YKR104W

Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR104W / YKR104W

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.39|P-value:3.75E-8 ID:SGTC_324|Compound:1315-0088|FD-Score:4.51|P-value:3.36E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:5.08|P-value:1.99E-7 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.48|P-value:2.54E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.39|P-value:3.47E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.20|P-value:7.86E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.16|P-value:7.95E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-5.97|P-value:1.60E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:4.55|P-value:2.76E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:3.58|P-value:1.74E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.40|P-value:3.90E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.45|P-value:4.53E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.21|P-value:7.53E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.65|P-value:1.32E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.17|P-value:1.24E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-5.99|P-value:1.46E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-5.01|P-value:3.40E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.54|P-value:1.98E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.75|P-value:9.07E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.12|P-value:1.62E-7 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.04|P-value:2.78E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.39|P-value:3.99E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.30|P-value:8.91E-6 ID:SGTC_1607|Compound:st000305|FD-Score:4.35|P-value:7.15E-6 ID:SGTC_1608|Compound:st001473|FD-Score:6.46|P-value:5.78E-11 ID:SGTC_1673|Compound:st016611|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.29|P-value:5.70E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.79|P-value:7.65E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.82|P-value:6.70E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.44|P-value:4.61E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-3.45|P-value:3.27E-4 ID:SGTC_2188|Compound:6126565|FD-Score:5.02|P-value:2.75E-7 ID:SGTC_2216|Compound:7189485|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.35|P-value:4.07E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.92|P-value:5.19E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.48|P-value:2.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.71|P-value:1.21E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.51|P-value:3.38E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.30|P-value:4.90E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.64|P-value:1.59E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.72|P-value:1.02E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:5.39|P-value:3.75E-8 ID:SGTC_324|Compound:1315-0088|FD-Score:4.51|P-value:3.36E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:5.08|P-value:1.99E-7 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.48|P-value:2.54E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.30|P-value:4.89E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.39|P-value:3.47E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.20|P-value:7.86E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.16|P-value:7.95E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-5.97|P-value:1.60E-9 ID:SGTC_778|Compound:3456-2434|FD-Score:4.55|P-value:2.76E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:3.58|P-value:1.74E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.40|P-value:3.90E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.45|P-value:4.53E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.21|P-value:7.53E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.65|P-value:1.32E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.17|P-value:1.24E-7 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-5.99|P-value:1.46E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-5.01|P-value:3.40E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.54|P-value:1.98E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.75|P-value:9.07E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.12|P-value:1.62E-7 ID:SGTC_1397|Compound:3532-0190|FD-Score:4.04|P-value:2.78E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.39|P-value:3.99E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.30|P-value:8.91E-6 ID:SGTC_1607|Compound:st000305|FD-Score:4.35|P-value:7.15E-6 ID:SGTC_1608|Compound:st001473|FD-Score:6.46|P-value:5.78E-11 ID:SGTC_1673|Compound:st016611|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.29|P-value:5.70E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.79|P-value:7.65E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.82|P-value:6.70E-5 ID:SGTC_1940|Compound:st075990|FD-Score:4.44|P-value:4.61E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-3.45|P-value:3.27E-4 ID:SGTC_2188|Compound:6126565|FD-Score:5.02|P-value:2.75E-7 ID:SGTC_2216|Compound:7189485|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.35|P-value:4.07E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.92|P-value:5.19E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.48|P-value:2.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.71|P-value:1.21E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.51|P-value:3.38E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.41|P-value:3.21E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.30|P-value:4.90E-4 ID:SGTC_3023|Compound:9089636|FD-Score:3.52|P-value:2.15E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.69|P-value:1.14E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.64|P-value:1.59E-4

Top fitness defect scores for YKR104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1608 st001473 6.46 40.5 µM 5.78E-11 12 5.12E-11
2 SGTC_322 k048-0136 5.39 19.3 µM 3.75E-8 RSC & ERG11 4 3.50E-8
3 SGTC_1155 4088-0394 5.17 48.2 µM 1.24E-7 3 1.17E-7
4 SGTC_1394 3474-0001 5.12 65.7 µM 1.62E-7 endomembrane recycling 20 1.53E-7
5 SGTC_598 3937-0236 5.08 20.2 µM 1.99E-7 ERG2 13 1.88E-7
6 SGTC_2188 6126565 5.02 140.7 µM 2.75E-7 mitochondrial processes 4 2.60E-7
7 SGTC_778 3456-2434 4.55 196.0 µM 2.76E-6 mitochondrial response to ROS 56 2.66E-6
8 SGTC_324 1315-0088 4.51 19.6 µM 3.36E-6 RSC & ERG11 5 3.25E-6
9 SGTC_2821 7996764 4.51 71.4 µM 3.38E-6 23 3.26E-6
10 SGTC_931 2812-0076 4.45 566.0 µM 4.53E-6 13 4.39E-6
11 SGTC_1940 st075990 4.44 51.1 µM 4.61E-6 60S ribosome export 11 4.46E-6
12 SGTC_1607 st000305 4.35 50.6 µM 7.15E-6 7 6.94E-6
13 SGTC_1554 st069299 4.30 38.7 µM 8.91E-6 13 8.66E-6
14 SGTC_1216 1165-0504 4.26 9.7 µM 1.03E-5 11 1.00E-5
15 SGTC_1397 3532-0190 4.04 20.1 µM 2.78E-5 6 2.72E-5
16 SGTC_1749 st037932 3.82 54.2 µM 6.70E-5 32 6.60E-5
17 SGTC_1709 st033179 3.79 39.1 µM 7.65E-5 17 7.55E-5
18 SGTC_1392 3455-1037 3.75 33.9 µM 9.07E-5 21 8.97E-5
19 SGTC_71 0417-1750 3.72 47.8 µM 1.02E-4 Golgi 53 1.01E-4
20 SGTC_3044 9093193 3.69 49.5 µM 1.14E-4 33 1.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.65E-10 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.098 1.19E-8 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.084 9.56E-7 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.083 1.64E-6 YGR080W TWF1 hom Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
0.081 2.74E-6 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.077 8.92E-6 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.075 1.27E-5 YDL075W RPL31A hom Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication
0.075 1.37E-5 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.073 2.27E-5 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.071 3.73E-5 YLL003W SFI1 het Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
0.071 3.91E-5 YDL116W NUP84 hom Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107
0.070 5.09E-5 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.068 7.49E-5 YDR074W TPS2 hom Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
0.067 9.94E-5 YIL156W UBP7 hom Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
0.066 1.35E-4 YBR037C SCO1 hom Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication