Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKR106W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.123 | 8.83E-13 | YOR282W_d | YOR282W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C |
0.119 | 4.50E-12 | YOL086W-A | MHF1 | hom | Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 |
0.117 | 1.12E-11 | YGR028W | MSP1 | hom | Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase |
0.102 | 3.00E-9 | YOL089C | HAL9 | hom | Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication |
0.102 | 3.07E-9 | YNL277W-A_p | YNL277W-A_p | hom | Putative protein of unknown function |
0.100 | 5.55E-9 | YDR239C | YDR239C | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments |
0.094 | 4.39E-8 | YNR032C-A | HUB1 | hom | Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear |
0.093 | 7.24E-8 | YBL055C | YBL055C | hom | 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases |
0.092 | 8.98E-8 | YDR160W | SSY1 | het | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
0.091 | 1.18E-7 | YHR045W_p | YHR045W_p | hom | Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum |
0.091 | 1.30E-7 | YKL138C | MRPL31 | hom | Mitochondrial ribosomal protein of the large subunit |
0.090 | 1.68E-7 | YLR307W | CDA1 | hom | Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall |
0.090 | 1.97E-7 | YNL282W | POP3 | het | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
0.088 | 3.65E-7 | YGR026W_p | YGR026W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.088 | 3.82E-7 | YDR328C | SKP1 | het | Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress |