YKR079C / TRZ1

tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR079C / TRZ1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.58|P-value:3.02E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:3.63|P-value:3.89E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.05|P-value:3.90E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-2.89|P-value:7.16E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.71|P-value:1.42E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:4.17|P-value:2.88E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.03|P-value:5.04E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.49|P-value:7.36E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.79|P-value:1.90E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-2.98|P-value:5.14E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.00|P-value:6.76E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.74|P-value:1.25E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-2.84|P-value:8.88E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.45|P-value:8.80E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.95|P-value:3.46E-8 ID:SGTC_334|Compound:1502-1024|FD-Score:2.96|P-value:6.64E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.64|P-value:3.78E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.02|P-value:5.19E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.52|P-value:9.05E-10 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.53|P-value:5.11E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-2.81|P-value:9.57E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.47|P-value:6.59E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.04|P-value:4.82E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.82|P-value:9.38E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.01|P-value:5.37E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.50|P-value:7.09E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.11|P-value:3.86E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:2.87|P-value:9.10E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.15|P-value:3.16E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.29|P-value:1.44E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.33|P-value:1.24E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:3.75|P-value:2.27E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.11|P-value:3.58E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.98|P-value:7.26E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.81|P-value:9.82E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.99|P-value:5.78E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.85|P-value:9.96E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.67|P-value:3.22E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.84|P-value:8.87E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.05|P-value:4.54E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.20|P-value:2.11E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.06|P-value:5.10E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.80|P-value:8.45E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.15|P-value:3.12E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.00|P-value:5.54E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.41|P-value:8.04E-7 ID:SGTC_2081|Compound:5214970|FD-Score:-3.79|P-value:1.50E-5 ID:SGTC_2139|Compound:5578692|FD-Score:8.64|P-value:2.06E-21 ID:SGTC_2289|Compound:7946404|FD-Score:3.63|P-value:3.92E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.12|P-value:3.62E-6 ID:SGTC_2382|Compound:9035899|FD-Score:3.10|P-value:3.80E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.87|P-value:1.28E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:2.86|P-value:9.62E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.75|P-value:2.23E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.42|P-value:9.98E-5 ID:SGTC_2703|Compound:st077852|FD-Score:-3.29|P-value:1.48E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.04|P-value:4.00E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.88|P-value:1.20E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.58|P-value:3.02E-7 ID:SGTC_17|Compound:0960-0276|FD-Score:3.63|P-value:3.89E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.05|P-value:3.90E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-2.89|P-value:7.16E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.71|P-value:1.42E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:4.17|P-value:2.88E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.03|P-value:5.04E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.49|P-value:7.36E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.79|P-value:1.90E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-2.98|P-value:5.14E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.00|P-value:6.76E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.74|P-value:1.25E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-2.84|P-value:8.88E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.45|P-value:8.80E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.95|P-value:3.46E-8 ID:SGTC_334|Compound:1502-1024|FD-Score:2.96|P-value:6.64E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.64|P-value:3.78E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.02|P-value:5.19E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.52|P-value:9.05E-10 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.53|P-value:5.11E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-2.81|P-value:9.57E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.47|P-value:6.59E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.04|P-value:4.82E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.82|P-value:9.38E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.01|P-value:5.37E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.50|P-value:7.09E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:4.11|P-value:3.86E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:2.87|P-value:9.10E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.15|P-value:3.16E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.29|P-value:1.44E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.33|P-value:1.24E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:3.75|P-value:2.27E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.11|P-value:3.58E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.98|P-value:7.26E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.81|P-value:9.82E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.99|P-value:5.78E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.85|P-value:9.96E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.67|P-value:3.22E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.84|P-value:8.87E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.05|P-value:4.54E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.20|P-value:2.11E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.06|P-value:5.10E-6 ID:SGTC_1742|Compound:st038235|FD-Score:4.80|P-value:8.45E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.15|P-value:3.12E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.00|P-value:5.54E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.41|P-value:8.04E-7 ID:SGTC_2081|Compound:5214970|FD-Score:-3.79|P-value:1.50E-5 ID:SGTC_2139|Compound:5578692|FD-Score:8.64|P-value:2.06E-21 ID:SGTC_2289|Compound:7946404|FD-Score:3.63|P-value:3.92E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.12|P-value:3.62E-6 ID:SGTC_2382|Compound:9035899|FD-Score:3.10|P-value:3.80E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.87|P-value:1.28E-5 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:2.86|P-value:9.62E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.75|P-value:2.23E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.42|P-value:9.98E-5 ID:SGTC_2703|Compound:st077852|FD-Score:-3.29|P-value:1.48E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.04|P-value:4.00E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.88|P-value:1.20E-5

Top fitness defect scores for YKR079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2139 5578692 8.64 56.5 µM 2.06E-21 superoxide 2 2.80E-18 0.12
2 SGTC_565 1418-0001 5.52 44.5 µM 9.05E-10 2 1.71E-8 0.38
3 SGTC_315 k915-0449 4.95 187.0 µM 3.46E-8 5 3.69E-7 0.42
4 SGTC_1742 st038235 4.80 28.9 µM 8.45E-8 mitochondrial stress 5 7.83E-7 0.26
5 SGTC_145 3737-0113 4.74 38.4 µM 1.25E-7 DNA intercalators 33 1.09E-6 0.04
6 SGTC_42 0133-0086 4.71 60.6 µM 1.42E-7 3 1.22E-6 0.10
7 SGTC_9 0092-0002 4.58 10.4 µM 3.02E-7 6 2.30E-6 0.03
8 SGTC_2004 4023728 4.41 41.9 µM 8.04E-7 22 5.25E-6 0.13
9 SGTC_969 1313-0238 4.33 134.0 µM 1.24E-6 mitochondrial processes 19 7.56E-6 0.49
10 SGTC_63 0099-0242 4.17 26.7 µM 2.88E-6 mitochondrial stress 22 1.54E-5 0.33
11 SGTC_2336 9001819 4.12 198.7 µM 3.62E-6 heme biosynthesis & mitochondrial translocase 37 1.88E-5 0.01
12 SGTC_851 0394-0702 4.11 453.0 µM 3.86E-6 mitochondrial processes 20 1.98E-5 0.07
13 SGTC_1740 st038286 4.06 13.2 µM 5.10E-6 7 2.50E-5 0.05
14 SGTC_143 4032-1194 4.00 15.7 µM 6.76E-6 15 3.18E-5 0.11
15 SGTC_1085 doxorubicin 3.98 7.7 µM 7.26E-6 anthracycline transcription coupled DNA repair 7 3.38E-5 0.23
16 SGTC_3327 9140648 3.88 26.9 µM 1.20E-5 14 5.15E-5 0.02
17 SGTC_2384 9036245 3.87 200.0 µM 1.28E-5 3 5.46E-5 0.05
18 SGTC_131 0141-0277 3.79 33.9 µM 1.90E-5 13 7.62E-5 0.05
19 SGTC_2583 asiatic acid 3.75 100.0 µM 2.23E-5 12 8.74E-5 0.12
20 SGTC_994 3910-0338 3.75 138.0 µM 2.27E-5 calcium & mitochondrial duress 16 8.86E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 5.21E-31 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.197 1.02E-30 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.177 7.24E-25 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.173 8.12E-24 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.154 2.61E-19 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.42E-16 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.131 2.99E-14 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.128 8.82E-14 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.128 1.06E-13 YML047W-A_d YML047W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 1.06E-13 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.125 3.54E-13 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.121 2.26E-12 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.121 2.32E-12 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.120 3.22E-12 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 6.77E-12 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching