YKR098C / UBP11

Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR098C / UBP11

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.17|P-value:7.57E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.94|P-value:3.98E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.57|P-value:1.76E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.26|P-value:5.56E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.02|P-value:2.91E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.63|P-value:1.38E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.53|P-value:2.95E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.99|P-value:3.06E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.48|P-value:3.48E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.27|P-value:5.22E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.34|P-value:4.19E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.34|P-value:4.24E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.13|P-value:8.65E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.55|P-value:1.92E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-4.48|P-value:3.58E-6 ID:SGTC_1704|Compound:st028805|FD-Score:3.87|P-value:5.38E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.72|P-value:9.77E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.43|P-value:2.97E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.39|P-value:3.39E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.24|P-value:5.89E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.75|P-value:8.85E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.87|P-value:5.36E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.58|P-value:2.26E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.50|P-value:3.30E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.23|P-value:6.12E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.42|P-value:3.11E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.27|P-value:5.30E-4 ID:SGTC_2585|Compound:alliin|FD-Score:5.98|P-value:1.11E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.06|P-value:2.13E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.81|P-value:6.94E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.39|P-value:3.55E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.07|P-value:2.34E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.20|P-value:7.00E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.33|P-value:4.23E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:2.74E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.47|P-value:2.53E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.17|P-value:7.57E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.94|P-value:3.98E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.57|P-value:1.76E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.26|P-value:5.56E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.02|P-value:2.91E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.63|P-value:1.38E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.53|P-value:2.95E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.99|P-value:3.06E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.48|P-value:3.48E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:3.75|P-value:8.90E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.27|P-value:5.22E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.34|P-value:4.19E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.32|P-value:4.50E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.34|P-value:4.24E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.13|P-value:8.65E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.55|P-value:1.92E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-4.48|P-value:3.58E-6 ID:SGTC_1704|Compound:st028805|FD-Score:3.87|P-value:5.38E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.72|P-value:9.77E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.43|P-value:2.97E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-3.39|P-value:3.39E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.24|P-value:5.89E-4 ID:SGTC_1979|Compound:st071809|FD-Score:3.75|P-value:8.85E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.87|P-value:5.36E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.64|P-value:1.38E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.58|P-value:2.26E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.50|P-value:3.30E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.23|P-value:6.12E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.42|P-value:3.11E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.48|P-value:2.45E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.27|P-value:5.30E-4 ID:SGTC_2585|Compound:alliin|FD-Score:5.98|P-value:1.11E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.06|P-value:2.13E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.81|P-value:6.94E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.39|P-value:3.55E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.07|P-value:2.34E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.20|P-value:7.00E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.33|P-value:4.23E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:2.74E-4

Top fitness defect scores for YKR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2585 alliin 5.98 100.0 µM 1.11E-9 5 1.14E-9
2 SGTC_2611 pyromycin 5.06 23.9 µM 2.13E-7 9 2.15E-7
3 SGTC_827 3253-0474 4.99 693.0 µM 3.06E-7 6 3.09E-7
4 SGTC_772 k072-0172 4.53 35.3 µM 2.95E-6 9 2.97E-6
5 SGTC_2410 aloe-emodin-8-o-glycoside 4.50 46.3 µM 3.30E-6 mitochondrial processes 14 3.32E-6
6 SGTC_2834 9001755 4.07 58.4 µM 2.34E-5 32 2.35E-5
7 SGTC_637 1181-0519 4.02 7.3 µM 2.91E-5 fatty acid desaturase (OLE1) 98 2.92E-5
8 SGTC_296 1222-0039 3.94 74.9 µM 3.98E-5 12 3.99E-5
9 SGTC_1991 st073000 3.87 8.9 µM 5.36E-5 NEO1 82 5.37E-5
10 SGTC_1704 st028805 3.87 70.8 µM 5.38E-5 11 5.39E-5
11 SGTC_2682 pyrogallin 3.81 40.0 µM 6.94E-5 copper-dependent oxidative stress 30 6.95E-5
12 SGTC_1979 st071809 3.75 45.3 µM 8.85E-5 RPP1 & pyrimidine depletion 17 8.86E-5
13 SGTC_911 3456-4043 3.75 236.0 µM 8.90E-5 mitochondrial processes 33 8.91E-5
14 SGTC_2137 5261020 3.64 140.0 µM 1.38E-4 51 1.38E-4
15 SGTC_2384 9036245 3.60 200.0 µM 1.62E-4 39 1.62E-4
16 SGTC_305 1682-2595 3.57 20.8 µM 1.76E-4 RNA processing & uracil transport 33 1.76E-4
17 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.55 19.1 µM 1.92E-4 33 1.92E-4
18 SGTC_2508 celastrol 3.55 40.5 µM 1.95E-4 PDR1 28 1.95E-4
19 SGTC_3334 9142812 3.46 21.9 µM 2.74E-4 43 2.74E-4
20 SGTC_1932 st074806 3.43 40.9 µM 2.97E-4 45 2.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.28E-9 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.089 2.50E-7 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 7.91E-7 YPR030W CSR2 hom Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication
0.082 1.89E-6 YDL014W NOP1 het Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
0.078 5.57E-6 YER085C_p YER085C_p hom Putative protein of unknown function
0.077 8.14E-6 YKR051W_p YKR051W_p hom Putative protein of unknown function
0.073 2.03E-5 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.073 2.44E-5 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.073 2.60E-5 YML066C SMA2 hom Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
0.073 2.61E-5 YKR076W ECM4 hom Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.070 4.36E-5 YKL089W MIF2 het Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
0.070 4.63E-5 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.070 5.34E-5 YHL037C_d YHL037C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 5.53E-5 YLR059C REX2 hom 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
0.069 6.05E-5 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport