YKR091W / SRL3

Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR091W / SRL3

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.25|P-value:6.17E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:5.89|P-value:2.15E-9 ID:SGTC_94|Compound:0334-0113|FD-Score:6.65|P-value:1.66E-11 ID:SGTC_136|Compound:0097-0015|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.61|P-value:1.43E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.05|P-value:2.82E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.17|P-value:7.30E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.23|P-value:6.62E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.51|P-value:2.97E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.53|P-value:1.92E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.41|P-value:3.07E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.77|P-value:8.77E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.47|P-value:3.64E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.97|P-value:3.87E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.21|P-value:6.25E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.80|P-value:7.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.18|P-value:7.78E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.18|P-value:7.81E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.15|P-value:8.76E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.30|P-value:9.36E-6 ID:SGTC_1896|Compound:st058441|FD-Score:7.38|P-value:9.60E-14 ID:SGTC_1987|Compound:st072290|FD-Score:3.87|P-value:5.99E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.17|P-value:8.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.68|P-value:1.60E-6 ID:SGTC_2187|Compound:6125751|FD-Score:3.32|P-value:4.87E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.87|P-value:5.83E-5 ID:SGTC_2231|Compound:micatex|FD-Score:-3.28|P-value:4.97E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.68|P-value:1.62E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.89|P-value:5.35E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.01|P-value:3.35E-5 ID:SGTC_2345|Compound:9052315|FD-Score:4.58|P-value:2.59E-6 ID:SGTC_2352|Compound:9027995|FD-Score:3.39|P-value:3.82E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-6.74|P-value:7.10E-12 ID:SGTC_2427|Compound:5545055|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.28|P-value:4.97E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.92|P-value:4.82E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.84|P-value:6.67E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-3.99|P-value:3.05E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.24|P-value:9.22E-8 ID:SGTC_2999|Compound:9069765|FD-Score:3.75|P-value:9.60E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.38|P-value:3.94E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.43|P-value:3.31E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.14|P-value:8.04E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.25|P-value:6.17E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:5.89|P-value:2.15E-9 ID:SGTC_94|Compound:0334-0113|FD-Score:6.65|P-value:1.66E-11 ID:SGTC_136|Compound:0097-0015|FD-Score:3.25|P-value:6.12E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.61|P-value:1.43E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.05|P-value:2.82E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.17|P-value:7.30E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.23|P-value:6.62E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.51|P-value:2.97E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.53|P-value:1.92E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.41|P-value:3.07E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.77|P-value:8.77E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-4.47|P-value:3.64E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.97|P-value:3.87E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.21|P-value:6.25E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.80|P-value:7.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.18|P-value:7.78E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.18|P-value:7.81E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.15|P-value:8.76E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.30|P-value:9.36E-6 ID:SGTC_1896|Compound:st058441|FD-Score:7.38|P-value:9.60E-14 ID:SGTC_1987|Compound:st072290|FD-Score:3.87|P-value:5.99E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.17|P-value:8.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.68|P-value:1.60E-6 ID:SGTC_2187|Compound:6125751|FD-Score:3.32|P-value:4.87E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.87|P-value:5.83E-5 ID:SGTC_2231|Compound:micatex|FD-Score:-3.28|P-value:4.97E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.68|P-value:1.62E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.89|P-value:5.35E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.01|P-value:3.35E-5 ID:SGTC_2345|Compound:9052315|FD-Score:4.58|P-value:2.59E-6 ID:SGTC_2352|Compound:9027995|FD-Score:3.39|P-value:3.82E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-6.74|P-value:7.10E-12 ID:SGTC_2427|Compound:5545055|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.28|P-value:4.97E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.92|P-value:4.82E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.84|P-value:6.67E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-3.99|P-value:3.05E-5 ID:SGTC_2972|Compound:9093619|FD-Score:5.24|P-value:9.22E-8 ID:SGTC_2999|Compound:9069765|FD-Score:3.75|P-value:9.60E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.38|P-value:3.94E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.43|P-value:3.31E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.14|P-value:8.04E-4

Top fitness defect scores for YKR091W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1896 st058441 7.38 89.0 µM 9.60E-14 1 8.13E-14
2 SGTC_94 0334-0113 6.65 514.8 µM 1.66E-11 2 1.43E-11
3 SGTC_93 0109-0045 5.89 59.2 µM 2.15E-9 DNA damage response 12 1.89E-9
4 SGTC_2972 9093619 5.24 59.9 µM 9.22E-8 4 8.23E-8
5 SGTC_2099 5377090 4.68 177.4 µM 1.60E-6 9 1.44E-6
6 SGTC_2296 7971656 4.68 126.5 µM 1.62E-6 26 1.47E-6
7 SGTC_2345 9052315 4.58 157.4 µM 2.59E-6 11 2.35E-6
8 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.30 14.9 µM 9.36E-6 6 8.53E-6
9 SGTC_343 4130-2827 4.05 29.8 µM 2.82E-5 28 2.59E-5
10 SGTC_2332 7982454 4.01 138.9 µM 3.35E-5 46 3.07E-5
11 SGTC_861 0443-0273 3.97 110.0 µM 3.87E-5 10 3.55E-5
12 SGTC_2744 captopril 3.92 92.0 µM 4.82E-5 60S ribosome export 10 4.43E-5
13 SGTC_2321 7390090 3.89 138.8 µM 5.35E-5 29 4.92E-5
14 SGTC_2188 6126565 3.87 140.7 µM 5.83E-5 mitochondrial processes 15 5.36E-5
15 SGTC_1987 st072290 3.87 61.9 µM 5.99E-5 16 5.51E-5
16 SGTC_2802 7925815 3.84 54.5 µM 6.67E-5 48 6.14E-5
17 SGTC_1461 k072-0203 3.80 53.8 µM 7.98E-5 15 7.35E-5
18 SGTC_578 3460-0051 3.77 92.0 µM 8.77E-5 13 8.09E-5
19 SGTC_2999 9069765 3.75 71.4 µM 9.60E-5 amide catabolism 35 8.86E-5
20 SGTC_2647 atorvastatin 3.71 60.2 µM 1.13E-4 azole & statin 21 1.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.37E-9 YNL202W SPS19 hom Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
0.085 8.00E-7 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.084 1.16E-6 YJL123C MTC1 hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
0.084 1.26E-6 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.081 2.77E-6 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.077 8.36E-6 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.070 4.45E-5 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.067 9.86E-5 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.066 1.33E-4 YDR433W_d YDR433W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.39E-4 YOL118C_d YOL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.065 1.62E-4 YNR065C_p YNR065C_p hom Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene
0.065 1.78E-4 YHR048W_p YHK8_p hom Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
0.064 2.31E-4 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
0.060 5.35E-4 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.060 5.44E-4 YDL088C ASM4 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication