YKR094C / RPL40B

Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR094C / RPL40B

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.66|P-value:1.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.21|P-value:8.32E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.12|P-value:1.70E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:4.61E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.14|P-value:8.50E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.42|P-value:3.99E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.64|P-value:1.83E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.19|P-value:1.46E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.11|P-value:2.53E-7 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.32|P-value:5.67E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.95|P-value:4.16E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.86|P-value:5.83E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.39|P-value:5.72E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.46|P-value:5.83E-6 ID:SGTC_1632|Compound:st005650|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.07|P-value:2.48E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:8.71|P-value:2.46E-18 ID:SGTC_1712|Compound:st032288|FD-Score:-3.16|P-value:9.77E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.23|P-value:1.67E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.11|P-value:2.04E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.68|P-value:1.52E-4 ID:SGTC_2023|Compound:5144124|FD-Score:5.56|P-value:1.55E-8 ID:SGTC_2602|Compound:kawain|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.77|P-value:1.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.18|P-value:9.15E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.13|P-value:8.69E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:3.72E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.38|P-value:4.60E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.66|P-value:1.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.21|P-value:8.32E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.12|P-value:1.70E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:4.61E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.14|P-value:8.50E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.42|P-value:3.99E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.64|P-value:1.83E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.52|P-value:2.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.19|P-value:1.46E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:-5.11|P-value:2.53E-7 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.32|P-value:5.67E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.95|P-value:4.16E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.86|P-value:5.83E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.39|P-value:5.72E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.46|P-value:5.83E-6 ID:SGTC_1632|Compound:st005650|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.07|P-value:2.48E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:8.71|P-value:2.46E-18 ID:SGTC_1712|Compound:st032288|FD-Score:-3.16|P-value:9.77E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.23|P-value:1.67E-5 ID:SGTC_1761|Compound:st044296|FD-Score:4.11|P-value:2.04E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.68|P-value:1.52E-4 ID:SGTC_2023|Compound:5144124|FD-Score:5.56|P-value:1.55E-8 ID:SGTC_2602|Compound:kawain|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_2692|Compound:st077426|FD-Score:-3.77|P-value:1.10E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.54|P-value:2.06E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.18|P-value:9.15E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.13|P-value:8.69E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:3.72E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.38|P-value:4.60E-4

Top fitness defect scores for YKR094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1680 diphenhydramine 8.71 100.0 µM 2.46E-18 NEO1 2 1.46E-18
2 SGTC_2023 5144124 5.56 124.0 µM 1.55E-8 2 1.34E-8
3 SGTC_454 lyso-paf C-16 5.12 6.7 µM 1.70E-7 4 1.52E-7
4 SGTC_1365 1672-3266 4.95 55.4 µM 4.16E-7 3 3.77E-7
5 SGTC_1204 4049-0315 4.19 18.3 µM 1.46E-5 21 1.39E-5
6 SGTC_1761 st044296 4.11 37.0 µM 2.04E-5 12 1.95E-5
7 SGTC_1676 st018489 4.07 23.4 µM 2.48E-5 60S ribosome export 31 2.38E-5
8 SGTC_1378 2093-0007 3.86 380.0 nM 5.83E-5 24 5.65E-5
9 SGTC_1374 2889-5571 3.72 141.0 µM 1.02E-4 RSC complex & mRNA processing 46 9.92E-5
10 SGTC_140 0062-0056 3.66 502.5 µM 1.28E-4 30 1.25E-4
11 SGTC_2691 st077356 3.60 60.2 µM 1.64E-4 46 1.60E-4
12 SGTC_2765 myclobutanil 3.54 7.7 µM 2.06E-4 azole & statin 68 2.02E-4
13 SGTC_808 0711-0032 3.52 135.0 µM 2.20E-4 25 2.16E-4
14 SGTC_1336 1486-0901 3.42 104.0 µM 3.21E-4 35 3.17E-4
15 SGTC_2806 7952793 3.38 58.4 µM 3.72E-4 44 3.68E-4
16 SGTC_523 1934-0222 3.32 13.7 µM 4.61E-4 53 4.58E-4
17 SGTC_1040 k898-0338 3.30 155.0 µM 4.89E-4 40 4.85E-4
18 SGTC_526 4469-0568 3.14 170.0 µM 8.50E-4 azole & statin 63 8.50E-4
19 SGTC_2796 7949634 3.13 45.5 µM 8.69E-4 60 8.69E-4
20 SGTC_1632 st005650 3.13 90.0 µM 8.89E-4 63 8.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 2.01E-29 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.184 6.10E-27 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.179 2.17E-25 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.176 1.39E-24 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.169 5.68E-23 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.167 1.76E-22 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.167 2.62E-22 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.163 2.49E-21 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.157 6.08E-20 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.155 2.41E-19 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.150 2.30E-18 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.149 3.45E-18 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.148 5.75E-18 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.148 8.33E-18 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.143 7.31E-17 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C