YKR090W / PXL1

Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR090W / PXL1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.74|P-value:9.48E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.41|P-value:3.12E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.20|P-value:7.12E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.85|P-value:5.55E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:8.04|P-value:4.57E-16 ID:SGTC_982|Compound:1491-0518|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.85|P-value:6.11E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.81|P-value:7.17E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.48|P-value:3.80E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.83|P-value:6.52E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.12|P-value:9.26E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.96|P-value:3.83E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:5.04E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.33|P-value:4.13E-4 ID:SGTC_1678|Compound:st019265|FD-Score:4.90|P-value:4.94E-7 ID:SGTC_1744|Compound:st037937|FD-Score:3.41|P-value:3.37E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.30|P-value:5.98E-8 ID:SGTC_1790|Compound:st045711|FD-Score:-3.91|P-value:4.39E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.12|P-value:9.28E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.26|P-value:5.33E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.52|P-value:2.02E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.27|P-value:5.54E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.27|P-value:9.82E-6 ID:SGTC_2334|Compound:9017922|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.06|P-value:7.09E-10 ID:SGTC_2342|Compound:7990637|FD-Score:3.63|P-value:1.46E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.03|P-value:2.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.18|P-value:3.46E-13 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.19|P-value:7.20E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.27|P-value:5.58E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.41|P-value:5.23E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.84|P-value:6.30E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-4.69|P-value:1.26E-6 ID:SGTC_2823|Compound:7987624|FD-Score:-3.31|P-value:4.49E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.72|P-value:5.38E-9 ID:SGTC_2877|Compound:9040724|FD-Score:-3.46|P-value:2.59E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.29|P-value:5.07E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.01|P-value:3.08E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.68|P-value:1.21E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_3353|Compound:9151644|FD-Score:4.10|P-value:2.15E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:3.74|P-value:9.48E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.41|P-value:3.12E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.20|P-value:7.12E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.16|P-value:1.67E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.85|P-value:5.55E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:8.04|P-value:4.57E-16 ID:SGTC_982|Compound:1491-0518|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.85|P-value:6.11E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.81|P-value:7.17E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.48|P-value:3.80E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.83|P-value:6.52E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.12|P-value:9.26E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.96|P-value:3.83E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.30|P-value:5.04E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.33|P-value:4.13E-4 ID:SGTC_1678|Compound:st019265|FD-Score:4.90|P-value:4.94E-7 ID:SGTC_1744|Compound:st037937|FD-Score:3.41|P-value:3.37E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.30|P-value:5.98E-8 ID:SGTC_1790|Compound:st045711|FD-Score:-3.91|P-value:4.39E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.12|P-value:9.28E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.26|P-value:5.33E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.52|P-value:2.02E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.27|P-value:5.54E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.27|P-value:9.82E-6 ID:SGTC_2334|Compound:9017922|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.06|P-value:7.09E-10 ID:SGTC_2342|Compound:7990637|FD-Score:3.63|P-value:1.46E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.03|P-value:2.81E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.18|P-value:3.46E-13 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.19|P-value:7.20E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.27|P-value:5.58E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.41|P-value:5.23E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.84|P-value:6.30E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-4.69|P-value:1.26E-6 ID:SGTC_2823|Compound:7987624|FD-Score:-3.31|P-value:4.49E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.72|P-value:5.38E-9 ID:SGTC_2877|Compound:9040724|FD-Score:-3.46|P-value:2.59E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.29|P-value:5.07E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.01|P-value:3.08E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.68|P-value:1.21E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.51|P-value:2.26E-4 ID:SGTC_3353|Compound:9151644|FD-Score:4.10|P-value:2.15E-5

Top fitness defect scores for YKR090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_977 1348-1378 8.04 135.0 µM 4.57E-16 1 4.51E-16
2 SGTC_2350 9023895 7.18 38.9 µM 3.46E-13 ergosterol biosynthesis 6 3.40E-13
3 SGTC_2337 9009472 6.06 200.0 µM 7.09E-10 6 6.92E-10
4 SGTC_2862 9027634 5.72 71.4 µM 5.38E-9 ERG2 13 5.25E-9
5 SGTC_1775 st081588 5.30 35.2 µM 5.98E-8 60S ribosome export 9 5.83E-8
6 SGTC_1678 st019265 4.90 80.2 µM 4.94E-7 60S ribosome export 8 4.81E-7
7 SGTC_1108 betulinic acid 4.48 729.1 nM 3.80E-6 7 3.70E-6
8 SGTC_2767 sibutramine 4.41 71.5 µM 5.23E-6 12 5.10E-6
9 SGTC_2267 7931562 4.27 200.0 µM 9.82E-6 13 9.57E-6
10 SGTC_891 0929-0073 4.16 133.0 µM 1.67E-5 19 1.62E-5
11 SGTC_707 0865-0008 4.12 204.0 µM 1.95E-5 DNA damage response 3 1.91E-5
12 SGTC_3353 9151644 4.10 39.3 µM 2.15E-5 10 2.10E-5
13 SGTC_2349 9023730 4.03 187.1 µM 2.81E-5 21 2.74E-5
14 SGTC_2977 9011197 4.01 71.4 µM 3.08E-5 17 3.01E-5
15 SGTC_1324 1418-0026 3.96 34.4 µM 3.83E-5 11 3.74E-5
16 SGTC_1015 4130-4525 3.85 82.0 µM 6.11E-5 60S ribosome export 25 5.96E-5
17 SGTC_2789 5281112 3.84 71.4 µM 6.30E-5 42 6.14E-5
18 SGTC_1199 1638-0010 3.83 4.5 µM 6.52E-5 endomembrane recycling 30 6.36E-5
19 SGTC_997 3996-0078 3.81 137.0 µM 7.05E-5 27 6.87E-5
20 SGTC_1073 triclabendazole 3.81 3.1 µM 7.17E-5 30 6.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.00E-18 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.101 5.33E-9 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.100 6.92E-9 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.095 3.17E-8 YOR013W_d IRC11_d hom Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
0.093 7.33E-8 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.091 1.29E-7 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.66E-6 YLL002W RTT109 hom Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
0.082 2.02E-6 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.075 1.33E-5 YPR172W_p YPR172W_p hom Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication
0.075 1.37E-5 YIL066C RNR3 hom Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
0.075 1.53E-5 YER096W SHC1 hom Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
0.073 2.49E-5 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.070 4.73E-5 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.070 4.78E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.068 8.44E-5 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control