YKR103W / NFT1

Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR103W / NFT1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:5.03|P-value:1.51E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.38|P-value:2.94E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.05|P-value:1.87E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.67|P-value:7.80E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.85|P-value:4.44E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.63|P-value:9.13E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.37|P-value:2.55E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.29|P-value:6.39E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.82|P-value:5.16E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.03|P-value:1.67E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.93|P-value:3.18E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:5.67|P-value:3.65E-9 ID:SGTC_766|Compound:1391-0721|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.28|P-value:4.34E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.94|P-value:2.97E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.55|P-value:1.51E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_1721|Compound:st082152|FD-Score:6.51|P-value:1.57E-11 ID:SGTC_1790|Compound:st045711|FD-Score:3.32|P-value:3.68E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.89|P-value:9.71E-10 ID:SGTC_2092|Compound:5303694|FD-Score:4.77|P-value:5.97E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.14|P-value:1.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.83|P-value:4.87E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.09|P-value:8.36E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.50|P-value:1.84E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.32|P-value:3.70E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.67|P-value:3.78E-9 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.92|P-value:2.74E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.63|P-value:9.18E-5 ID:SGTC_2845|Compound:9003024|FD-Score:4.01|P-value:2.19E-5 ID:SGTC_2846|Compound:9008642|FD-Score:6.09|P-value:2.55E-10 ID:SGTC_2919|Compound:7978188|FD-Score:5.97|P-value:5.64E-10 ID:SGTC_3007|Compound:9078383|FD-Score:-3.05|P-value:8.46E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.38|P-value:2.96E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.04|P-value:9.98E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.04|P-value:8.51E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.04|P-value:1.41E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-3.01|P-value:9.53E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.26|P-value:3.91E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.67|P-value:9.47E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-4.10|P-value:1.21E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:5.03|P-value:1.51E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.38|P-value:2.94E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.05|P-value:1.87E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.67|P-value:7.80E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.85|P-value:4.44E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.63|P-value:9.13E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.37|P-value:2.55E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.29|P-value:6.39E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.82|P-value:5.16E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.03|P-value:1.67E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.93|P-value:3.18E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:5.67|P-value:3.65E-9 ID:SGTC_766|Compound:1391-0721|FD-Score:3.30|P-value:3.90E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.49|P-value:1.89E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.28|P-value:4.34E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.41|P-value:2.61E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.94|P-value:2.97E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.30|P-value:3.92E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.55|P-value:1.51E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_1721|Compound:st082152|FD-Score:6.51|P-value:1.57E-11 ID:SGTC_1790|Compound:st045711|FD-Score:3.32|P-value:3.68E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.12|P-value:7.53E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.89|P-value:9.71E-10 ID:SGTC_2092|Compound:5303694|FD-Score:4.77|P-value:5.97E-7 ID:SGTC_2154|Compound:5570129|FD-Score:4.14|P-value:1.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.83|P-value:4.87E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.09|P-value:8.36E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.50|P-value:1.84E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.32|P-value:3.70E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:5.67|P-value:3.78E-9 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.92|P-value:2.74E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.63|P-value:9.18E-5 ID:SGTC_2845|Compound:9003024|FD-Score:4.01|P-value:2.19E-5 ID:SGTC_2846|Compound:9008642|FD-Score:6.09|P-value:2.55E-10 ID:SGTC_2919|Compound:7978188|FD-Score:5.97|P-value:5.64E-10 ID:SGTC_3007|Compound:9078383|FD-Score:-3.05|P-value:8.46E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.38|P-value:2.96E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.04|P-value:9.98E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.04|P-value:8.51E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.04|P-value:1.41E-7 ID:SGTC_3087|Compound:9117406|FD-Score:-3.01|P-value:9.53E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.26|P-value:3.91E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.67|P-value:9.47E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_3189|Compound:9110682|FD-Score:-4.10|P-value:1.21E-5

Top fitness defect scores for YKR103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1721 st082152 6.51 9.3 µM 1.57E-11 60S ribosome export 5 3.79E-11
2 SGTC_2846 9008642 6.09 19.5 µM 2.55E-10 3 5.49E-10
3 SGTC_2919 7978188 5.97 46.4 µM 5.64E-10 2 1.17E-9
4 SGTC_2017 5132927 5.89 60.6 µM 9.71E-10 5 1.98E-9
5 SGTC_601 0986-0029 5.67 62.9 µM 3.65E-9 calcium & mitochondrial duress 11 7.03E-9
6 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 5.67 100.0 µM 3.78E-9 7 7.26E-9
7 SGTC_3027 9089541 5.04 49.5 µM 1.41E-7 fatty acid desaturase (OLE1) 5 2.34E-7
8 SGTC_100 0086-0128 5.03 49.6 µM 1.51E-7 copper-dependent oxidative stress 22 2.51E-7
9 SGTC_2092 5303694 4.77 80.7 µM 5.97E-7 TSC3-RPN4 16 9.36E-7
10 SGTC_208 k072-0098 4.29 12.4 µM 6.39E-6 heme biosynthesis & mitochondrial translocase 34 9.13E-6
11 SGTC_2154 5570129 4.14 200.0 µM 1.22E-5 12 1.70E-5
12 SGTC_171 k064-0041 4.05 9.7 µM 1.87E-5 heme requiring 26 2.56E-5
13 SGTC_2845 9003024 4.01 43.0 µM 2.19E-5 amide catabolism 43 2.98E-5
14 SGTC_1348 1493-0373 3.94 93.8 µM 2.97E-5 13 4.00E-5
15 SGTC_600 1495-0418 3.93 41.6 µM 3.18E-5 RPP1 & pyrimidine depletion 10 4.27E-5
16 SGTC_179 1273-0063 3.85 6.8 µM 4.44E-5 24 5.88E-5
17 SGTC_2250 alverine citrate 3.83 130.0 µM 4.87E-5 166 6.43E-5
18 SGTC_355 1311-2252 3.82 105.0 µM 5.16E-5 25 6.80E-5
19 SGTC_3146 9095609 3.67 49.5 µM 9.47E-5 22 1.22E-4
20 SGTC_1511 0906-3109 3.55 28.5 µM 1.51E-4 excess fatty acid 69 1.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.02E-10 YIL136W OM45 hom Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress
0.099 1.02E-8 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.090 1.74E-7 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.088 3.80E-7 YNR064C YNR064C hom Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
0.085 8.32E-7 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.083 1.56E-6 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.082 1.95E-6 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.082 2.07E-6 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.080 3.68E-6 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.079 5.06E-6 YHL041W_d YHL041W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.078 5.91E-6 YHR171W ATG7 hom Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
0.076 9.19E-6 YGL213C SKI8 hom Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype
0.075 1.38E-5 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.074 1.68E-5 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.074 1.86E-5 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication