YKR087C / OMA1

Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR087C / OMA1

Click on Significant Values for Screen Details ID:SGTC_254|Compound:nsc-64875|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.81|P-value:9.86E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.68|P-value:1.62E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.81|P-value:1.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.11|P-value:3.02E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.49|P-value:3.15E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.89|P-value:1.48E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:8.27E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.38|P-value:9.82E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:3.51|P-value:2.97E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.35|P-value:1.08E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.33|P-value:7.58E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.46|P-value:6.65E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.34|P-value:5.40E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:7.19|P-value:1.37E-12 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:4.24E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.36|P-value:5.03E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:7.60|P-value:7.51E-14 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.30|P-value:6.10E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.22|P-value:8.11E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.89|P-value:7.36E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.11|P-value:3.00E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.96|P-value:6.83E-7 ID:SGTC_1651|Compound:st011928|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.55|P-value:2.54E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.36|P-value:6.83E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.30|P-value:8.31E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.77|P-value:1.13E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.16|P-value:2.48E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.62|P-value:2.82E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.88|P-value:7.61E-5 ID:SGTC_2288|Compound:7946289|FD-Score:-3.47|P-value:4.69E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.20|P-value:8.61E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.83|P-value:9.05E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.33|P-value:5.58E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.84|P-value:8.88E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.41|P-value:8.48E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.93|P-value:6.06E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.32|P-value:5.80E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.67|P-value:2.67E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.29|P-value:6.40E-4 ID:SGTC_2841|Compound:9004761|FD-Score:9.17|P-value:2.76E-19 ID:SGTC_2921|Compound:7974240|FD-Score:5.41|P-value:6.75E-8 ID:SGTC_2977|Compound:9011197|FD-Score:3.92|P-value:6.31E-5 ID:SGTC_2980|Compound:9014342|FD-Score:5.20|P-value:2.00E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.50|P-value:4.27E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.68|P-value:2.28E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.80|P-value:1.42E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.89|P-value:7.35E-5 ID:SGTC_3237|Compound:9133362|FD-Score:5.41|P-value:6.85E-8 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.81|P-value:9.86E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.68|P-value:1.62E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.81|P-value:1.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.11|P-value:3.02E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.49|P-value:3.15E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.89|P-value:1.48E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.21|P-value:8.27E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.21|P-value:8.44E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.38|P-value:9.82E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:3.51|P-value:2.97E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.35|P-value:1.08E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.33|P-value:7.58E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.46|P-value:6.65E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.34|P-value:5.40E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:7.19|P-value:1.37E-12 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:4.24E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.36|P-value:5.03E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:7.60|P-value:7.51E-14 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.30|P-value:6.10E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.22|P-value:8.11E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.89|P-value:7.36E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.11|P-value:3.00E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.96|P-value:6.83E-7 ID:SGTC_1651|Compound:st011928|FD-Score:3.53|P-value:2.81E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.55|P-value:2.54E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-3.36|P-value:6.83E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.30|P-value:8.31E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.77|P-value:1.13E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.16|P-value:2.48E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.62|P-value:2.82E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.88|P-value:7.61E-5 ID:SGTC_2288|Compound:7946289|FD-Score:-3.47|P-value:4.69E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.20|P-value:8.61E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.83|P-value:9.05E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.33|P-value:5.58E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.84|P-value:8.88E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.41|P-value:8.48E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.93|P-value:6.06E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.32|P-value:5.80E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.67|P-value:2.67E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.29|P-value:6.40E-4 ID:SGTC_2841|Compound:9004761|FD-Score:9.17|P-value:2.76E-19 ID:SGTC_2921|Compound:7974240|FD-Score:5.41|P-value:6.75E-8 ID:SGTC_2977|Compound:9011197|FD-Score:3.92|P-value:6.31E-5 ID:SGTC_2980|Compound:9014342|FD-Score:5.20|P-value:2.00E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.50|P-value:4.27E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.61|P-value:2.11E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.68|P-value:2.28E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.80|P-value:1.42E-6 ID:SGTC_3225|Compound:9130819|FD-Score:3.89|P-value:7.35E-5 ID:SGTC_3237|Compound:9133362|FD-Score:5.41|P-value:6.85E-8

Top fitness defect scores for YKR087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2841 9004761 9.17 39.0 µM 2.76E-19 amide catabolism 2 2.30E-20
2 SGTC_1379 2144-0755 7.60 36.5 µM 7.51E-14 2 1.43E-14
3 SGTC_1215 3852-0577 7.19 11.2 µM 1.37E-12 2 3.15E-13
4 SGTC_2921 7974240 5.41 10.7 µM 6.75E-8 20 3.08E-8
5 SGTC_3237 9133362 5.41 49.5 µM 6.85E-8 10 3.13E-8
6 SGTC_2980 9014342 5.20 25.3 µM 2.00E-7 16 9.74E-8
7 SGTC_1589 2',5'-dimethoxyflavone 4.96 47.2 µM 6.83E-7 4 3.59E-7
8 SGTC_3031 9088762 4.80 49.5 µM 1.42E-6 6 7.78E-7
9 SGTC_2781 5567276 4.67 71.4 µM 2.67E-6 27 1.53E-6
10 SGTC_808 0711-0032 4.46 135.0 µM 6.65E-6 7 4.01E-6
11 SGTC_2615 purpurogallin-4-carboxylic acid 4.41 100.0 µM 8.48E-6 redox potentiating 54 5.19E-6
12 SGTC_631 k072-0230 4.38 41.5 µM 9.82E-6 60S ribosome export 10 6.06E-6
13 SGTC_794 k038-0031 4.35 316.0 µM 1.08E-5 ubiquinone biosynthesis & proteasome 95 6.71E-6
14 SGTC_1860 st056228 4.16 74.6 µM 2.48E-5 16 1.62E-5
15 SGTC_1081 sertraline 4.15 6.0 µM 2.54E-5 60S ribosome export 29 1.66E-5
16 SGTC_1586 deoxycorticosterone acetate 4.11 53.7 µM 3.00E-5 6 1.98E-5
17 SGTC_423 5-fluorouracil 4.11 457.0 µM 3.02E-5 exosome 20 1.99E-5
18 SGTC_2759 disulfiram 3.93 3.4 µM 6.06E-5 32 4.16E-5
19 SGTC_2977 9011197 3.92 71.4 µM 6.31E-5 19 4.34E-5
20 SGTC_644 1498-1197 3.89 63.3 µM 7.21E-5 22 5.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.48E-9 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.097 1.86E-8 YLR165C PUS5 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
0.092 9.35E-8 YIR037W HYR1 hom Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
0.089 2.07E-7 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.087 5.18E-7 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
0.085 7.63E-7 YGR218W CRM1 het Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin
0.083 1.29E-6 YOR306C MCH5 hom Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
0.083 1.36E-6 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.081 2.41E-6 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.076 1.01E-5 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.074 1.71E-5 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.073 2.51E-5 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.071 3.51E-5 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.070 5.16E-5 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.069 5.76E-5 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data