YKR085C / MRPL20

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR085C / MRPL20

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.01|P-value:1.94E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:3.77|P-value:2.60E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.00|P-value:1.20E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.29|P-value:4.42E-9 ID:SGTC_91|Compound:0417-1751|FD-Score:5.25|P-value:7.59E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.92|P-value:1.25E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:5.78|P-value:5.93E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.23|P-value:5.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.31|P-value:5.50E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:1.00E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:3.18E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.82|P-value:4.87E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.16|P-value:6.52E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.26|P-value:6.59E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-5.40|P-value:6.11E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:5.16|P-value:1.14E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.47|P-value:7.05E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.81|P-value:2.28E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:9.75E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.49|P-value:8.87E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.23|P-value:5.19E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:-4.03|P-value:1.51E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:6.23|P-value:5.86E-9 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.92|P-value:1.59E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.66|P-value:5.24E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.16|P-value:6.70E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.07|P-value:9.14E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.40|P-value:2.67E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.65|P-value:3.89E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.71|P-value:3.23E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.08|P-value:8.96E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.84|P-value:2.09E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.58|P-value:6.81E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.59|P-value:4.71E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.54|P-value:7.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.71|P-value:8.44E-8 ID:SGTC_1780|Compound:st038448|FD-Score:-4.31|P-value:5.42E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.41|P-value:5.65E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.41|P-value:3.87E-9 ID:SGTC_1892|Compound:st058411|FD-Score:-3.68|P-value:4.98E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.60|P-value:4.67E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.67|P-value:3.73E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.61|P-value:4.52E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.47|P-value:2.96E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.50|P-value:8.68E-4 ID:SGTC_2344|Compound:7990960|FD-Score:6.17|P-value:8.02E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.39|P-value:8.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.22|P-value:8.63E-7 ID:SGTC_2813|Compound:7971799|FD-Score:4.34|P-value:3.41E-5 ID:SGTC_2816|Compound:7982706|FD-Score:-4.53|P-value:2.38E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-5.02|P-value:3.26E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-4.54|P-value:2.34E-5 ID:SGTC_2918|Compound:7977171|FD-Score:-4.19|P-value:8.50E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.59|P-value:6.58E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.92|P-value:2.24E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.54|P-value:5.59E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.01|P-value:1.94E-8 ID:SGTC_19|Compound:0279-0214|FD-Score:3.77|P-value:2.60E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.00|P-value:1.20E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.29|P-value:4.42E-9 ID:SGTC_91|Compound:0417-1751|FD-Score:5.25|P-value:7.59E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.92|P-value:1.25E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:5.78|P-value:5.93E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:4.23|P-value:5.20E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.31|P-value:5.50E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:1.00E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:3.18E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.82|P-value:4.87E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:4.16|P-value:6.52E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.26|P-value:6.59E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-5.40|P-value:6.11E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:5.16|P-value:1.14E-6 ID:SGTC_798|Compound:1287-0182|FD-Score:3.47|P-value:7.05E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.81|P-value:2.28E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.05|P-value:9.75E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.49|P-value:8.87E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.23|P-value:5.19E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:-4.03|P-value:1.51E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:6.23|P-value:5.86E-9 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.92|P-value:1.59E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.66|P-value:5.24E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.16|P-value:6.70E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.49|P-value:6.60E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.07|P-value:9.14E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.40|P-value:2.67E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.65|P-value:3.89E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.71|P-value:3.23E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.08|P-value:8.96E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.84|P-value:2.09E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.58|P-value:6.81E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.59|P-value:4.71E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.54|P-value:7.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.71|P-value:8.44E-8 ID:SGTC_1780|Compound:st038448|FD-Score:-4.31|P-value:5.42E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.41|P-value:5.65E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.41|P-value:3.87E-9 ID:SGTC_1892|Compound:st058411|FD-Score:-3.68|P-value:4.98E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.60|P-value:4.67E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.67|P-value:3.73E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.61|P-value:4.52E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.47|P-value:2.96E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.50|P-value:8.68E-4 ID:SGTC_2344|Compound:7990960|FD-Score:6.17|P-value:8.02E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.39|P-value:8.90E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.22|P-value:8.63E-7 ID:SGTC_2813|Compound:7971799|FD-Score:4.34|P-value:3.41E-5 ID:SGTC_2816|Compound:7982706|FD-Score:-4.53|P-value:2.38E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-5.02|P-value:3.26E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-4.54|P-value:2.34E-5 ID:SGTC_2918|Compound:7977171|FD-Score:-4.19|P-value:8.50E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.59|P-value:6.58E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.92|P-value:2.24E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.54|P-value:5.59E-4

Top fitness defect scores for YKR085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 12.40 2.7 µM 1.00E-29 mitochondrial stress 23 2.19E-35
2 SGTC_236 1509-0011 11.30 5.3 µM 3.18E-25 167 5.94E-30
3 SGTC_118 0083-0097 6.92 135.3 µM 1.25E-10 translation 10 2.25E-12
4 SGTC_58 0957-0393 6.29 9.0 µM 4.42E-9 cell wall 196 1.62E-10
5 SGTC_1352 1496-0991 6.23 99.0 µM 5.86E-9 tubulin folding & SWR complex 5 2.27E-10
6 SGTC_2344 7990960 6.17 77.0 µM 8.02E-9 4 3.32E-10
7 SGTC_10 0279-0212 6.01 42.6 µM 1.94E-8 TRP & mitochondrial translation 29 9.53E-10
8 SGTC_119 0121-0043 5.78 24.8 µM 5.93E-8 mitochondrial stress 29 3.64E-9
9 SGTC_1742 st038235 5.71 28.9 µM 8.44E-8 mitochondrial stress 51 5.56E-9
10 SGTC_91 0417-1751 5.25 58.4 µM 7.59E-7 Golgi 19 7.69E-8
11 SGTC_2582 agaric acid 5.22 100.0 µM 8.63E-7 redox potentiating 211 8.96E-8
12 SGTC_673 1082-0474 5.16 110.0 µM 1.14E-6 RSC complex & mRNA processing 33 1.24E-7
13 SGTC_275 trichlorophene 4.82 5.7 µM 4.87E-6 mitochondrial stress 181 7.08E-7
14 SGTC_1480 1070-0044 4.40 41.2 µM 2.67E-5 10 5.39E-6
15 SGTC_2813 7971799 4.34 71.4 µM 3.41E-5 15 7.21E-6
16 SGTC_1136 pergolide 4.23 1.1 µM 5.19E-5 32 1.19E-5
17 SGTC_124 0136-0217 4.23 7.1 µM 5.20E-5 mitochondrial stress 50 1.19E-5
18 SGTC_365 0121-0052 4.16 13.6 µM 6.52E-5 mitochondrial response to ROS 48 1.56E-5
19 SGTC_1362 1611-0397 4.16 101.0 µM 6.70E-5 16 1.61E-5
20 SGTC_1623 st003709 4.08 20.3 µM 8.96E-5 calcium & mitochondrial duress 65 2.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.442 2.17E-160 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.426 9.81E-148 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.424 1.89E-146 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.408 3.07E-134 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.395 1.37E-125 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.394 6.70E-125 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.378 1.84E-114 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.377 8.73E-114 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.374 5.72E-112 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.373 2.15E-111 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.373 5.07E-111 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.367 1.28E-107 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.366 7.36E-107 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.365 3.06E-106 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.365 3.08E-106 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase