YLL001W / DNM1

Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL001W / DNM1

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:4.22|P-value:2.93E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:13.20|P-value:2.73E-46 ID:SGTC_116|Compound:0155-0182|FD-Score:3.48|P-value:9.13E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.50|P-value:8.58E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.01|P-value:6.08E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.54|P-value:1.30E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.94|P-value:7.78E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.00|P-value:6.05E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.02|P-value:5.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.55|P-value:6.86E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.34|P-value:1.64E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.17|P-value:3.70E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.29|P-value:1.99E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.00|P-value:6.04E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.02|P-value:5.94E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:6.77|P-value:1.64E-13 ID:SGTC_769|Compound:0302-0231|FD-Score:2.96|P-value:7.30E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:7.63|P-value:1.17E-16 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.01|P-value:7.98E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:2.89|P-value:9.59E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.20|P-value:2.97E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.47|P-value:9.47E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.93|P-value:4.66E-14 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.53|P-value:7.23E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.35|P-value:1.50E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.20|P-value:2.83E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.52|P-value:7.60E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.20|P-value:2.93E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.67|P-value:2.65E-7 ID:SGTC_1620|Compound:st003704|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.31|P-value:1.89E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:4.43E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.56|P-value:6.40E-5 ID:SGTC_1866|Compound:st057638|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.12|P-value:4.55E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.95|P-value:7.67E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:1.26E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.59|P-value:5.83E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.04|P-value:5.22E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.97|P-value:6.76E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-4.82|P-value:1.05E-7 ID:SGTC_3251|Compound:9135047|FD-Score:3.00|P-value:6.28E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.22|P-value:2.93E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:13.20|P-value:2.73E-46 ID:SGTC_116|Compound:0155-0182|FD-Score:3.48|P-value:9.13E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.50|P-value:8.58E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.01|P-value:6.08E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:5.54|P-value:1.30E-9 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.25|P-value:2.42E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.94|P-value:7.78E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.00|P-value:6.05E-4 ID:SGTC_482|Compound:fipronil|FD-Score:3.02|P-value:5.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.55|P-value:6.86E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.34|P-value:1.64E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.17|P-value:3.70E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.29|P-value:1.99E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.00|P-value:6.04E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.02|P-value:5.94E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:6.77|P-value:1.64E-13 ID:SGTC_769|Compound:0302-0231|FD-Score:2.96|P-value:7.30E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:7.63|P-value:1.17E-16 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.01|P-value:7.98E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:2.89|P-value:9.59E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.20|P-value:2.97E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.47|P-value:9.47E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.93|P-value:4.66E-14 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.53|P-value:7.23E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.17|P-value:3.32E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.35|P-value:1.50E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.20|P-value:2.83E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.52|P-value:7.60E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.20|P-value:2.93E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.67|P-value:2.65E-7 ID:SGTC_1620|Compound:st003704|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.31|P-value:1.89E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:4.43E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.56|P-value:6.40E-5 ID:SGTC_1866|Compound:st057638|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.12|P-value:4.55E-6 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.95|P-value:7.67E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:1.26E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.59|P-value:5.83E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.04|P-value:5.22E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.97|P-value:6.76E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-4.82|P-value:1.05E-7 ID:SGTC_3251|Compound:9135047|FD-Score:3.00|P-value:6.28E-4

Top fitness defect scores for YLL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_115 0527-0192 13.20 112.0 µM 2.73E-46 2 2.74E-40
2 SGTC_795 0685-0265 7.63 78.0 µM 1.17E-16 excess fatty acid 4 1.19E-14
3 SGTC_922 1866-0035 6.93 480.0 µM 4.66E-14 excess fatty acid 12 2.13E-12
4 SGTC_743 1275-0778 6.77 158.0 µM 1.64E-13 excess fatty acid 8 6.35E-12
5 SGTC_306 1672-3436 5.54 11.6 µM 1.30E-9 Golgi 3 1.52E-8
6 SGTC_1613 st002381 4.67 52.1 µM 2.65E-7 11 1.54E-6
7 SGTC_1351 1496-0003 4.35 46.5 µM 1.50E-6 14 6.95E-6
8 SGTC_114 0364-0001 4.22 490.3 µM 2.93E-6 45 1.25E-5
9 SGTC_529 4076-0302 4.17 30.3 µM 3.70E-6 mitochondrial processes 17 1.53E-5
10 SGTC_2682 pyrogallin 3.59 40.0 µM 5.83E-5 copper-dependent oxidative stress 36 1.68E-4
11 SGTC_1841 st054148 3.56 70.0 µM 6.40E-5 17 1.83E-4
12 SGTC_513 4245-1575 3.55 41.7 µM 6.86E-5 unfolded protein response 137 1.94E-4
13 SGTC_1544 7-methoxy-4-methylcoumarin 3.52 105.0 µM 7.60E-5 28 2.12E-4
14 SGTC_178 4092-0806 3.50 87.5 µM 8.58E-5 ergosterol depletion effects on membrane 120 2.36E-4
15 SGTC_116 0155-0182 3.48 31.8 µM 9.13E-5 mitochondrial response to ROS 117 2.49E-4
16 SGTC_1620 st003704 3.44 16.5 µM 1.09E-4 31 2.90E-4
17 SGTC_1692 fluoroquinolonic acid 3.44 71.0 µM 1.09E-4 15 2.90E-4
18 SGTC_1371 2421-0008 3.44 32.7 µM 1.11E-4 mitochondrial processes 64 2.95E-4
19 SGTC_2541 muurolladie-3-one 3.41 83.1 µM 1.26E-4 excess fatty acid 52 3.31E-4
20 SGTC_523 1934-0222 3.34 13.7 µM 1.64E-4 48 4.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.339 3.83E-91 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.274 5.52E-59 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.223 5.30E-39 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.203 2.05E-32 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.189 3.23E-28 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.157 5.49E-20 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.155 1.45E-19 YBR238C YBR238C hom Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.154 2.81E-19 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.150 1.88E-18 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.150 2.07E-18 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.150 2.94E-18 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.142 1.67E-16 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.126 2.96E-13 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.120 2.66E-12 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.118 8.83E-12 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard