YKR099W / BAS1

Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR099W / BAS1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.25|P-value:1.28E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-7.07|P-value:1.29E-12 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.97|P-value:4.23E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.22|P-value:7.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.18|P-value:8.60E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.75|P-value:1.02E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.46|P-value:3.01E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.62|P-value:1.65E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.31|P-value:5.20E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.64|P-value:1.65E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-5.55|P-value:1.93E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.48|P-value:3.05E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.13|P-value:9.63E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-10.10|P-value:6.39E-24 ID:SGTC_1213|Compound:1315-0166|FD-Score:-10.70|P-value:1.21E-26 ID:SGTC_1214|Compound:0358-0031|FD-Score:-12.80|P-value:5.37E-37 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.37|P-value:4.40E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.79|P-value:1.15E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-5.90|P-value:2.69E-9 ID:SGTC_1857|Compound:st056007|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.45|P-value:3.35E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.19|P-value:8.18E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.36|P-value:6.28E-8 ID:SGTC_2052|Compound:5265182|FD-Score:6.18|P-value:5.20E-10 ID:SGTC_2284|Compound:7945075|FD-Score:3.33|P-value:5.12E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.13|P-value:2.30E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_2386|Compound:9075165|FD-Score:4.37|P-value:8.02E-6 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:8.87E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.80|P-value:1.09E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.15|P-value:9.47E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.86|P-value:7.15E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.40|P-value:4.00E-4 ID:SGTC_2693|Compound:st077581|FD-Score:7.17|P-value:7.47E-13 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.21|P-value:7.85E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.49|P-value:2.88E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.98|P-value:4.39E-5 ID:SGTC_3067|Compound:9117431|FD-Score:-3.79|P-value:8.86E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.92|P-value:5.41E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.67|P-value:1.50E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.25|P-value:1.28E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-7.07|P-value:1.29E-12 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.97|P-value:4.23E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.22|P-value:7.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.18|P-value:8.60E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:-3.75|P-value:1.02E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.46|P-value:3.01E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.62|P-value:1.65E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.31|P-value:5.20E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.64|P-value:1.65E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-5.55|P-value:1.93E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.48|P-value:3.05E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.13|P-value:9.63E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-10.10|P-value:6.39E-24 ID:SGTC_1213|Compound:1315-0166|FD-Score:-10.70|P-value:1.21E-26 ID:SGTC_1214|Compound:0358-0031|FD-Score:-12.80|P-value:5.37E-37 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.16|P-value:9.30E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.37|P-value:4.40E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.60|P-value:1.94E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.79|P-value:1.15E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-5.90|P-value:2.69E-9 ID:SGTC_1857|Compound:st056007|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.45|P-value:3.35E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.19|P-value:8.18E-4 ID:SGTC_2050|Compound:5263056|FD-Score:5.36|P-value:6.28E-8 ID:SGTC_2052|Compound:5265182|FD-Score:6.18|P-value:5.20E-10 ID:SGTC_2284|Compound:7945075|FD-Score:3.33|P-value:5.12E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.74|P-value:1.12E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.13|P-value:2.30E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_2386|Compound:9075165|FD-Score:4.37|P-value:8.02E-6 ID:SGTC_2404|Compound:5161160|FD-Score:3.17|P-value:8.87E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.80|P-value:1.09E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.15|P-value:9.47E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.86|P-value:7.15E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.40|P-value:4.00E-4 ID:SGTC_2693|Compound:st077581|FD-Score:7.17|P-value:7.47E-13 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.21|P-value:7.85E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.49|P-value:2.88E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.98|P-value:4.39E-5 ID:SGTC_3067|Compound:9117431|FD-Score:-3.79|P-value:8.86E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.92|P-value:5.41E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.67|P-value:1.50E-4

Top fitness defect scores for YKR099W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2693 st077581 7.17 40.7 µM 7.47E-13 3 3.85E-13
2 SGTC_2052 5265182 6.18 7.1 µM 5.20E-10 2 3.14E-10
3 SGTC_2050 5263056 5.36 171.0 µM 6.28E-8 fatty acid desaturase (OLE1) 18 4.27E-8
4 SGTC_2419 paclitaxel 4.80 166.5 µM 1.09E-6 18 7.97E-7
5 SGTC_1727 st034309 4.79 9.9 µM 1.15E-6 17 8.41E-7
6 SGTC_2386 9075165 4.37 157.4 µM 8.02E-6 5 6.13E-6
7 SGTC_2338 7999974 4.13 200.0 µM 2.30E-5 18 1.80E-5
8 SGTC_2978 9011784 3.98 43.0 µM 4.39E-5 28 3.50E-5
9 SGTC_3191 9110352 3.92 49.5 µM 5.41E-5 10 4.34E-5
10 SGTC_2634 4'-methoxyflavone 3.86 100.0 µM 7.15E-5 37 5.77E-5
11 SGTC_2372 9071633 3.76 200.0 µM 1.05E-4 14 8.54E-5
12 SGTC_2305 7443522 3.74 69.2 µM 1.12E-4 19 9.10E-5
13 SGTC_2537 larixol 3.68 68.9 µM 1.40E-4 29 1.15E-4
14 SGTC_3251 9135047 3.67 49.5 µM 1.50E-4 60S ribosome export 9 1.23E-4
15 SGTC_762 1165-0429 3.64 115.0 µM 1.65E-4 TSC3-RPN4 27 1.36E-4
16 SGTC_1695 st026914 3.60 34.5 µM 1.94E-4 28 1.61E-4
17 SGTC_2876 9059903 3.49 26.0 µM 2.88E-4 22 2.41E-4
18 SGTC_1015 4130-4525 3.48 82.0 µM 3.05E-4 60S ribosome export 38 2.55E-4
19 SGTC_1906 st060206 3.45 94.7 µM 3.35E-4 33 2.81E-4
20 SGTC_2692 st077426 3.40 47.7 µM 4.00E-4 35 3.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.399 1.47E-124 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.299 4.64E-68 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.213 1.84E-34 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.159 9.75E-20 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.146 6.08E-17 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.127 3.39E-13 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.122 2.80E-12 YAR028W_p YAR028W_p hom Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.121 4.93E-12 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.116 3.46E-11 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.103 3.41E-9 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.103 3.55E-9 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.102 5.37E-9 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
0.100 1.31E-8 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.095 6.50E-8 YGR120C COG2 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.094 7.65E-8 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division