|FD-Score:5.20|P-value:5.41E-8 ID:SGTC_2952|Compound:9073731|FD-Score:3.51|P-value:1.71E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.03|P-value:9.38E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.68|P-value:7.98E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-9.63|P-value:3.25E-23 ID:SGTC_3071|Compound:9117417|FD-Score:-3.05|P-value:8.89E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.95|P-value:2.58E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.05|P-value:1.80E-5 ID:SGTC_3123|Compound:9126162|FD-Score:3.38|P-value:2.81E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.31|P-value:3.47E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.61|P-value:1.16E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.23|P-value:2.14E-17 ID:SGTC_3150|Compound:9097574|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.03|P-value:1.81E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.12|P-value:7.32E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.26|P-value:4.46E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.39|P-value:3.71E-6 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.30|P-value:3.84E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.15|P-value:6.63E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.84|P-value:4.51E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.12|P-value:7.36E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.09|P-value:8.15E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.17|P-value:6.14E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.54|P-value:1.43E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.77|P-value:5.95E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.42|P-value:3.28E-6 ID:SGTC_984|Compound:1492-0255|FD-Score:3.30|P-value:3.77E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.06|P-value:9.06E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.65|P-value:9.65E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.85|P-value:4.34E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.74|P-value:6.65E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.38|P-value:2.82E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.13|P-value:7.11E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.06|P-value:9.00E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.48|P-value:1.91E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.15|P-value:6.57E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.68|P-value:3.32E-9 ID:SGTC_2335|Compound:9018011|FD-Score:-3.15|P-value:6.14E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.84|P-value:3.88E-7 ID:SGTC_2360|Compound:9040895|FD-Score:4.26|P-value:6.73E-6 ID:SGTC_2464|Compound:5717415|FD-Score:3.25|P-value:4.64E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.29|P-value:3.93E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.05|P-value:8.84E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.09|P-value:1.52E-5 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.83|P-value:4.14E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.52|P-value:1.97E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.42|P-value:2.41E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.04|P-value:9.10E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.45|P-value:2.17E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.02|P-value:9.61E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.77|P-value:5.74E-7 ID:SGTC_2917|Compound:7979103|FD-Score:4.00|P-value:2.20E-5 ID:SGTC_2919|Compound:7978188|FD-Score:5.20|P-value:5.41E-8 ID:SGTC_2952|Compound:9073731|FD-Score:3.51|P-value:1.71E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.03|P-value:9.38E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.68|P-value:7.98E-5 ID:SGTC_3068|Compound:9116768|FD-Score:-9.63|P-value:3.25E-23 ID:SGTC_3071|Compound:9117417|FD-Score:-3.05|P-value:8.89E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.95|P-value:2.58E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.05|P-value:1.80E-5 ID:SGTC_3123|Compound:9126162|FD-Score:3.38|P-value:2.81E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.31|P-value:3.47E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.61|P-value:1.16E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.23|P-value:2.14E-17 ID:SGTC_3150|Compound:9097574|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.03|P-value:1.81E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.12|P-value:7.32E-4 ID:SGTC_3288|Compound:9119690|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.26|P-value:4.46E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.60|P-value:1.21E-4

Top fitness defect scores for YKR077W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3148 9097893 8.23 49.5 µM 2.14E-17 6 9.60E-17
2 SGTC_2321 7390090 5.68 138.8 µM 3.32E-9 9 6.75E-9
3 SGTC_2919 7978188 5.20 46.4 µM 5.41E-8 6 9.80E-8
4 SGTC_2337 9009472 4.84 200.0 µM 3.88E-7 14 6.48E-7
5 SGTC_2552 juarezic acid 4.83 87.0 µM 4.14E-7 TSC3-RPN4 15 6.90E-7
6 SGTC_2887 9044784 4.77 58.4 µM 5.74E-7 fatty acid desaturase (OLE1) 13 9.43E-7
7 SGTC_1767 st044992 4.74 70.3 µM 6.65E-7 10 1.09E-6
8 SGTC_2562 3',7'-dimethoxyflavone 4.52 64.9 µM 1.97E-6 15 3.09E-6
9 SGTC_982 1491-0518 4.42 27.5 µM 3.28E-6 7 5.02E-6
10 SGTC_47 0149-0135 4.39 24.2 µM 3.71E-6 TSC3-RPN4 14 5.66E-6
11 SGTC_2360 9040895 4.26 200.0 µM 6.73E-6 RPP1 & pyrimidine depletion 12 1.00E-5
12 SGTC_2528 xanthyletin 4.09 44.8 µM 1.52E-5 21 2.18E-5
13 SGTC_3288 9119690 4.08 36.2 µM 1.58E-5 22 2.28E-5
14 SGTC_3077 9117319 4.05 49.5 µM 1.80E-5 17 2.57E-5
15 SGTC_2917 7979103 4.00 53.8 µM 2.20E-5 29 3.13E-5
16 SGTC_1601 4'-hydroxyflavanone 3.85 55.5 µM 4.34E-5 RPP1 & pyrimidine depletion 32 5.99E-5
17 SGTC_369 0957-0393 3.84 4.5 µM 4.51E-5 cell wall signaling 26 6.21E-5
18 SGTC_980 1473-0395 3.77 201.0 µM 5.95E-5 14 8.12E-5
19 SGTC_1456 k015-0012 3.65 13.0 µM 9.65E-5 42 1.29E-4
20 SGTC_3147 9097027 3.61 49.5 µM 1.16E-4 33 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.22E-8 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.091 1.29E-7 YML003W_p YML003W_p hom Putative protein of unknown function
0.084 1.12E-6 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.082 1.86E-6 YHR049C-A_d YHR049C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.05E-6 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.079 4.48E-6 YHR162W MPC2 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium
0.078 6.89E-6 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.077 8.05E-6 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.074 1.60E-5 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.073 2.22E-5 YGL190C CDC55 hom Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion
0.073 2.44E-5 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.073 2.59E-5 YIL157C COA1 hom Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly
0.072 2.63E-5 YGL162W SUT1 hom Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.071 4.05E-5 YDL024C DIA3 hom Protein of unknown function, involved in invasive and pseudohyphal growth
0.070 5.13E-5 YOR003W YSP3 hom Putative precursor to the subtilisin-like protease III