YKR093W / PTR2

Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR093W / PTR2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.09|P-value:1.81E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.41|P-value:1.24E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.60|P-value:8.61E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.33|P-value:1.74E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:3.94|P-value:2.99E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.86|P-value:3.90E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.03|P-value:2.24E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.96|P-value:2.83E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.41|P-value:1.19E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.30|P-value:3.73E-27 ID:SGTC_295|Compound:k015-0027|FD-Score:3.76|P-value:5.28E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.72|P-value:1.93E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.84|P-value:4.16E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.96|P-value:2.77E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:10.20|P-value:2.36E-19 ID:SGTC_527|Compound:4476-4215|FD-Score:4.46|P-value:5.13E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.49|P-value:6.98E-14 ID:SGTC_548|Compound:1436-0017|FD-Score:5.79|P-value:2.27E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:5.75|P-value:2.72E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:7.62|P-value:1.54E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:4.69|P-value:2.17E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:3.67|P-value:6.85E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.69|P-value:6.51E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.31|P-value:1.84E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:6.34|P-value:1.64E-8 ID:SGTC_884|Compound:0851-0618|FD-Score:4.91|P-value:9.42E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:6.24|P-value:2.76E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:7.09|P-value:3.31E-10 ID:SGTC_975|Compound:1335-0046|FD-Score:4.35|P-value:7.60E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:4.38|P-value:6.85E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.65|P-value:7.33E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.38|P-value:6.86E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.36|P-value:7.22E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.32|P-value:8.28E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.65|P-value:3.35E-9 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.07|P-value:1.96E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.81|P-value:2.05E-7 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.94|P-value:2.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.86|P-value:3.80E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.13|P-value:1.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.90|P-value:7.32E-22 ID:SGTC_1606|Compound:st000094|FD-Score:4.49|P-value:4.50E-5 ID:SGTC_1687|Compound:st020778|FD-Score:10.20|P-value:3.74E-19 ID:SGTC_1694|Compound:st024011|FD-Score:4.37|P-value:7.01E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.67|P-value:2.35E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.15|P-value:1.47E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-4.18|P-value:1.33E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.85|P-value:4.00E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.61|P-value:2.92E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.85|P-value:1.20E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.69|P-value:3.58E-7 ID:SGTC_1886|Compound:st057356|FD-Score:4.30|P-value:9.07E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.12|P-value:1.63E-4 ID:SGTC_1941|Compound:st076221|FD-Score:9.23|P-value:4.30E-16 ID:SGTC_1974|Compound:st069448|FD-Score:4.78|P-value:1.56E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.94|P-value:8.34E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.56|P-value:9.71E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.20|P-value:2.90E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:13.20|P-value:6.00E-31 ID:SGTC_2135|Compound:5326629|FD-Score:4.48|P-value:4.68E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.71|P-value:6.14E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.75|P-value:1.75E-5 ID:SGTC_2301|Compound:7769476|FD-Score:4.43|P-value:5.66E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.08|P-value:4.81E-6 ID:SGTC_2404|Compound:5161160|FD-Score:4.23|P-value:1.15E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.62|P-value:2.84E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-4.40|P-value:6.16E-5 ID:SGTC_2457|Compound:5731572|FD-Score:-5.90|P-value:1.36E-7 ID:SGTC_2458|Compound:5808907|FD-Score:-4.31|P-value:8.62E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-4.29|P-value:9.06E-5 ID:SGTC_2475|Compound:5812728|FD-Score:7.86|P-value:3.72E-12 ID:SGTC_2482|Compound:5981709|FD-Score:5.97|P-value:9.76E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-4.57|P-value:3.34E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.98|P-value:2.64E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:6.93E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.43|P-value:5.78E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.79|P-value:1.50E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:6.97|P-value:6.26E-10 ID:SGTC_2676|Compound:harmalol|FD-Score:4.10|P-value:1.76E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.85|P-value:4.05E-12 ID:SGTC_2816|Compound:7982706|FD-Score:9.79|P-value:6.99E-18 ID:SGTC_2820|Compound:7989630|FD-Score:5.09|P-value:4.66E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.92|P-value:3.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.27|P-value:9.80E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.90|P-value:9.89E-6 ID:SGTC_3025|Compound:9087895|FD-Score:4.23|P-value:1.13E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.33|P-value:7.96E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.48|P-value:8.82E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.57|P-value:3.46E-5 ID:SGTC_3120|Compound:9124077|FD-Score:4.04|P-value:2.14E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.63|P-value:7.76E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.78|P-value:4.93E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.05|P-value:2.08E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.23|P-value:2.80E-8 ID:SGTC_3209|Compound:9113616|FD-Score:5.15|P-value:3.65E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-4.91|P-value:9.25E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.66|P-value:7.06E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.76|P-value:2.59E-7 ID:SGTC_3350|Compound:9150499|FD-Score:4.72|P-value:1.99E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.89|P-value:3.52E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.09|P-value:1.81E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.41|P-value:1.24E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.60|P-value:8.61E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:6.33|P-value:1.74E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:3.94|P-value:2.99E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.86|P-value:3.90E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.03|P-value:2.24E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.96|P-value:2.83E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.41|P-value:1.19E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.30|P-value:3.73E-27 ID:SGTC_295|Compound:k015-0027|FD-Score:3.76|P-value:5.28E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.72|P-value:1.93E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.84|P-value:4.16E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.96|P-value:2.77E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:10.20|P-value:2.36E-19 ID:SGTC_527|Compound:4476-4215|FD-Score:4.46|P-value:5.13E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:8.49|P-value:6.98E-14 ID:SGTC_548|Compound:1436-0017|FD-Score:5.79|P-value:2.27E-7 ID:SGTC_598|Compound:3937-0236|FD-Score:5.75|P-value:2.72E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:7.62|P-value:1.54E-11 ID:SGTC_683|Compound:panaxydol|FD-Score:4.69|P-value:2.17E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:3.67|P-value:6.85E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.69|P-value:6.51E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.31|P-value:1.84E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:6.34|P-value:1.64E-8 ID:SGTC_884|Compound:0851-0618|FD-Score:4.91|P-value:9.42E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:6.24|P-value:2.76E-8 ID:SGTC_955|Compound:1216-0110|FD-Score:7.09|P-value:3.31E-10 ID:SGTC_975|Compound:1335-0046|FD-Score:4.35|P-value:7.60E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:4.38|P-value:6.85E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.65|P-value:7.33E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.38|P-value:6.86E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.36|P-value:7.22E-5 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.32|P-value:8.28E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.65|P-value:3.35E-9 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.07|P-value:1.96E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.81|P-value:2.05E-7 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.94|P-value:2.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.86|P-value:3.80E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.13|P-value:1.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.90|P-value:7.32E-22 ID:SGTC_1606|Compound:st000094|FD-Score:4.49|P-value:4.50E-5 ID:SGTC_1687|Compound:st020778|FD-Score:10.20|P-value:3.74E-19 ID:SGTC_1694|Compound:st024011|FD-Score:4.37|P-value:7.01E-5 ID:SGTC_1700|Compound:st030840|FD-Score:4.67|P-value:2.35E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.15|P-value:1.47E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-4.18|P-value:1.33E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.85|P-value:4.00E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.61|P-value:2.92E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.85|P-value:1.20E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.69|P-value:3.58E-7 ID:SGTC_1886|Compound:st057356|FD-Score:4.30|P-value:9.07E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.12|P-value:1.63E-4 ID:SGTC_1941|Compound:st076221|FD-Score:9.23|P-value:4.30E-16 ID:SGTC_1974|Compound:st069448|FD-Score:4.78|P-value:1.56E-5 ID:SGTC_2008|Compound:4012253|FD-Score:4.94|P-value:8.34E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.56|P-value:9.71E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.20|P-value:2.90E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:13.20|P-value:6.00E-31 ID:SGTC_2135|Compound:5326629|FD-Score:4.48|P-value:4.68E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.71|P-value:6.14E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.75|P-value:1.75E-5 ID:SGTC_2301|Compound:7769476|FD-Score:4.43|P-value:5.66E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.08|P-value:4.81E-6 ID:SGTC_2404|Compound:5161160|FD-Score:4.23|P-value:1.15E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.62|P-value:2.84E-5 ID:SGTC_2455|Compound:5377712|FD-Score:-4.40|P-value:6.16E-5 ID:SGTC_2457|Compound:5731572|FD-Score:-5.90|P-value:1.36E-7 ID:SGTC_2458|Compound:5808907|FD-Score:-4.31|P-value:8.62E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-4.29|P-value:9.06E-5 ID:SGTC_2475|Compound:5812728|FD-Score:7.86|P-value:3.72E-12 ID:SGTC_2482|Compound:5981709|FD-Score:5.97|P-value:9.76E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-4.57|P-value:3.34E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.98|P-value:2.64E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:6.93E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.43|P-value:5.78E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.79|P-value:1.50E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:6.97|P-value:6.26E-10 ID:SGTC_2676|Compound:harmalol|FD-Score:4.10|P-value:1.76E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.85|P-value:4.05E-12 ID:SGTC_2816|Compound:7982706|FD-Score:9.79|P-value:6.99E-18 ID:SGTC_2820|Compound:7989630|FD-Score:5.09|P-value:4.66E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.92|P-value:3.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.27|P-value:9.80E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.90|P-value:9.89E-6 ID:SGTC_3025|Compound:9087895|FD-Score:4.23|P-value:1.13E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.33|P-value:7.96E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.48|P-value:8.82E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.57|P-value:3.46E-5 ID:SGTC_3120|Compound:9124077|FD-Score:4.04|P-value:2.14E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.63|P-value:7.76E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.78|P-value:4.93E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.05|P-value:2.08E-4 ID:SGTC_3207|Compound:9114163|FD-Score:6.23|P-value:2.80E-8 ID:SGTC_3209|Compound:9113616|FD-Score:5.15|P-value:3.65E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-4.91|P-value:9.25E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.66|P-value:7.06E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.76|P-value:2.59E-7 ID:SGTC_3350|Compound:9150499|FD-Score:4.72|P-value:1.99E-5 ID:SGTC_3355|Compound:9151058|FD-Score:3.89|P-value:3.52E-4

Top fitness defect scores for YKR093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2130 NSC 7 13.20 2.5 µM 6.00E-31 copper-dependent oxidative stress 1 4.06E-40
2 SGTC_275 trichlorophene 12.30 5.7 µM 3.73E-27 mitochondrial stress 19 3.92E-35
3 SGTC_1495 4469-0029 10.90 237.0 µM 7.32E-22 11 3.52E-28
4 SGTC_505 gw-5074 10.20 63.9 µM 2.36E-19 12 6.94E-25
5 SGTC_1687 st020778 10.20 55.4 µM 3.74E-19 46 1.27E-24
6 SGTC_2816 7982706 9.79 58.4 µM 6.99E-18 azole & statin 6 5.93E-23
7 SGTC_1941 st076221 9.23 61.8 µM 4.30E-16 sphingolipid biosynthesis & PDR1 16 1.32E-20
8 SGTC_528 3492-0019 8.49 172.0 µM 6.98E-14 calcium & mitochondrial duress 62 1.05E-17
9 SGTC_2475 5812728 7.86 15.0 µM 3.72E-12 mitochondrial processes 1 1.92E-15
10 SGTC_2752 diclazuril 7.85 33.1 µM 4.05E-12 39 2.15E-15
11 SGTC_664 1222-0054 7.62 14.9 µM 1.54E-11 sphingolipid biosynthesis & PDR1 10 1.24E-14
12 SGTC_955 1216-0110 7.09 33.0 µM 3.31E-10 sphingolipid biosynthesis & PDR1 25 6.87E-13
13 SGTC_2665 lovastatin 6.97 100.0 µM 6.26E-10 1 1.58E-12
14 SGTC_1287 0971-0001 6.65 34.6 µM 3.35E-9 sphingolipid biosynthesis & PDR1 18 1.42E-11
15 SGTC_841 0251-0215 6.34 91.2 µM 1.64E-8 34 1.14E-10
16 SGTC_156 3474-0145 6.33 5.6 µM 1.74E-8 endomembrane recycling 16 1.23E-10
17 SGTC_908 3448-7491 6.24 47.7 µM 2.76E-8 mitochondrial stress 41 2.24E-10
18 SGTC_3207 9114163 6.23 49.5 µM 2.80E-8 3 2.29E-10
19 SGTC_2482 5981709 5.97 142.7 µM 9.76E-8 PDR1 10 1.17E-9
20 SGTC_1307 1187-1599 5.81 12.2 µM 2.05E-7 PDR1 3 3.09E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.443 2.39E-161 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.360 2.23E-103 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.318 7.49E-80 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.289 1.44E-65 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.267 8.07E-56 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.257 1.02E-51 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.257 1.24E-51 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.256 2.31E-51 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.253 4.89E-50 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.240 3.48E-45 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.217 3.14E-37 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.208 2.85E-34 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.206 1.68E-33 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.203 1.53E-32 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.197 8.07E-31 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies