YKR089C / TGL4

Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR089C / TGL4

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.26|P-value:7.00E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.88|P-value:7.20E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.81|P-value:9.63E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.84|P-value:8.65E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.50|P-value:4.54E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.02|P-value:3.55E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.45|P-value:3.64E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.03|P-value:3.45E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.38|P-value:4.70E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:6.71|P-value:1.89E-11 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.92|P-value:5.42E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.31|P-value:5.34E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.19|P-value:7.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.13|P-value:2.30E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.14|P-value:9.48E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.34|P-value:8.99E-6 ID:SGTC_2160|Compound:5660466|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.77|P-value:9.63E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.38|P-value:4.66E-4 ID:SGTC_2355|Compound:9061122|FD-Score:-4.58|P-value:3.55E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_2382|Compound:9035899|FD-Score:4.58|P-value:3.04E-6 ID:SGTC_2400|Compound:5203494|FD-Score:4.37|P-value:7.95E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.18|P-value:9.29E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.95|P-value:5.19E-7 ID:SGTC_2866|Compound:9034245|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.29|P-value:6.39E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.26|P-value:7.19E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.00|P-value:3.87E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.95|P-value:4.86E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.34|P-value:4.77E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.24|P-value:1.14E-7 ID:SGTC_3346|Compound:9158254|FD-Score:6.52|P-value:6.54E-11 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.26|P-value:7.00E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.88|P-value:7.20E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.81|P-value:9.63E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.84|P-value:8.65E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.50|P-value:4.54E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.28|P-value:5.92E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.02|P-value:3.55E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.45|P-value:3.64E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.03|P-value:3.45E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.38|P-value:4.70E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:6.71|P-value:1.89E-11 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.92|P-value:5.42E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.31|P-value:5.34E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.19|P-value:7.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.13|P-value:2.30E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.14|P-value:9.48E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.34|P-value:8.99E-6 ID:SGTC_2160|Compound:5660466|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.77|P-value:9.63E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-3.38|P-value:4.66E-4 ID:SGTC_2355|Compound:9061122|FD-Score:-4.58|P-value:3.55E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.22|P-value:1.55E-5 ID:SGTC_2382|Compound:9035899|FD-Score:4.58|P-value:3.04E-6 ID:SGTC_2400|Compound:5203494|FD-Score:4.37|P-value:7.95E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.18|P-value:9.29E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.95|P-value:5.19E-7 ID:SGTC_2866|Compound:9034245|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.75|P-value:1.07E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.48|P-value:2.92E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.29|P-value:6.39E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.26|P-value:7.19E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.00|P-value:3.87E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.95|P-value:4.86E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.34|P-value:4.77E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.24|P-value:1.14E-7 ID:SGTC_3346|Compound:9158254|FD-Score:6.52|P-value:6.54E-11

Top fitness defect scores for YKR089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_706 4262-0057 6.71 46.9 µM 1.89E-11 fatty acid desaturase (OLE1) 6 1.00E-11
2 SGTC_3346 9158254 6.52 43.6 µM 6.54E-11 1 3.61E-11
3 SGTC_3300 9124615 5.24 50.5 µM 1.14E-7 3 7.84E-8
4 SGTC_2783 7738165 4.95 71.4 µM 5.19E-7 12 3.74E-7
5 SGTC_2382 9035899 4.58 200.0 µM 3.04E-6 60S ribosome export 9 2.31E-6
6 SGTC_165 k038-0023 4.50 64.4 µM 4.54E-6 ubiquinone biosynthesis & proteasome 59 3.48E-6
7 SGTC_2400 5203494 4.37 178.7 µM 7.95E-6 RSC complex & mRNA processing 19 6.19E-6
8 SGTC_2150 5556613 4.34 200.0 µM 8.99E-6 12 7.03E-6
9 SGTC_2358 9037157 4.22 4.0 µM 1.55E-5 23 1.23E-5
10 SGTC_1687 st020778 4.13 55.4 µM 2.30E-5 167 1.85E-5
11 SGTC_640 3381-0960 4.03 37.1 µM 3.45E-5 8 2.80E-5
12 SGTC_427 1354-0053 4.02 47.3 µM 3.55E-5 19 2.89E-5
13 SGTC_3144 9087057 4.00 49.5 µM 3.87E-5 13 3.15E-5
14 SGTC_3145 9085516 3.95 49.5 µM 4.86E-5 fatty acid desaturase (OLE1) 31 3.98E-5
15 SGTC_1170 0310-0127 3.92 64.8 µM 5.42E-5 30 4.46E-5
16 SGTC_2261 9010538 3.77 184.7 µM 9.63E-5 21 8.05E-5
17 SGTC_2939 9044578 3.75 71.4 µM 1.07E-4 47 8.95E-5
18 SGTC_2866 9034245 3.59 58.4 µM 1.91E-4 12 1.63E-4
19 SGTC_2951 9072950 3.48 58.1 µM 2.92E-4 ERG2 36 2.52E-4
20 SGTC_3249 9135183 3.34 49.5 µM 4.77E-4 60S ribosome export 31 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 5.49E-12 YPL257W_p YPL257W_p hom Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
0.104 1.57E-9 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.085 7.90E-7 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.084 9.99E-7 YBR076W ECM8 hom Non-essential protein of unknown function
0.083 1.43E-6 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.082 1.93E-6 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.081 2.38E-6 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.080 3.15E-6 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.079 4.76E-6 YPR015C_p YPR015C_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.079 4.98E-6 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.077 8.16E-6 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 9.48E-6 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.076 1.14E-5 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.90E-5 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.070 5.24E-5 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex