YKR092C / SRP40

Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR092C / SRP40

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:-4.60|P-value:7.78E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:7.85|P-value:1.72E-16 ID:SGTC_123|Compound:0083-0120|FD-Score:4.64|P-value:7.39E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.26|P-value:2.37E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.15|P-value:4.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.37|P-value:2.49E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:4.09|P-value:1.09E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.36|P-value:2.26E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.41|P-value:1.79E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.00|P-value:9.43E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.82|P-value:3.32E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.87|P-value:2.10E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.18|P-value:4.86E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:5.99E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.90|P-value:1.87E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:2.63E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.06|P-value:6.91E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.46|P-value:1.68E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.37|P-value:2.85E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.93|P-value:2.33E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.16|P-value:8.11E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.01|P-value:9.15E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-4.35|P-value:2.80E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.87|P-value:2.65E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.06|P-value:1.11E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.26|P-value:4.41E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.60|P-value:8.95E-7 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.57|P-value:1.07E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.06|P-value:7.62E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.25|P-value:3.76E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.06|P-value:6.75E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.19|P-value:6.78E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.82|P-value:3.74E-5 ID:SGTC_1932|Compound:st074806|FD-Score:4.77|P-value:3.80E-7 ID:SGTC_1934|Compound:st074720|FD-Score:-3.51|P-value:1.23E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.19|P-value:4.72E-4 ID:SGTC_2012|Compound:4023501|FD-Score:5.37|P-value:1.22E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:8.78E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.66|P-value:6.58E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.89|P-value:4.85E-10 ID:SGTC_2362|Compound:9071156|FD-Score:-3.06|P-value:6.95E-4 ID:SGTC_2397|Compound:5161689|FD-Score:6.00|P-value:2.38E-10 ID:SGTC_2400|Compound:5203494|FD-Score:6.41|P-value:1.37E-11 ID:SGTC_2456|Compound:5770359|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.54|P-value:1.22E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.18|P-value:6.26E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.22|P-value:5.97E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.60|P-value:9.46E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.73|P-value:1.31E-9 ID:SGTC_2930|Compound:9013230|FD-Score:-2.96|P-value:9.93E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.38|P-value:2.80E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.20|P-value:4.50E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.62|P-value:8.75E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.27|P-value:3.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.07|P-value:1.21E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.60|P-value:7.78E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:7.85|P-value:1.72E-16 ID:SGTC_123|Compound:0083-0120|FD-Score:4.64|P-value:7.39E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.26|P-value:2.37E-8 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.53|P-value:1.27E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.15|P-value:4.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.37|P-value:2.49E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:4.09|P-value:1.09E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.36|P-value:2.26E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.41|P-value:1.79E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.00|P-value:9.43E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.82|P-value:3.32E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.87|P-value:2.10E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:3.18|P-value:4.86E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:5.99E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:4.90|P-value:1.87E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.35|P-value:2.63E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.06|P-value:6.91E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.44|P-value:1.78E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.46|P-value:1.68E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.37|P-value:2.85E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.93|P-value:2.33E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.16|P-value:8.11E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.01|P-value:9.15E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-4.35|P-value:2.80E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.87|P-value:2.65E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:-4.06|P-value:1.11E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.26|P-value:4.41E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.60|P-value:8.95E-7 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.57|P-value:1.07E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.05|P-value:7.87E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.06|P-value:7.62E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.25|P-value:3.76E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.06|P-value:6.75E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.19|P-value:6.78E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.82|P-value:3.74E-5 ID:SGTC_1932|Compound:st074806|FD-Score:4.77|P-value:3.80E-7 ID:SGTC_1934|Compound:st074720|FD-Score:-3.51|P-value:1.23E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.19|P-value:4.72E-4 ID:SGTC_2012|Compound:4023501|FD-Score:5.37|P-value:1.22E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:8.78E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.66|P-value:6.58E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_2302|Compound:7771753|FD-Score:5.89|P-value:4.85E-10 ID:SGTC_2362|Compound:9071156|FD-Score:-3.06|P-value:6.95E-4 ID:SGTC_2397|Compound:5161689|FD-Score:6.00|P-value:2.38E-10 ID:SGTC_2400|Compound:5203494|FD-Score:6.41|P-value:1.37E-11 ID:SGTC_2456|Compound:5770359|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.54|P-value:1.22E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.26|P-value:3.62E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.18|P-value:6.26E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.22|P-value:5.97E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.60|P-value:9.46E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.73|P-value:1.31E-9 ID:SGTC_2930|Compound:9013230|FD-Score:-2.96|P-value:9.93E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.38|P-value:2.80E-6 ID:SGTC_2958|Compound:9077254|FD-Score:3.25|P-value:3.84E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.80|P-value:4.03E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.20|P-value:4.50E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.62|P-value:8.75E-5 ID:SGTC_3179|Compound:9107801|FD-Score:3.27|P-value:3.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.07|P-value:1.21E-5

Top fitness defect scores for YKR092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_118 0083-0097 7.85 135.3 µM 1.72E-16 translation 5 2.07E-15
2 SGTC_2400 5203494 6.41 178.7 µM 1.37E-11 RSC complex & mRNA processing 4 7.17E-11
3 SGTC_2397 5161689 6.00 200.0 µM 2.38E-10 5 1.01E-9
4 SGTC_2302 7771753 5.89 200.0 µM 4.85E-10 14 1.95E-9
5 SGTC_2697 mebhydrolin 5.73 72.4 µM 1.31E-9 NEO1 34 4.91E-9
6 SGTC_2012 4023501 5.37 200.0 µM 1.22E-8 8 3.89E-8
7 SGTC_241 5hr heat shock (37°C) + cantharidin 5.26 155.4 µM 2.37E-8 cell wall signaling 41 7.19E-8
8 SGTC_694 1315-0438 4.90 43.2 µM 1.87E-7 3 4.87E-7
9 SGTC_549 1661-1316 4.87 519.0 µM 2.10E-7 5 5.44E-7
10 SGTC_1932 st074806 4.77 40.9 µM 3.80E-7 7 9.42E-7
11 SGTC_123 0083-0120 4.64 66.7 µM 7.39E-7 30 1.75E-6
12 SGTC_1381 2324-0066 4.60 62.1 µM 8.95E-7 19 2.09E-6
13 SGTC_2938 9059746 4.38 27.3 µM 2.80E-6 fatty acid desaturase (OLE1) 32 6.02E-6
14 SGTC_1069 diphenylcyclopropenone 4.37 8.5 µM 2.85E-6 28 6.12E-6
15 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.22 100.0 µM 5.97E-6 17 1.22E-5
16 SGTC_1921 5740136 4.19 50.0 µM 6.78E-6 TRP & mitochondrial translation 47 1.37E-5
17 SGTC_1132 3456-3614 4.16 2.5 µM 8.11E-6 tubulin folding & SWR complex 35 1.62E-5
18 SGTC_1868 st057644 4.11 42.7 µM 1.03E-5 29 2.01E-5
19 SGTC_364 0083-0097 4.09 67.7 µM 1.09E-5 21 2.13E-5
20 SGTC_3216 9129716 4.07 49.5 µM 1.21E-5 RPP1 & pyrimidine depletion 22 2.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.94E-14 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.124 6.88E-13 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.123 9.03E-13 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.123 9.54E-13 YBR017C KAP104 hom Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
0.112 9.48E-11 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.111 1.01E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.108 3.30E-10 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.107 5.38E-10 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.104 1.76E-9 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.102 2.95E-9 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.102 3.62E-9 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.099 8.29E-9 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.097 1.78E-8 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.096 2.21E-8 YDL075W RPL31A hom Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
0.093 5.94E-8 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)