YKR106W / GEX2

Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR106W / GEX2

Click on Significant Values for Screen Details ID:SGTC_288|Compound:1315-0019|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:5.03E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:4.70|P-value:4.59E-7 ID:SGTC_441|Compound:propafenone|FD-Score:-3.46|P-value:1.71E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-4.05|P-value:1.40E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.65|P-value:7.86E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.11|P-value:1.05E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.71|P-value:6.30E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.51|P-value:1.19E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:5.23|P-value:2.36E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:6.97|P-value:1.71E-13 ID:SGTC_623|Compound:k072-0108|FD-Score:3.10|P-value:5.77E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.27|P-value:3.06E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-4.31|P-value:4.14E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.03|P-value:8.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.58|P-value:8.63E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.03|P-value:1.51E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:-7.05|P-value:1.34E-13 ID:SGTC_1762|Compound:st045503|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.02|P-value:9.07E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.41|P-value:2.04E-6 ID:SGTC_1769|Compound:st044406|FD-Score:-3.05|P-value:8.03E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.88|P-value:3.02E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.10|P-value:5.85E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-4.35|P-value:3.34E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.48|P-value:1.36E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.99|P-value:1.52E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.65|P-value:6.75E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.77|P-value:3.97E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.08|P-value:6.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.20|P-value:2.80E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.85|P-value:2.49E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.25|P-value:3.91E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.67|P-value:6.13E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.66|P-value:6.43E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.45|P-value:6.35E-9 ID:SGTC_2783|Compound:7738165|FD-Score:-3.22|P-value:4.38E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.16|P-value:4.66E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.04|P-value:7.13E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.04|P-value:8.41E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.10|P-value:8.93E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.49|P-value:1.32E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.52|P-value:1.15E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:5.03E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:4.70|P-value:4.59E-7 ID:SGTC_441|Compound:propafenone|FD-Score:-3.46|P-value:1.71E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-4.05|P-value:1.40E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.65|P-value:7.86E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.11|P-value:1.05E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.71|P-value:6.30E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:4.51|P-value:1.19E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:5.23|P-value:2.36E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:6.97|P-value:1.71E-13 ID:SGTC_623|Compound:k072-0108|FD-Score:3.10|P-value:5.77E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.27|P-value:3.06E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-4.31|P-value:4.14E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.03|P-value:8.74E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.58|P-value:8.63E-7 ID:SGTC_769|Compound:0302-0231|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.22|P-value:4.35E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-4.03|P-value:1.51E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:-7.05|P-value:1.34E-13 ID:SGTC_1762|Compound:st045503|FD-Score:3.44|P-value:1.58E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.02|P-value:9.07E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.41|P-value:2.04E-6 ID:SGTC_1769|Compound:st044406|FD-Score:-3.05|P-value:8.03E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.88|P-value:3.02E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.41|P-value:1.78E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.10|P-value:5.85E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-4.35|P-value:3.34E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.48|P-value:1.36E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.99|P-value:1.52E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.65|P-value:6.75E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.77|P-value:3.97E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.08|P-value:6.36E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.20|P-value:2.80E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.85|P-value:2.49E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.25|P-value:3.91E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.67|P-value:6.13E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.06|P-value:7.75E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.66|P-value:6.43E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.45|P-value:6.35E-9 ID:SGTC_2783|Compound:7738165|FD-Score:-3.22|P-value:4.38E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.16|P-value:4.66E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.04|P-value:7.13E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.04|P-value:8.41E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.10|P-value:8.93E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.49|P-value:1.32E-4

Top fitness defect scores for YKR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_542 3381-0244 6.97 89.3 µM 1.71E-13 11 1.56E-12
2 SGTC_2756 carbadox 5.45 75.1 µM 6.35E-9 23 2.55E-8
3 SGTC_540 1187-0821 5.23 17.3 µM 2.36E-8 5 8.56E-8
4 SGTC_2563 tomatine 5.20 8.5 µM 2.80E-8 20 1.00E-7
5 SGTC_383 2324-0395 4.70 7.4 µM 4.59E-7 azole & statin 23 1.32E-6
6 SGTC_767 0929-0023 4.58 86.0 µM 8.63E-7 TRP & mitochondrial translation 49 2.37E-6
7 SGTC_539 4859-0462 4.51 2.5 µM 1.19E-6 RNA pol III & RNase P/MRP 10 3.19E-6
8 SGTC_1768 st044301 4.41 37.2 µM 2.04E-6 10 5.24E-6
9 SGTC_2991 9074669 4.10 71.4 µM 8.93E-6 azole & statin 57 2.05E-5
10 SGTC_1977 st070720 3.99 65.3 µM 1.52E-5 8 3.35E-5
11 SGTC_2405 ticlatone 3.77 3.5 µM 3.97E-5 71 8.11E-5
12 SGTC_535 2293-4129 3.74 48.2 µM 4.65E-5 NEO1 71 9.38E-5
13 SGTC_310 1273-0058 3.72 1.1 µM 5.03E-5 mitochondrial stress 259 1.01E-4
14 SGTC_2598 perillyl alcohol 3.67 100.0 µM 6.13E-5 43 1.21E-4
15 SGTC_2752 diclazuril 3.66 33.1 µM 6.43E-5 141 1.27E-4
16 SGTC_2119 5528445 3.65 120.6 µM 6.75E-5 32 1.32E-4
17 SGTC_288 1315-0019 3.52 35.1 µM 1.15E-4 RSC & ERG11 32 2.16E-4
18 SGTC_769 0302-0231 3.51 76.0 µM 1.18E-4 65 2.22E-4
19 SGTC_3342 9147791 3.49 14.5 µM 1.32E-4 33 2.46E-4
20 SGTC_1976 st070609 3.48 63.5 µM 1.36E-4 23 2.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.83E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.119 4.50E-12 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.117 1.12E-11 YGR028W MSP1 hom Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.102 3.00E-9 YOL089C HAL9 hom Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication
0.102 3.07E-9 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.100 5.55E-9 YDR239C YDR239C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.094 4.39E-8 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.093 7.24E-8 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.092 8.98E-8 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.091 1.18E-7 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.091 1.30E-7 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.090 1.68E-7 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.090 1.97E-7 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.088 3.65E-7 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.088 3.82E-7 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress