YKR088C / TVP38

Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR088C / TVP38

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.35|P-value:4.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.25|P-value:6.37E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.43|P-value:3.32E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.54|P-value:2.23E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.04|P-value:3.08E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:4.86|P-value:7.52E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.80|P-value:8.41E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.40|P-value:3.74E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.55|P-value:2.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.02|P-value:3.47E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.08|P-value:2.62E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.64|P-value:2.11E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.33|P-value:4.89E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.46|P-value:4.87E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.44|P-value:5.37E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.99|P-value:3.88E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.26|P-value:9.58E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.17|P-value:8.26E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.12|P-value:9.80E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.31|P-value:5.50E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.26|P-value:6.66E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.60|P-value:1.48E-8 ID:SGTC_2320|Compound:7373003|FD-Score:3.34|P-value:4.64E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.81|P-value:7.91E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.15|P-value:8.91E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.25|P-value:6.75E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.23|P-value:6.91E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.34|P-value:4.69E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.31|P-value:5.10E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.20|P-value:1.28E-7 ID:SGTC_2870|Compound:9038528|FD-Score:-3.32|P-value:5.30E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.90|P-value:6.06E-7 ID:SGTC_2936|Compound:9038235|FD-Score:5.20|P-value:1.30E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-3.26|P-value:6.54E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.24|P-value:7.07E-4 ID:SGTC_2995|Compound:9067767|FD-Score:5.80|P-value:4.61E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.84|P-value:8.23E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.87|P-value:6.97E-7 ID:SGTC_3298|Compound:9116858|FD-Score:4.45|P-value:5.12E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.35|P-value:4.54E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.74|P-value:1.05E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.25|P-value:6.37E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.43|P-value:3.32E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.54|P-value:2.23E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:4.04|P-value:3.08E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:4.86|P-value:7.52E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:3.80|P-value:8.41E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:3.40|P-value:3.74E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.55|P-value:2.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.02|P-value:3.47E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.08|P-value:2.62E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.43|P-value:3.42E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.64|P-value:2.11E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.34|P-value:4.57E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.33|P-value:4.89E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.46|P-value:4.87E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.44|P-value:5.37E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.99|P-value:3.88E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.26|P-value:9.58E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.17|P-value:8.26E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.12|P-value:9.80E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.31|P-value:5.50E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.26|P-value:6.66E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.60|P-value:1.48E-8 ID:SGTC_2320|Compound:7373003|FD-Score:3.34|P-value:4.64E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.81|P-value:7.91E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.15|P-value:8.91E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.25|P-value:6.75E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.23|P-value:6.91E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.34|P-value:4.69E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.31|P-value:5.10E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_2868|Compound:9035608|FD-Score:5.20|P-value:1.28E-7 ID:SGTC_2870|Compound:9038528|FD-Score:-3.32|P-value:5.30E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.90|P-value:6.06E-7 ID:SGTC_2936|Compound:9038235|FD-Score:5.20|P-value:1.30E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-3.26|P-value:6.54E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.24|P-value:7.07E-4 ID:SGTC_2995|Compound:9067767|FD-Score:5.80|P-value:4.61E-9 ID:SGTC_3004|Compound:9076122|FD-Score:3.49|P-value:2.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.84|P-value:8.23E-7 ID:SGTC_3208|Compound:9114115|FD-Score:4.87|P-value:6.97E-7 ID:SGTC_3298|Compound:9116858|FD-Score:4.45|P-value:5.12E-6

Top fitness defect scores for YKR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2995 9067767 5.80 71.4 µM 4.61E-9 5 3.27E-9
2 SGTC_2191 5911152 5.60 200.0 µM 1.48E-8 3 1.08E-8
3 SGTC_1680 diphenhydramine 5.26 100.0 µM 9.58E-8 NEO1 11 7.26E-8
4 SGTC_2868 9035608 5.20 32.5 µM 1.28E-7 4 9.73E-8
5 SGTC_2936 9038235 5.20 15.6 µM 1.30E-7 5 9.92E-8
6 SGTC_2893 9048488 4.90 26.0 µM 6.06E-7 fatty acid desaturase (OLE1) 10 4.78E-7
7 SGTC_3208 9114115 4.87 49.5 µM 6.97E-7 18 5.51E-7
8 SGTC_712 r015-0009 4.86 80.6 µM 7.52E-7 17 5.95E-7
9 SGTC_3037 9091026 4.84 49.5 µM 8.23E-7 NEO1-PIK1 80 6.52E-7
10 SGTC_1192 1488-0095 4.64 21.4 µM 2.11E-6 8 1.71E-6
11 SGTC_1356 1502-0781 4.46 85.8 µM 4.87E-6 fatty acid desaturase (OLE1) 9 4.01E-6
12 SGTC_3298 9116858 4.45 71.4 µM 5.12E-6 4 4.22E-6
13 SGTC_1460 k062-0059 4.44 9.2 µM 5.37E-6 Golgi 6 4.42E-6
14 SGTC_1123 mangostin 4.08 811.3 nM 2.62E-5 mitochondrial response to ROS 32 2.23E-5
15 SGTC_624 k048-0052 4.04 28.0 µM 3.08E-5 Golgi 11 2.64E-5
16 SGTC_1040 k898-0338 4.02 155.0 µM 3.47E-5 20 2.97E-5
17 SGTC_1583 clindamycin 3.99 39.6 µM 3.88E-5 mitochondrial processes 10 3.33E-5
18 SGTC_2380 9035439 3.81 200.0 µM 7.91E-5 endomembrane recycling 27 6.89E-5
19 SGTC_720 r052-1644 3.80 49.9 µM 8.41E-5 TSC3-RPN4 27 7.33E-5
20 SGTC_294 k038-0071 3.74 157.0 µM 1.05E-4 ubiquinone biosynthesis & proteasome 69 9.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.88E-10 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.106 7.78E-10 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.090 1.86E-7 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.089 2.36E-7 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.088 3.59E-7 YDL063C SYO1 hom Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.088 3.59E-7 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.087 4.38E-7 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.086 5.59E-7 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.081 2.57E-6 YDR141C DOP1 het Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
0.080 3.81E-6 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.080 4.10E-6 YGR157W CHO2 hom Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
0.079 4.36E-6 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.074 1.83E-5 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.074 1.90E-5 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.073 2.30E-5 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele